Rectal Adenocarcinoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-22Clinical Trial Update: A Prospective, Multicenter, Single-Arm Phase II Exploratory Study of Serplulimab Combined With Oncolytic Virus H101, Short-Course Radiotherapy, and XELOX Chemotherapy as Total Neoadjuvant Treatment for Locally Advanced (cT1-3N0M0) Rectal Cancer [Phase 2]
Prospective Phase II single-arm study evaluating serplulimab with H101 oncolytic virus, short-course radiotherapy, and XELOX as total neoadj…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: A Clinical Study of Calderasib (MK-1084) With Targeted Therapy and Chemotherapy in People With Colorectal Cancer (MK-1084-012/KANDLELIT-012) [Phase 3]
Phase 3 clinical trial evaluating Calderasib (MK-1084) in combination with targeted therapy and chemotherapy for colorectal cancer is curren…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Trial Utilizing Metronidazole to Optimize the Microbiome of Rectal Adenocarcinoma Undergoing Neoadjuvant Therapy [Phase 2]
A Phase 2 clinical trial from MD Anderson Cancer Center is evaluating metronidazole to optimize the microbiome in rectal adenocarcinoma pati…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Young-Onset Colorectal Cancer
MD Anderson Cancer Center-sponsored trial NCT02863107 for young-onset colorectal cancer is currently active but not recruiting. The listed c…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: ExIST Study of LY2157299 (Galunisertib) in Rectal Cancer [Phase 2]
Clinical trial update for a Phase 2 study of Galunisertib (LY2157299) in rectal adenocarcinoma; the study is active but not currently recrui…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Testing Nivolumab and Ipilimumab With Short-Course Radiation in Locally Advanced Rectal Cancer [Phase 2]
Phase 2 trial evaluating nivolumab and ipilimumab with short-course radiation for locally advanced rectal cancer; the study is currently act…
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CLINICAL_TRIALS research · 2026-04-06Clinical Trial Update: Evaluation of Quality of Life and Utilities Following Surgical Treatment of Stage I-IV Rectal Cancer
A clinical trial assessing quality of life and health utility following surgical treatment for stage I through IV rectal cancer, sponsored b…
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CLINICAL_TRIALS research · 2026-04-06Clinical Trial Update: Phase 2 Single-Arm Rectal Cancer Brachytherapy for Patients With Low-Lying Residual Adenocarcinoma After Total Neoadjuvant Therapy to Improve Organ Preservation Rates [Phase 2]
Phase 2, single-arm trial evaluating rectal cancer brachytherapy for low-lying residual rectal adenocarcinoma after total neoadjuvant therap…
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CLINICAL_TRIALS trial_result · 2026-04-01Clinical Trial Update: Adaptive Radiation for Locally Advanced Rectal Adenocarcinoma [EARLY_Phase 1]
This clinical trial update notes an EARLY Phase 1 study evaluating adaptive radiation for locally advanced rectal adenocarcinoma is currentl…
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CLINICAL_TRIALS trial_result · 2026-03-30Clinical Trial Update: Short Course Radiation Therapy and Combination Chemotherapy for the Treatment of Stage II-III Rectal Cancer [Phase 1]
Phase 1 trial evaluating short-course radiation therapy in combination with chemotherapy for stage II-III rectal cancer is currently recruit…
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CLINICAL_TRIALS research · 2026-03-18Clinical Trial Update: A Study of Response to Standard Treatment Before Surgery in People With Rectal Cancer [NA]
A clinical trial is currently recruiting to assess the response to standard treatment before surgery in people with rectal cancer.
