Restless Legs Syndrome
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2026-04-27Clinical Trial Update: Treatment of Restless Leg Syndrome (RLS) Augmentation With Ecopipam, a D1 Specific Antagonist [Phase 1, Phase 2]
A combined Phase 1/2 trial evaluating Ecopipam, a D1-specific antagonist, for Restless Legs Syndrome with augmentation has completed with re…
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CLINICAL_TRIALS trial_result · 2026-04-27Clinical Trial Results: Treatment of Restless Leg Syndrome (RLS) Augmentation With Ecopipam, a D1 Specific Antagonist [Phase 1, Phase 2]
Clinical trial results evaluating Ecopipam, a D1 receptor antagonist, for augmentation of Restless Legs Syndrome.
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: A Self-Controlled Study on the Treatment of Restless Legs Syndrome in Uremia With Dipyridamole [Phase 2, Phase 3]
A clinical trial update announces ongoing Phase 2/Phase 3 studies evaluating dipyridamole for restless legs syndrome due to uraemia, current…
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EMA approval · 2026-04-07EMA Authorised: Neupro (rotigotine) — UCB Pharma S.A.
The EMA has authorised Neupro (rotigotine) by UCB Pharma S.A. for Restless legs syndrome and Parkinson's disease.
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CLINICAL_TRIALS trial_result · 2026-03-13Clinical Trial Update: A Proof of Concept, Phase 2, Double-blind, Randomized Trial With d-Methadone Product Versus Placebo [Phase 2]
Phase 2 double-blind randomized trial comparing a d-Methadone product to placebo for restless legs syndrome is currently suspended.
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CLINICAL_TRIALS research · 2026-03-06Clinical Trial Update: Novel Calcium Channel Modulators in RLS and Variants: Efficacy & Safety [Phase 1]
Phase 1 clinical trial evaluating investigational calcium channel modulators for efficacy and safety in restless legs syndrome (including it…
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CLINICAL_TRIALS research · 2026-03-02Clinical Trial Update: Treating Leg Symptoms in Women With X-linked Adrenoleukodystrophy [Phase 4]
Clinical trial update on a Phase 4 study evaluating treatments for leg symptoms in women with X-linked adrenoleukodystrophy, including restl…
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CLINICAL_TRIALS research · 2026-02-13Clinical Trial Update: The Suggested Immobilization Test With Exploratory Heart Rate Variability Analysis for Diagnosis of Restless Legs Syndrome [NA]
This clinical trial is recruiting to evaluate the suggested immobilization test with exploratory heart rate variability analysis for diagnos…
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FDA approval · 2026-02-12FDA Approved: GABAPENTIN — Supplemental Application (Ascend Laboratories, LLC)
FDA approved a supplemental application for gabapentin by Ascend Laboratories, LLC, updating regulatory approval for this generic product.
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CLINICAL_TRIALS research · 2026-02-09Clinical Trial Update: Tonic Motor Activation (TOMAC) Therapy in Patients With Restless Legs Syndrome and Dopaminergic Augmentation [NA]
A clinical trial update indicates that Tonic Motor Activation (TOMAC) therapy for Restless Legs Syndrome with dopaminergic augmentation is c…
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CLINICAL_TRIALS research · 2026-01-30Clinical Trial Update: The Effect of Spinal Cord Stimulators on Restless Leg Syndrome [NA]
A clinical trial is evaluating the effect of spinal cord stimulators on restless legs syndrome and is currently recruiting.
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CLINICAL_TRIALS research · 2026-01-02Clinical Trial Update: Study on the Mechanism of Gut Microbiota Mediating Restless Legs Syndrome Through Iron Metabolism
A clinical trial is investigating how gut microbiota may influence restless legs syndrome through iron metabolism, currently not recruiting.
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CLINICAL_TRIALS research · 2025-12-29Clinical Trial Update: Combined Effects of Near-Infrared Light and Vibration on Diabetic Patients With Restless Leg Syndrome [NA]
This clinical trial is investigating the combined effects of near-infrared light and vibration in diabetic patients with Restless legs syndr…
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CLINICAL_TRIALS trial_result · 2025-12-29Clinical Trial Update: Restless Legs Syndrome in Temporomandibular Joint Disorders
A clinical trial investigating restless legs syndrome in patients with temporomandibular joint disorders has completed.
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CLINICAL_TRIALS research · 2025-12-22Clinical Trial Update: Effect of Autogenic Training on Hemodialysis Patients [NA]
A Cairo University trial is evaluating autogenic training in hemodialysis patients, focusing on restless legs syndrome, fatigue, and sleep d…
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CLINICAL_TRIALS research · 2025-11-20Clinical Trial Update: Ecological Momentary Assessment in Patients With Restless Legs Syndrome [NA]
A recruiting clinical study by University Hospital, Bordeaux, evaluating ecological momentary assessment methods in patients with Restless l…
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FDA label_change · 2025-11-19FDA Approved: ROPINIROLE — Supplemental Application (Alembic Pharmaceuticals Limited)
FDA approved a supplemental application for ropinirole submitted by Alembic Pharmaceuticals Limited.
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CLINICAL_TRIALS research · 2025-11-13Clinical Trial Update: Tolerability and Efficacy of CBD Extract for RLS Treatment [Phase 2]
A Phase 2 clinical trial at University of Colorado Denver is evaluating tolerability and efficacy of a cannabidiol (CBD) extract for restles…
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CLINICAL_TRIALS research · 2025-11-12Clinical Trial Update: Peroneal Electrical Nerve Stimulation in Pregnancy for Restless Legs Syndrome [NA]
This clinical trial update indicates Rhode Island Hospital is recruiting for a study examining peroneal electrical nerve stimulation in preg…
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FDA approval · 2025-11-10FDA Approved: ROPINIROLE — Original Application (Elite Laboratories, Inc.)
FDA approved Elite Laboratories, Inc.'s original application for a generic ropinirole product. The drug is indicated for Parkinson's disease…
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CLINICAL_TRIALS trial_result · 2025-10-14Clinical Trial Update: Impact of Iron Supplementation Treatment on Brain Iron Concentrations
A completed clinical trial assessed whether iron supplementation affects brain iron concentrations in individuals with ADHD and iron deficie…
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CLINICAL_TRIALS research · 2025-10-07Clinical Trial Update: Comparative Effectiveness of Myofacial Release vs Cupping Therapy on Quality of Life in Restless Leg Syndrome With Knee O.A. [NA]
A clinical trial comparing myofascial release versus cupping therapy on quality of life in individuals with restless legs syndrome and knee …
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CLINICAL_TRIALS research · 2025-10-02Clinical Trial Update: Analysis of Sympathetic Activity in Willis-Ekbom Disease [NA]
This clinical trial update notes that a study examining sympathetic activity in Willis-Ekbom disease (Restless Legs Syndrome) is currently r…
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CLINICAL_TRIALS trial_result · 2025-09-22Clinical Trial Update: Treatment of Restless Legs Symptoms With Pramipexole to Improve the Outcomes of Protracted Opioid Withdrawal in OUD [Phase 2, Phase 3]
A Phase 2/3 trial evaluating pramipexole for restless legs symptoms to improve outcomes during protracted opioid withdrawal in opioid use di…
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CLINICAL_TRIALS other · 2025-09-18Clinical Trial Update: Effect of Exercises on Restless Leg Syndrome, Functional Capacity and Physical Self-perception Among Hemodialysis [NA]
Clinical trial update for a study examining the effects of exercise on restless legs syndrome, functional capacity, and physical self-percep…