Rectal Cancer
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-01-22Clinical Trial Update: Postoperative Outcomes of Single-stapled Anastomosis Combined With Transanal Natural Orifice Specimen Extraction
This clinical trial update describes a study evaluating a single-stapled anastomosis with transanal natural-orifice specimen extraction in r…
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CLINICAL_TRIALS research · 2026-01-22Clinical Trial Update: Leucine Plus Radiochemotherapy for Neoadjuvant Treatment of Locally Advanced Rectal Cancer [NA]
This clinical trial investigates adding leucine to radiochemotherapy as neoadjuvant treatment for locally advanced rectal cancer. Recruitmen…
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CLINICAL_TRIALS research · 2026-01-21Clinical Trial Update: Short-course Radiotherapy Followed by Sequential Chemotherapy With or Without PD-1 Monoclonal Antibody and Bevacizumab as Total Neoadjuvant Therapy in pMMR/MSS Locally Advanced Rectal Cancer （SPARK） [Phase 2]
Phase 2 SPARK trial evaluating total neoadjuvant therapy for pMMR/MSS locally advanced rectal cancer using short-course radiotherapy followe…
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CLINICAL_TRIALS research · 2026-01-20Clinical Trial Update: Development and Validation of a Post-operative Risk Of Local Recurrence Model Integrating Serology and Evalution (PROMISE) in Local Advanced Rectal Cancer Receiving Neoadjuvant Therapy: a Multicenter Study
A completed multicenter study validating PROMISE, a postoperative risk model that integrates serology and clinical evaluation to predict loc…
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CLINICAL_TRIALS research · 2026-01-20Clinical Trial Update: ctDNA-Informed Management of Early-Stage Rectal Cancer [Phase 2]
A Phase 2 clinical trial evaluating ctDNA-informed management for early-stage rectal cancer; the study is currently not yet recruiting.
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CLINICAL_TRIALS research · 2026-01-16Clinical Trial Update: A Single-center, Phase II Study on Efficacy & Safety of SCRT+CAPOX+Serplulimab+Bevacizumab for MSS Rectal Cancer [Phase 2]
This source describes a single-center Phase II study evaluating the efficacy and safety of SCRT+CAPOX+serplulimab+bevacizumab for microsatel…
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CLINICAL_TRIALS research · 2026-01-16Clinical Trial Update: Postoperative Complications After Neoadjuvant Chemoradiotherapy or Short-course Radiotherapy and Total Neoadjuvant Treatment: a Multicentric Retrospective Cohort Study
A multicenter retrospective cohort study examining postoperative complications after various neoadjuvant therapies for locally advanced rect…
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CLINICAL_TRIALS research · 2026-01-16Clinical Trial Update: Reinforced Versus Conventional Anastomosis in Laparoscopic Low Rectal Cancer Resection: A Comparative Study [NA]
A clinical trial evaluating reinforced versus conventional anastomosis in laparoscopic low rectal cancer surgery is currently enrolling by i…
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CLINICAL_TRIALS research · 2026-01-16Clinical Trial Update: Effect of Individualized Catheter Management on Early Removal After Rectal Cancer Surgery [NA]
Clinical trial investigating whether individualized catheter management can enable earlier removal after rectal cancer surgery; currently no…
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CLINICAL_TRIALS research · 2026-01-15Clinical Trial Update: Sample Collection for Ongoing Research and Product Evaluation Study
Natera reports an ongoing study update focused on sample collection for ongoing research and product evaluation; the trial is currently recr…
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CLINICAL_TRIALS research · 2026-01-15Clinical Trial Update: Non Inferiority Study of Preoperative Chemotherapy Without Pelvic Irradiation for Rectal Cancer [Phase 3]
A Phase 3 non-inferiority trial evaluating preoperative chemotherapy without pelvic irradiation for rectal cancer; currently recruiting.