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CLINICAL_TRIALS research · 2026-03-16Clinical Trial Update: MRI-Guided Adaptive Radiation Therapy for Organ Preservation in Rectal Cancer [Phase 1]
Phase 1 clinical trial evaluating MRI-guided adaptive radiation therapy for organ preservation in rectal adenocarcinoma. Recruitment is ongo…
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CLINICAL_TRIALS research · 2026-03-16Clinical Trial Update: SCRT-NALIRIXELOX+Sintilimab as TNT for High-Risk LARC [NA]
An ongoing clinical trial evaluating a regimen of short-course radiotherapy (SCRT) followed by Nal-IRI XELOX and Sintilimab as total neoadju…
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CLINICAL_TRIALS research · 2026-03-11Clinical Trial Update: Circulating Tumor Cells in Patients With Locally Advanced Rectal Cancer
Clinical trial update on circulating tumor cells in patients with locally advanced or metastatic rectal adenocarcinoma; the study is current…
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CLINICAL_TRIALS research · 2026-03-05Clinical Trial Update: A Global, Integrated, Personalized, Stage-related, Multimodal Therapeutic Approach for Rectal Adenocarcinoma Based on Organ Sparing and Mininvasivity [NA]
This clinical trial proposes a global, integrated, personalized, stage-related multimodal therapy for non-metastatic rectal adenocarcinoma w…
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CLINICAL_TRIALS research · 2026-03-04Clinical Trial Update: A Study of Tucatinib and Trastuzumab in People With Rectal Cancer [Phase 2]
A Phase 2 clinical trial evaluating the combination of tucatinib and trastuzumab in rectal cancer patients is currently recruiting, includin…
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CLINICAL_TRIALS research · 2026-02-18Clinical Trial Update: Advanced Endoscopic Resections for Rectal Neoplasms
This clinical trial update outlines advanced endoscopic resection approaches for rectal neoplasms, and the study is currently not yet recrui…
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CLINICAL_TRIALS research · 2026-02-06Clinical Trial Update: Use of a Novel Camera to Check the Bowel After Polyp or Tumour Removal
This entry describes a clinical trial evaluating a novel camera to inspect the bowel after removal of polyps or tumors; the study status is …
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CLINICAL_TRIALS research · 2026-01-28Clinical Trial Update: INNATE: Immunotherapy During Neoadjuvant Therapy for Rectal Cancer [Phase 2]
Phase 2 INNATE trial evaluating immunotherapy during neoadjuvant therapy for locally advanced rectal cancer is currently active but not recr…
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CLINICAL_TRIALS research · 2026-01-23Clinical Trial Update: Study of Induction PD-1 Blockade in Subjects With Locally Advanced Mismatch Repair Deficient Solid Tumors [Phase 2]
Phase 2 clinical trial evaluating induction PD-1 blockade in locally advanced mismatch repair-deficient solid tumors. The study includes rec…
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CLINICAL_TRIALS trial_result · 2026-01-22Clinical Trial Update: Optimization of Adaptive Text Messages for Cancer Survivors (OATS II) [NA]
This update notes the completion of the OATS II trial evaluating adaptive text messaging for cancer survivors, with results posted on 2026-0…
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CLINICAL_TRIALS research · 2026-01-15Clinical Trial Update: Reporting of Tumour Deposits in Colorectal Cancer by Radiology and Pathology
This clinical trial entry from Imperial College London describes a study on reporting tumor deposits in rectal adenocarcinoma using radiolog…
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CLINICAL_TRIALS research · 2026-01-14Clinical Trial Update: ProLARS Trial: Prospective Longitudinal Follow-up of Low Anterior Resection Syndrome (LARS) and COREFO Score After Rectum Surgery in Patients Undergoing Upfront Surgery or Different Neo-adjuvant Treatment Regimens [NA]
Clinical trial update for the ProLARS study, a prospective longitudinal follow-up of Low Anterior Resection Syndrome and COREFO scores after…
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CLINICAL_TRIALS trial_result · 2025-12-19Clinical Trial Update: GRECCAR 8: Primary Tumor Resection in Rectal Cancer With Unresectable Metastasis [Phase 3]
Phase 3 GRECCAR 8 trial evaluating primary tumor resection in rectal cancer with unresectable metastases; the study status is completed.
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CLINICAL_TRIALS research · 2025-12-09Clinical Trial Update: Adaptive Radiation Boost for Rectal Cancer [Phase 1]
A Phase 1 clinical trial evaluating an adaptive radiation boost approach for rectal cancer. The study is currently recruiting.