Rectal Adenocarcinoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2025-12-04Clinical Trial Update: Evaluation Contact X-ray Brachytherapy for Rectal Preservation in Intermediate Substage Rectal Adenocarcinoma [Phase 3]
Phase 3 trial evaluating contact X-ray brachytherapy for rectal preservation in intermediate substage rectal adenocarcinoma.
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CLINICAL_TRIALS research · 2025-12-02Clinical Trial Update: The Efficacy and Safety of Neoadjuvant Therapy With Iparomlimab and Tuvonralimab in Locally Advanced MSI-H/dMMR Colorectal Cancer: An Prospective, Single-Arm Study (Neo-IT) [Phase 2]
Phase 2 neoadjuvant trial evaluating the immune therapies iparomlimab and tuvonralimab in locally advanced dMMR/MSI-H rectal adenocarcinoma;…
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CLINICAL_TRIALS research · 2025-12-02Clinical Trial Update: A Study of Botensilimab and Balstilimab for Rectal Adenocarcinoma [Phase 2]
Phase 2 clinical trial evaluating the combination of Botensilimab and Balstilimab for microsatellite-stable rectal cancer and locally advanc…
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CLINICAL_TRIALS research · 2025-11-21Clinical Trial Update: Clinical Study on the Safety and Relationship of Sintilimab Combined With Chemotherapy in Neoadjuvant Treatment of Locally Advanced Rectal Adenocarcinoma [Phase 2]
Phase 2 clinical study evaluating the safety of combining sintilimab with chemotherapy as neoadjuvant treatment for locally advanced rectal …
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CLINICAL_TRIALS trial_result · 2025-11-20Clinical Trial Update: Encorafenib, Cetuximab, and Nivolumab in Treating Patients With Microsatellite Stable, BRAFV600E Mutated Unresectable or Metastatic Colorectal Cancer [Phase 1, Phase 2]
A Phase 1/2 clinical trial is evaluating a triple combination of encorafenib, cetuximab, and nivolumab in patients with microsatellite-stabl…
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CLINICAL_TRIALS research · 2025-09-30Clinical Trial Update: SCRT Followed by CAPOX + Bev ± PD-1 Inhibitor for TNT in LARC [Phase 2]
A Phase 2 trial in locally advanced rectal cancer is testing total neoadjuvant therapy with short-course radiotherapy followed by CAPOX and …
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CLINICAL_TRIALS trial_result · 2025-09-30Clinical Trial Update: Simultaneous Boost in Neoadjuvant Radiotherapy for Rectal Cancer [Phase 2]
Phase 2 clinical trial investigating simultaneous boost in neoadjuvant radiotherapy for locally advanced rectal adenocarcinoma; the trial is…
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CLINICAL_TRIALS research · 2025-09-29Clinical Trial Update: Safety of a Boost (CXB or EBRT) in Combination With Neoadjuvant Chemoradiotherapy for Early Rectal Adenocarcinoma [Phase 3]
Phase 3 trial evaluating the safety of adding a boost with CXB or external beam radiotherapy to neoadjuvant chemoradiotherapy for early rect…
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CLINICAL_TRIALS research · 2025-09-25Clinical Trial Update: Establishing a ctDNA Biomarker to Improve Organ Preserving Strategies in Patients With Rectal Cancer
This clinical trial update outlines a study to establish a circulating tumor DNA biomarker to improve organ-preserving strategies in rectal …
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CLINICAL_TRIALS research · 2025-09-16Clinical Trial Update: xDRIVE in Metastatic Colorectal Cancer
The clinical trial update indicates the xDRIVE therapy for metastatic colorectal cancer is not yet recruiting.
