Restless Legs Syndrome
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2026-04-27Clinical Trial Update: Treatment of Restless Leg Syndrome (RLS) Augmentation With Ecopipam, a D1 Specific Antagonist [Phase 1, Phase 2]
A combined Phase 1/2 trial evaluating Ecopipam, a D1-specific antagonist, for Restless Legs Syndrome with augmentation has completed with re…
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CLINICAL_TRIALS trial_result · 2026-04-27Clinical Trial Results: Treatment of Restless Leg Syndrome (RLS) Augmentation With Ecopipam, a D1 Specific Antagonist [Phase 1, Phase 2]
Clinical trial results evaluating Ecopipam, a D1 receptor antagonist, for augmentation of Restless Legs Syndrome.
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CLINICAL_TRIALS trial_result · 2026-03-13Clinical Trial Update: A Proof of Concept, Phase 2, Double-blind, Randomized Trial With d-Methadone Product Versus Placebo [Phase 2]
Phase 2 double-blind randomized trial comparing a d-Methadone product to placebo for restless legs syndrome is currently suspended.
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CLINICAL_TRIALS trial_result · 2025-12-29Clinical Trial Update: Restless Legs Syndrome in Temporomandibular Joint Disorders
A clinical trial investigating restless legs syndrome in patients with temporomandibular joint disorders has completed.
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CLINICAL_TRIALS trial_result · 2025-10-14Clinical Trial Update: Impact of Iron Supplementation Treatment on Brain Iron Concentrations
A completed clinical trial assessed whether iron supplementation affects brain iron concentrations in individuals with ADHD and iron deficie…
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CLINICAL_TRIALS trial_result · 2025-09-22Clinical Trial Update: Treatment of Restless Legs Symptoms With Pramipexole to Improve the Outcomes of Protracted Opioid Withdrawal in OUD [Phase 2, Phase 3]
A Phase 2/3 trial evaluating pramipexole for restless legs symptoms to improve outcomes during protracted opioid withdrawal in opioid use di…
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CLINICAL_TRIALS trial_result · 2025-08-17Clinical Trial Update: Restless Legs Syndrome and Sleep Quality in Pes Planus
A completed clinical trial update from Bozok University examining Restless Legs Syndrome, depression, and sleep quality in individuals with …
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CLINICAL_TRIALS trial_result · 2025-08-15Clinical Trial Update: Response to an Investigational Device in Patients With Restless Legs Syndrome [NA]
Update on a clinical trial evaluating an investigational device for Restless Legs Syndrome; the study is currently active but not recruiting…
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CLINICAL_TRIALS trial_result · 2025-07-24Clinical Trial Update: A Post-Market Study for Long-Term Effectiveness and Safety of the NTX100 for RLS
Post-market study to evaluate long-term effectiveness and safety of NTX100 in Restless Legs Syndrome; the study is currently ACTIVE_NOT_RECR…
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CLINICAL_TRIALS trial_result · 2025-07-14Clinical Trial Update: Effect of Massage Therapy on Severity of Restless Legs Syndrome and Quality of Life in Hemodialysis Patients [NA]
This study completion reports on the effects of massage therapy on the severity of restless legs syndrome and quality of life in patients un…
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CLINICAL_TRIALS trial_result · 2025-05-06Clinical Trial Update: Intravenous Iron Metabolism in Restless Legs Syndrome [Phase 2]
A Phase 2 trial evaluating intravenous iron metabolism in restless legs syndrome has completed and posted results, sponsored by American Reg…
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CLINICAL_TRIALS trial_result · 2025-02-10Clinical Trial Update: Cranial Electrotherapy for Military Beneficiaries With Restless Legs Syndrome [NA]
The clinical trial evaluating cranial electrotherapy for Restless Legs Syndrome in military beneficiaries has completed. This update does no…
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CLINICAL_TRIALS trial_result · 2024-11-08Clinical Trial Update: Post-marketing Study of Gabapentin Enacarbil to Evaluate the Effect in Restless Leg Syndrome (RLS) Patients With Moderate Renal Impairment [Phase 4]
Phase 4 post-marketing study evaluating the effect of gabapentin enacarbil in Restless Legs Syndrome patients with moderate renal impairment…
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CLINICAL_TRIALS trial_result · 2024-09-26Clinical Trial Update: Effect of Progressive Muscle Relaxation Exercises in Menopausal Women Experiencing RLS. [NA]
A completed clinical trial evaluated progressive muscle relaxation exercises for menopausal women with Restless Legs Syndrome.
