Retinal Degeneration
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Cell Collection to Study Eye Diseases
An NEI-sponsored clinical trial update describes cell collection to study eye diseases, including age-related macular degeneration, retinal …
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Natural History of Eye Diseases Related to ABCA4 Mutations
The NEI-sponsored study investigates the natural history of ABCA4-related eye diseases, including retinal degeneration, and is currently act…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: Oral Metformin for Treatment of ABCA4 Retinopathy [Phase 1, Phase 2]
An oral metformin trial for ABCA4 retinopathy and Stargardt disease is in Phase 1/Phase 2 and currently recruiting.
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: Rod and Cone Mediated Function in Retinal Disease
Clinical trial registry entry for a study of rod and cone mediated function in retinal disease, sponsored by the National Eye Institute, cur…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: A Study to Investigate the Safety of OpCT-001 in Adults Who Have Primary Photoreceptor Disease (CLARICO) [Phase 1, Phase 2]
This clinical trial update reports that recruitment is ongoing for a Phase 1/2 study evaluating the safety of OpCT-001 in adults with primar…
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CLINICAL_TRIALS trial_result · 2026-03-31Clinical Trial Update: First-in-Human, Dose Escalation Trial of AXV-101 in BBS1-Related Retinal Degeneration [EARLY_Phase 1]
This notice reports a first-in-human, dose-escalation Phase 1 trial of AXV-101 for Bardet-Biedl syndrome type 1–related retinal degeneration…
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CLINICAL_TRIALS research · 2026-02-23Clinical Trial Update: Multicenter Study of Transcranial Magnetic Stimulation on Vision Restoration [NA]
A multicenter study evaluating transcranial magnetic stimulation for vision restoration is planned, with recruitment not yet started.
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CLINICAL_TRIALS research · 2026-02-04Clinical Trial Update: Rate of Progression of PCDH15-Related Retinal Degeneration in Usher Syndrome 1F
This update describes a clinical trial evaluating the rate of progression of PCDH15-related retinal degeneration in Usher syndrome type 1F; …
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CLINICAL_TRIALS research · 2025-12-02Clinical Trial Update: A Repeat-Dose, Open-Label, Two Arm Safety and Efficacy Study of Two Doses of VP-001 Administered Intravitreally in Participants With Confirmed PRPF31 Mutation-Associated Retinal Dystrophy, Including Participants Previously Treated With VP001 [Phase 1, Phase 2]
A two-arm, repeat-dose, open-label Phase 1/2 trial evaluating two intravitreal doses of VP-001 in participants with PRPF31 mutation-associat…
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CLINICAL_TRIALS research · 2025-11-18Clinical Trial Update: High Resolution, High-speed Multimodal Ophthalmic Imaging [NA]
This clinical trial update describes recruitment for a study of high-resolution, high-speed multimodal ophthalmic imaging technologies evalu…
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CLINICAL_TRIALS research · 2025-06-06Clinical Trial Update: Retinal Atrophy and Neurofilament Light Chain in People With Multiple Sclerosis Taking Ofatumumab
A Johns Hopkins-led clinical trial update evaluating retinal atrophy and Neurofilament Light Chain levels in people with multiple sclerosis …
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CLINICAL_TRIALS trial_result · 2025-06-06Clinical Trial Update: A Efficacy and Safety Study of Ranibizumab 10mg/ml Injection (Incepta) in Patients With Diabetic Macular Edema [Phase 3]
A Phase 3 clinical trial evaluating the efficacy and safety of ranibizumab 10 mg/mL injections for diabetic macular edema is currently recru…
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CLINICAL_TRIALS research · 2025-04-30Clinical Trial Update: Safety and Efficacy Study of IVB102 Injection in Subjects With X-linked Retinoschisis [EARLY_Phase 1]
A Phase 1 safety and efficacy study of IVB102 for X-linked retinoschisis is registered and currently active but not recruiting.
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CLINICAL_TRIALS research · 2025-04-03Clinical Trial Update: Adaptive Optics Imaging of Outer Retinal Diseases
A clinical trial update for adaptive optics imaging of outer retinal diseases, currently recruiting across multiple retinal conditions.
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CLINICAL_TRIALS trial_result · 2025-03-25Clinical Trial Update: A Long-Term Follow-Up Study in Subjects Who Received vMCO-I Administered Via Intravitreal Injection
A long-term follow-up study update of subjects who received intravitreal vMCO-I, focusing on durability and safety of the therapy over time.
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CLINICAL_TRIALS trial_result · 2024-11-26Clinical Trial Update: BCI and Evaluation of Visual and Task Performance in Subjects With Eye Diseases [NA]
A completed clinical trial update describes a brain-computer interface (BCI) study assessing visual and task performance in subjects with ey…
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CLINICAL_TRIALS trial_result · 2024-08-21Clinical Trial Update: Performance of Long-wavelength Autofluorescence Imaging [NA]
Clinical trial update on the performance of long-wavelength autofluorescence imaging in retinal diseases; the study has completed.
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CLINICAL_TRIALS trial_result · 2022-10-31Clinical Trial Update: A Multiple Dose Study of Repeat Intravitreal Injections of GEM103 in Neovascular Age-related Macular Degeneration [Phase 2]
Phase 2 trial of multiple-dose intravitreal GEM103 for neovascular age-related macular degeneration was terminated, with results posted in 2…
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CLINICAL_TRIALS trial_result · 2021-10-15Clinical Trial Update: Treatment of Cystoid Macular Edema in Patients With Retinal Degeneration [Phase 4]
This is a Phase 4 clinical trial update investigating treatment of cystoid macular edema in patients with retinal degeneration; results have…
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CLINICAL_TRIALS trial_result · 2021-06-09Clinical Trial Update: Dose-Escalation Study to Evaluate the Safety and Tolerability of Intravitreal vMCO-I in Patients With Advanced Retinitis Pigmentosa [Phase 1, Phase 2]
A dose-escalation study evaluating intravitreal vMCO-I for safety and tolerability in advanced retinitis pigmentosa has completed (Phase 1/2…
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CLINICAL_TRIALS trial_result · 2019-07-08Clinical Trial Update: Intravitreal Mesenchymal Stem Cell Transplantation in Advanced Glaucoma. [Phase 1]
A Phase 1 trial evaluating intravitreal mesenchymal stem cell transplantation for advanced glaucoma (and retinal degeneration) has completed…
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CLINICAL_TRIALS research · 2019-06-28Clinical Trial Update: Changes of Macular Pigment and Parameters of Eyes After YAG Laser Treatment in Cases With Capsule Opacification [NA]
Clinical trial update examining changes in macular pigment and ocular parameters after YAG laser treatment for capsule opacification; result…
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CLINICAL_TRIALS trial_result · 2018-04-05Clinical Trial Update: Molecular Genetics of Retinal Degenerations
Clinical trial update from the National Eye Institute on molecular genetics of retinal degenerations, including retinitis pigmentosa; the st…
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CLINICAL_TRIALS research · 2017-07-21Clinical Trial Update: Effectiveness and Safety of Adipose-Derived Regenerative Cells for Treatment of Glaucomatous Neurodegeneration [Phase 1, Phase 2]
A phase 1/2 clinical trial update evaluating adipose-derived regenerative cells for glaucomatous neurodegeneration, including retinal degene…
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CLINICAL_TRIALS trial_result · 2017-05-12Clinical Trial Update: The Effect of Laser Treatment on Macular Pigment of Eye in Cases With Diabetes [NA]
Clinical trial update on the effect of laser treatment on macular pigment in individuals with diabetes; status shows the study is completed.