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CLINICAL_TRIALS research · 2026-01-21

Clinical Trial Update: Short-course Radiotherapy Followed by Sequential Chemotherapy With or Without PD-1 Monoclonal Antibody and Bevacizumab as Total Neoadjuvant Therapy in pMMR/MSS Locally Advanced Rectal Cancer (SPARK) [Phase 2]

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Summary

Phase 2 SPARK trial evaluating total neoadjuvant therapy for pMMR/MSS locally advanced rectal cancer using short-course radiotherapy followed by sequential chem…

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Diseases / indications

Drugs mentioned

  • Bevacizumab (bevacizumab)
  • PD-1 monoclonal antibody

Snippet

Sponsor: Dechang Diao | Conditions: pMMR/MSS Locally Advanced Rectal Cancer | Phase 2 | Status: RECRUITING