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CLINICAL_TRIALS research · 2026-01-14Clinical Trial Update: SCRT Combined With Chemotherapy and Iparomlimab and Tuvonralimab in MSS or pMMR Patients With Locally Advanced Rectal Cancer [Phase 2]
A Phase 2 trial is evaluating short-course radiotherapy plus chemotherapy with Iparomlimab and Tuvonralimab for locally advanced rectal canc…
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CLINICAL_TRIALS research · 2026-01-14Clinical Trial Update: Radiation Therapy and Fluorouracil With or Without Combination Chemotherapy Followed by Surgery in Treating Patients With Stage II or Stage III Rectal Cancer [Phase 2]
A Phase 2 trial evaluating radiation therapy and fluorouracil with or without additional chemotherapy, followed by surgery, for patients wit…
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CLINICAL_TRIALS research · 2026-01-13Clinical Trial Update: A Series of Neoadjuvant Chemoradiotherapy Combined With Immunotherapy for Locally Advanced Rectal Cancer [Phase 2, Phase 3]
This entry reports ongoing Phase 2/Phase 3 clinical trials evaluating neoadjuvant chemoradiotherapy combined with immunotherapy for locally …
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CLINICAL_TRIALS research · 2026-01-13Clinical Trial Update: Selective Total Mesorectal Excision Based on Intra-Operative Frozen Section From Local Excision in Rectal Cancer Undergoing Neoadjuvant Chemoradiotherapy [NA]
A clinical trial investigates using intra-operative frozen section to guide selective total mesorectal excision after local excision in rect…
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CLINICAL_TRIALS research · 2026-01-08Clinical Trial Update: Standard Dose Versus High Dose of Radiotherapy in Rectal Preservation With Chemo-radiotherapy in Rectal Cancer Patients [Phase 3]
A Phase 3 clinical trial update comparing standard-dose versus high-dose radiotherapy with chemoradiotherapy for rectal preservation in rect…
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CLINICAL_TRIALS research · 2026-01-08Clinical Trial Update: A Study of Dostarlimab in Untreated dMMR/MSI-H Locally Advanced Rectal Cancer [Phase 2]
This clinical trial update describes a Phase 2 study of dostarlimab for untreated dMMR/MSI-H locally advanced rectal cancer, which is curren…
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CLINICAL_TRIALS research · 2026-01-08Clinical Trial Update: Curative Chemoradiation of Low Rectal Cancer
Clinical trial update indicates a curative chemoradiation approach for low rectal cancer is currently active but not recruiting, sponsored b…
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CLINICAL_TRIALS research · 2026-01-07Clinical Trial Update: Injection of IP-001 Into Thermally Ablated Hepatic Tumors in Patients With Colorectal Liver Metastases [Phase 2, Phase 3]
This document notes a Phase 2/3 clinical trial examining IP-001 injected into thermally ablated hepatic tumors in patients with colorectal l…
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CLINICAL_TRIALS research · 2026-01-06Clinical Trial Update: Study of Daily Step Count and Treatment Response in Rectal Cancer (STEP-R)
An ongoing trial (STEP-R) at Gazi University is evaluating whether daily step count, measured via a smart watch, correlates with treatment r…
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CLINICAL_TRIALS research · 2026-01-06Clinical Trial Update: Node-Sparing Short-Course Radiation Combined With Capecitabine and PD-1/CTLA-4 for MSS Early Rectal Cancer [Phase 2]
Phase 2 trial assessing node-sparing short-course radiation with capecitabine and PD-1/CTLA-4 inhibitors for microsatellite-stable early rec…
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CLINICAL_TRIALS research · 2026-01-05Clinical Trial Update: Trial of Nivolumab With FOLFOX After Chemoradiation in Rectal Cancer Patients [Phase 2]
This document notes that a Phase 2 trial investigating nivolumab with the FOLFOX regimen after chemoradiation in rectal cancer is active but…
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CLINICAL_TRIALS research · 2026-01-02Clinical Trial Update: Evaluating the Impact of GLP-1 Receptor Agonists With Total Neoadjuvant Therapy in Rectal Cancer [Phase 2]
Phase 2 clinical trial evaluating GLP-1 receptor agonists in combination with total neoadjuvant therapy for rectal cancer; the study is not …
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CLINICAL_TRIALS research · 2025-12-31Clinical Trial Update: Target-specific immunoPET Imaging of Digestive System Carcinoma [NA]
A recruiting clinical trial evaluating a target-specific immunoPET imaging agent for digestive system carcinomas across multiple digestive c…
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CLINICAL_TRIALS research · 2025-12-30Clinical Trial Update: Irinotecan Liposome Plus Capecitabine and Enronsubemab Combined With Short-course Radiotherapy for Neoadjuvant Treatment of Locally Advanced Rectal Cancer [Phase 2]
Phase 2 neoadjuvant trial combining liposomal irinotecan and capecitabine with enronsubemab plus short-course radiotherapy for locally advan…