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CLINICAL_TRIALS research · 2025-09-16Clinical Trial Update: Family Communications After Genetic Testing [NA]
A NOT_YET_RECRUITING clinical trial update from the Alliance for Clinical Trials in Oncology studying family communications after genetic te…
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CLINICAL_TRIALS research · 2025-09-15Clinical Trial Update: Involve-site Radiotherapy Combined With Chemotherapy and Immunotherapy as Neoadjuvant Treatment for Locally Advanced Rectal Cancer [Phase 2]
This update describes a Phase 2 clinical trial evaluating involve-site radiotherapy in combination with chemotherapy and immunotherapy as ne…
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CLINICAL_TRIALS research · 2025-09-02Clinical Trial Update: Nordic ORgan Preservation Pilot Approach Nonrandomised Single-Arm Trial for Non-Operative Management of Rectal Cancer [NA]
This clinical trial update describes a Nordic organ preservation pilot for rectal cancer using non-operative management. It is a nonrandomis…
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CLINICAL_TRIALS trial_result · 2025-08-12Clinical Trial Update: Study Evaluating Two Treatment Strategies for Rectal Cancer in Patients ≥75 Years Old [Phase 3]
A Phase 3 trial evaluating two treatment strategies for locally advanced rectal adenocarcinoma in patients aged 75 years or older; the study…
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CLINICAL_TRIALS research · 2025-08-08Clinical Trial Update: Study on the Efficacy and Safety of Neoadjuvant Radiotherapy Combined With Toripalimab, Liposomal Irinotecan, and Capecitabine in the Treatment of pMMR Locally Advanced Rectal Adenocarcinoma With Low Rectal Involvement [Phase 1]
Phase 1 clinical trial evaluating a neoadjuvant regimen combining radiotherapy with toripalimab, liposomal irinotecan, and capecitabine for …
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CLINICAL_TRIALS research · 2025-08-07Clinical Trial Update: ADAR1 Expression Level in Rectal Cancer
A recruiting clinical trial at Necmettin Erbakan University is investigating ADAR1 expression levels in rectal cancer.
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CLINICAL_TRIALS research · 2025-08-06Clinical Trial Update: A Study On The Prediction of Neoadjuvant Efficacy For Rectal Cancer Based On MR Cytometry Imaging and Deep-radiomics
Clinical trial evaluating whether MR cytometry imaging and deep radiomics can predict neoadjuvant treatment efficacy in rectal cancer. The s…
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CLINICAL_TRIALS research · 2025-07-18Clinical Trial Update: Papaverine in Combination With Radiation Therapy for the Treatment of Locally Advanced Rectal Cancer, DINOMITE Trial [Phase 1]
The DINOMITE Phase 1 trial is evaluating papaverine in combination with radiation therapy for locally advanced rectal cancer and is currentl…
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CLINICAL_TRIALS research · 2025-06-26Clinical Trial Update: FOLFOX, Botensilimab, and Balstilimab for the Treatment of Localized Rectal Cancer Before Surgery [Phase 2]
Phase 2 clinical trial evaluating FOLFOX with Botensilimab and Balstilimab for localized rectal cancer before surgery is currently recruitin…
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CLINICAL_TRIALS trial_result · 2025-06-08Clinical Trial Update: MoLiMoR - A Study With FOLFIRI-based First-line Therapy With or Without Intermittent Cetuximab [Phase 2]
A Phase 2 study (MoLiMoR) evaluated first-line FOLFIRI-based therapy with or without intermittent cetuximab in colon and rectal adenocarcino…
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CLINICAL_TRIALS research · 2025-05-22Clinical Trial Update: Evaluating Novel Therapies in ctDNA Positive GI Cancers [Phase 3]
Georgetown University is conducting a Phase 3 trial evaluating novel therapies for ctDNA-positive gastrointestinal cancers, currently recrui…
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CLINICAL_TRIALS trial_result · 2025-04-10Clinical Trial Update: Assessing the Additional Neoplasia Yield of Computer-aided Colonoscopy in a Screening Setting [NA]
This completed clinical trial evaluates whether computer-aided colonoscopy increases detection of neoplasia during colorectal cancer screeni…
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CLINICAL_TRIALS research · 2025-04-09Clinical Trial Update: A Phase ll Study of Neoadjuvant Short-course Radiotherapy Followed by Ivonescimab and Chemotherapy in pMMR/MSS Locally Advanced Rectal Cancer [Phase 2]
Phase II neoadjuvant radiotherapy followed by Ivonescimab and chemotherapy for locally advanced pMMR/MSS rectal adenocarcinoma; current stat…
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CLINICAL_TRIALS trial_result · 2025-03-27Clinical Trial Update: Can We Save the Rectum by Watchful Waiting or TransAnal Surgery Following (chemo)Radiotherapy Versus Total Mesorectal Excision for Early REctal Cancer? [Phase 2, Phase 3]
ClinicalTrials.gov entry for a Phase 2/3 study comparing watchful waiting or TransAnal surgery after (chemo)radiotherapy versus total mesore…
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CLINICAL_TRIALS trial_result · 2025-03-13Clinical Trial Update: Preoperative Short-course Radiation Followed by Envafolimab Plus CAPEOX for MSS Locally Advanced Rectal Adenocarcinoma (PRECAM) [Phase 2]
Phase 2 PRECAM trial evaluating preoperative short-course radiation followed by Envafolimab plus CAPEOX in microsatellite-stable locally adv…