Rectal Adenocarcinoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2025-03-12Clinical Trial Update: Short-Course Radiotherapy Combined with Intracavitary Brachytherapy Followed by Pucotenlimab, Bevacizumab, Oxaliplatin, and Trifluridine/Tipiracil (TAS-102) for Total Neoadjuvant Therapy of Microsatellite Stable (MSS) Locally Advanced Low Rectal Cancer [Phase 2]
Phase 2 trial evaluating total neoadjuvant therapy for microsatellite-stable locally advanced low rectal cancer using short-course radiother…
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CLINICAL_TRIALS research · 2025-03-03Clinical Trial Update: Dose Escalated Radiotherapy for Rectal Cancers Using MR-guided Radiotherapy [NA]
A clinical trial evaluating dose-escalated MR-guided radiotherapy for rectal adenocarcinoma, sponsored by Royal Marsden NHS Foundation Trust…
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CLINICAL_TRIALS research · 2025-02-18Clinical Trial Update: PRODIGE 90 - (FFCD 2204) Neoadjuvant Dostarlimab with Short Course Radiotherapy in a Watch-and-wait Strategy for Microsatellite Unstable or Mismatch Repair-deficient Locally Advanced Rectal Cancer Patients [Phase 3]
Phase 3 trial evaluating neoadjuvant dostarlimab with short-course radiotherapy in a watch-and-wait strategy for mismatch repair-deficient o…
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CLINICAL_TRIALS trial_result · 2025-01-21Clinical Trial Update: Evaluation of the Efficacy and Safety of Interleucin-2 Combined With PD-1 Monoclonal Antibody and CAPOX in Preoperative Neoadjuvant Therapy for Mid-low Locally Advanced Rectal Cancer - a Single-center, Single-arm, Open-label Clinical Trail [Phase 2]
Phase 2, single-arm study evaluating the safety and efficacy of combining Interleukin-2 with a PD-1 monoclonal antibody and CAPOX as neoadju…
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CLINICAL_TRIALS trial_result · 2024-12-05Clinical Trial Update: Comparison Between Tailored Surgery Versus Total Mesorectal Excision in ycT2-3N0M0 [NA]
A clinical trial comparing tailored surgery versus total mesorectal excision for ycT2-3N0M0 rectal adenocarcinoma has been terminated.
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CLINICAL_TRIALS trial_result · 2024-11-27Clinical Trial Update: M7824 in Patients With Metastatic Colorectal Cancer or With Advanced Solid Tumors With Microsatellite Instability [Phase 1, Phase 2]
Phase 1/2 clinical trial results for bintrafusp alfa (M7824) in metastatic colorectal cancer and MSI-H advanced solid tumors have been poste…
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CLINICAL_TRIALS research · 2024-11-20Clinical Trial Update: Asian Watch-and-Wait Database (AWWD)
A clinical trial update for the Asian Watch-and-Wait Database (AWWD) sponsored by Tata Memorial Centre for rectal cancer/rectal adenocarcino…
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CLINICAL_TRIALS research · 2024-10-17Clinical Trial Update: Concordance of Imaging and Pathology Diagnosis of Extranodal Tumour Deposits [NA]
Clinical trial update indicating the study on concordance of imaging and pathology diagnosis of extranodal tumour deposits in rectal adenoca…
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CLINICAL_TRIALS research · 2024-07-29Clinical Trial Update: Effect of Pelvic Rehabilitation After Low Anterior Resection for Cancer Rectum. - A Randomised Controlled Trial [NA]
A randomized controlled trial evaluating pelvic rehabilitation after low anterior resection for rectal cancer; the study is not yet recruiti…
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CLINICAL_TRIALS trial_result · 2024-05-21Clinical Trial Update: Panitumumab, Regorafenib, or TAS-102, in Treating Patients With Metastatic and/or Unresectable RAS Wild-Type Colorectal Cancer [Phase 2]
Phase 2 clinical trial update evaluating panitumumab, regorafenib, and TAS-102 in patients with metastatic and/or unresectable RAS wild-type…
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CLINICAL_TRIALS trial_result · 2024-05-01Clinical Trial Update: Talimogene Laherparepvec, Chemotherapy, and Radiation Therapy Before Surgery in Treating Patients With Locally Advanced or Metastatic Rectal Cancer [Phase 1]
Phase 1 study of talimogene laherparepvec with chemotherapy and radiation before surgery in locally advanced or metastatic rectal cancer; th…
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CLINICAL_TRIALS trial_result · 2024-01-31Clinical Trial Update: Short-course Radiation Followed by mFOLFOX-6 Plus COMPOUND 2055269 for Locally-advanced Rectal Adenocarcinoma [Phase 2]
Phase 2 clinical trial update evaluating short-course radiation followed by mFOLFOX-6 plus COMPOUND 2055269 for locally advanced rectal aden…
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CLINICAL_TRIALS trial_result · 2023-10-05Clinical Trial Update: Testing the Addition of a Radiation Sensitizing Drug, IPdR, to the Usual Chemotherapy Treatment (Capecitabine) During Radiation Therapy for Rectal Cancer [Phase 1]
Phase 1 trial evaluating the addition of IPdR, a radiation-sensitizing drug, to standard capecitabine-based chemoradiation for locally advan…
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CLINICAL_TRIALS trial_result · 2023-08-08Clinical Trial Update: Savolitinib in Treating Patients With MET Amplified Metastatic or Unresectable Colorectal Cancer [Phase 2]
Phase 2 trial investigating savolitinib for MET-amplified metastatic or unresectable colorectal cancer was terminated with results posted.