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: Noninvasive Peripheral Nerve Stimulation for Restless Legs Syndrome During Opioid Medication Reduction [NA]
Completed clinical trial results for noninvasive peripheral nerve stimulation to treat Restless Legs Syndrome during opioid reduction were p…
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: Noninvasive Peripheral Nerve Stimulation for Medication-Refractory Primary RLS (The RESTFUL Study) [NA]
The RESTFUL study, sponsored by Noctrix Health, evaluated noninvasive peripheral nerve stimulation for medication-refractory primary Restles…
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: Extension Study Evaluating NTX100 Neuromodulation System for Medication-Refractory Primary RLS [NA]
Extension study evaluating the NTX100 neuromodulation system for medication-refractory primary Restless Legs Syndrome has completed, with re…
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CLINICAL_TRIALS trial_result · 2024-08-28Clinical Trial Update: Benefits of a Cannabidiolic Acid Topical Cream for the Treatment of Restless Leg Syndrome [Phase 1, Phase 2]
A Phase 1/2 clinical trial is evaluating a cannabidiolic acid topical cream for Restless Legs Syndrome; the study is currently active but no…
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CLINICAL_TRIALS trial_result · 2024-07-26Clinical Trial Update: PMR Versus MLD on RLS and Sleep Quality in Hemodialysis Patients [NA]
A completed clinical trial comparing PMR vs MLD to assess effects on restless legs syndrome symptoms and sleep quality in patients undergoin…
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CLINICAL_TRIALS trial_result · 2024-06-21Clinical Trial Update: Exercise Training Versus Ropinirole in Treating Restless Legs Syndrome Among Hemodialysis Patients [NA]
A completed clinical trial comparing exercise training to ropinirole for treating restless legs syndrome in patients undergoing hemodialysis…
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CLINICAL_TRIALS trial_result · 2024-05-22Clinical Trial Update: Oral Iron Frequency for Childhood Restless Leg Syndrome/Periodic Limb Movement Disorder [Phase 4]
Phase 4 trial evaluating different frequencies of oral iron dosing in children with Restless Legs Syndrome and Periodic Limb Movement Disord…
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CLINICAL_TRIALS trial_result · 2024-05-14Clinical Trial Update: Investigation of the Effects of Medium Cut-off Dialyzers Versus High-Flux Dialyzers on Clinical and Laboratory Parameters of Prevalent Hemodialysis Patients
This completed study compares medium cut-off dialyzers to high-flux dialyzers in prevalent hemodialysis patients. It assesses effects on cli…
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CLINICAL_TRIALS trial_result · 2024-04-25Clinical Trial Update: Study of Istradefylline (KW-6002) for the Treatment of Restless Legs Syndrome [Phase 2]
Phase 2 trial of istradefylline (KW-6002) for restless legs syndrome has completed.
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CLINICAL_TRIALS trial_result · 2024-01-16Clinical Trial Update: Efficacy of Suvorexant in Patients With Effectively Treated Restless Legs Syndrome and Persistent Chronic Insomnia [Phase 4]
Phase 4 trial evaluating suvorexant for efficacy in patients with effectively treated restless legs syndrome and persistent chronic insomnia…
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CLINICAL_TRIALS trial_result · 2023-10-30Clinical Trial Update: A Follow-up Study of Rotigotine Patch in Adolescent Subjects With Restless Legs Syndrome [Phase 3]
A Phase 3 follow-up study of rotigotine patch in adolescents with Restless Legs Syndrome was terminated; results have been posted.