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CLINICAL_TRIALS trial_result · 2023-06-09Clinical Trial Update: Veliparib, Pembrolizumab, and Combination Chemotherapy in Treating Patient With Locally Advanced Rectal Cancer [Phase 2]
Phase 2 trial evaluating veliparib plus pembrolizumab and chemotherapy in locally advanced rectal cancer has completed and posted results in…
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CLINICAL_TRIALS trial_result · 2022-11-17Clinical Trial Update: Mechanical Bowel Preparation and Oral Antibiotics Versus Mechanical Bowel Preparation Only Prior Rectal Surgery [Phase 4]
Phase 4 clinical trial evaluating mechanical bowel preparation with oral antibiotics versus mechanical bowel preparation alone prior to rect…
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CLINICAL_TRIALS trial_result · 2021-12-01Clinical Trial Update: A Phase I Study of AZD6244 in Combination With Capecitabine and Radiotherapy in Locally Advanced Adenocarcinoma of the Rectum [Phase 1]
Phase I study evaluating AZD6244 with capecitabine and radiotherapy in non-metastatic rectal adenocarcinoma; the trial was terminated with r…
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CLINICAL_TRIALS trial_result · 2021-11-04Clinical Trial Update: Pelvic Radiotherapy With Concurrent Neoadjuvant FOLFOX for Patients With Newly Diagnosed Rectal Adenocarcinoma [Phase 2]
Phase 2 trial investigating pelvic radiotherapy with concurrent neoadjuvant FOLFOX for newly diagnosed rectal adenocarcinoma; study terminat…
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CLINICAL_TRIALS trial_result · 2020-11-09Clinical Trial Update: A Trial of Durvalumab (MEDI 4736) in Combination With Extended Neoadjuvant Regimens in Rectal Cancer [Phase 2]
Phase 2 trial investigating durvalumab in combination with extended neoadjuvant regimens for rectal cancer; status currently unknown.
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CLINICAL_TRIALS trial_result · 2020-07-07Clinical Trial Update: Nintedanib and Capecitabine in Treating Patients With Refractory Metastatic Colorectal Cancer [Phase 1, Phase 2]
Phase 1/2 study evaluating nintedanib with capecitabine in refractory metastatic colorectal cancer has completed with posted results.
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CLINICAL_TRIALS trial_result · 2019-06-13Clinical Trial Update: Avoiding Surgery in Rectal Cancer After Pre-Operative Therapy [Phase 2]
Phase 2 clinical trial exploring non-surgical management after pre-operative therapy in rectal adenocarcinoma to avoid surgery.
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CLINICAL_TRIALS trial_result · 2018-08-13Clinical Trial Update: Neo-adjuvant Chemoradiotherapy Using Infusional Gemcitabine Followed by Surgery for Locally Advanced Rectal Cancer [Phase 2]
Phase 2 trial update evaluating infusional gemcitabine chemoradiotherapy followed by surgery for locally advanced rectal cancer.
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CLINICAL_TRIALS trial_result · 2018-07-26Clinical Trial Update: Predictive Factors of Disease-free Survival After Complete Pathological Response to Neoadjuvant Radiotherapy in Rectal Adenocarcinoma
This clinical trial update analyzes factors predicting disease-free survival after complete pathological response to neoadjuvant radiotherap…
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CLINICAL_TRIALS research · 2018-05-15Clinical Trial Update: Evaluation of Rectal Tumor Margin Using Confocal Endomicroscopy and Comparison to Histopathology [NA]
A terminated clinical trial evaluating rectal tumor margin assessment with confocal endomicroscopy and comparing results to histopathology, …
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CLINICAL_TRIALS research · 2017-02-03Clinical Trial Update: Investigation of the Value of ctDNA in Diagnosis, Treatment, and Surveillance of Surgically Resectable Colorectal Cancer [Phase 3]
Phase 3 clinical trial assessing whether circulating tumor DNA can aid diagnosis, guide treatment decisions, and monitor recurrence in surgi…