Rectal Adenocarcinoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2026-04-01Clinical Trial Update: Adaptive Radiation for Locally Advanced Rectal Adenocarcinoma [EARLY_Phase 1]
This clinical trial update notes an EARLY Phase 1 study evaluating adaptive radiation for locally advanced rectal adenocarcinoma is currentl…
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CLINICAL_TRIALS trial_result · 2026-03-30Clinical Trial Update: Short Course Radiation Therapy and Combination Chemotherapy for the Treatment of Stage II-III Rectal Cancer [Phase 1]
Phase 1 trial evaluating short-course radiation therapy in combination with chemotherapy for stage II-III rectal cancer is currently recruit…
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CLINICAL_TRIALS trial_result · 2026-01-22Clinical Trial Update: Optimization of Adaptive Text Messages for Cancer Survivors (OATS II) [NA]
This update notes the completion of the OATS II trial evaluating adaptive text messaging for cancer survivors, with results posted on 2026-0…
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CLINICAL_TRIALS trial_result · 2025-12-19Clinical Trial Update: GRECCAR 8: Primary Tumor Resection in Rectal Cancer With Unresectable Metastasis [Phase 3]
Phase 3 GRECCAR 8 trial evaluating primary tumor resection in rectal cancer with unresectable metastases; the study status is completed.
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CLINICAL_TRIALS trial_result · 2025-11-20Clinical Trial Update: Encorafenib, Cetuximab, and Nivolumab in Treating Patients With Microsatellite Stable, BRAFV600E Mutated Unresectable or Metastatic Colorectal Cancer [Phase 1, Phase 2]
A Phase 1/2 clinical trial is evaluating a triple combination of encorafenib, cetuximab, and nivolumab in patients with microsatellite-stabl…
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CLINICAL_TRIALS trial_result · 2025-09-30Clinical Trial Update: Simultaneous Boost in Neoadjuvant Radiotherapy for Rectal Cancer [Phase 2]
Phase 2 clinical trial investigating simultaneous boost in neoadjuvant radiotherapy for locally advanced rectal adenocarcinoma; the trial is…
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CLINICAL_TRIALS trial_result · 2025-08-12Clinical Trial Update: Study Evaluating Two Treatment Strategies for Rectal Cancer in Patients ≥75 Years Old [Phase 3]
A Phase 3 trial evaluating two treatment strategies for locally advanced rectal adenocarcinoma in patients aged 75 years or older; the study…
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CLINICAL_TRIALS trial_result · 2025-06-08Clinical Trial Update: MoLiMoR - A Study With FOLFIRI-based First-line Therapy With or Without Intermittent Cetuximab [Phase 2]
A Phase 2 study (MoLiMoR) evaluated first-line FOLFIRI-based therapy with or without intermittent cetuximab in colon and rectal adenocarcino…
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CLINICAL_TRIALS trial_result · 2025-04-10Clinical Trial Update: Assessing the Additional Neoplasia Yield of Computer-aided Colonoscopy in a Screening Setting [NA]
This completed clinical trial evaluates whether computer-aided colonoscopy increases detection of neoplasia during colorectal cancer screeni…
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CLINICAL_TRIALS trial_result · 2025-03-27Clinical Trial Update: Can We Save the Rectum by Watchful Waiting or TransAnal Surgery Following (chemo)Radiotherapy Versus Total Mesorectal Excision for Early REctal Cancer? [Phase 2, Phase 3]
ClinicalTrials.gov entry for a Phase 2/3 study comparing watchful waiting or TransAnal surgery after (chemo)radiotherapy versus total mesore…
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CLINICAL_TRIALS trial_result · 2025-03-13Clinical Trial Update: Preoperative Short-course Radiation Followed by Envafolimab Plus CAPEOX for MSS Locally Advanced Rectal Adenocarcinoma (PRECAM) [Phase 2]
Phase 2 PRECAM trial evaluating preoperative short-course radiation followed by Envafolimab plus CAPEOX in microsatellite-stable locally adv…
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CLINICAL_TRIALS trial_result · 2025-01-21Clinical Trial Update: Evaluation of the Efficacy and Safety of Interleucin-2 Combined With PD-1 Monoclonal Antibody and CAPOX in Preoperative Neoadjuvant Therapy for Mid-low Locally Advanced Rectal Cancer - a Single-center, Single-arm, Open-label Clinical Trail [Phase 2]
Phase 2, single-arm study evaluating the safety and efficacy of combining Interleukin-2 with a PD-1 monoclonal antibody and CAPOX as neoadju…
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CLINICAL_TRIALS trial_result · 2024-12-05Clinical Trial Update: Comparison Between Tailored Surgery Versus Total Mesorectal Excision in ycT2-3N0M0 [NA]
A clinical trial comparing tailored surgery versus total mesorectal excision for ycT2-3N0M0 rectal adenocarcinoma has been terminated.
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CLINICAL_TRIALS trial_result · 2024-11-27Clinical Trial Update: M7824 in Patients With Metastatic Colorectal Cancer or With Advanced Solid Tumors With Microsatellite Instability [Phase 1, Phase 2]
Phase 1/2 clinical trial results for bintrafusp alfa (M7824) in metastatic colorectal cancer and MSI-H advanced solid tumors have been poste…
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CLINICAL_TRIALS trial_result · 2024-05-21Clinical Trial Update: Panitumumab, Regorafenib, or TAS-102, in Treating Patients With Metastatic and/or Unresectable RAS Wild-Type Colorectal Cancer [Phase 2]
Phase 2 clinical trial update evaluating panitumumab, regorafenib, and TAS-102 in patients with metastatic and/or unresectable RAS wild-type…
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CLINICAL_TRIALS trial_result · 2024-05-01Clinical Trial Update: Talimogene Laherparepvec, Chemotherapy, and Radiation Therapy Before Surgery in Treating Patients With Locally Advanced or Metastatic Rectal Cancer [Phase 1]
Phase 1 study of talimogene laherparepvec with chemotherapy and radiation before surgery in locally advanced or metastatic rectal cancer; th…
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CLINICAL_TRIALS trial_result · 2024-01-31Clinical Trial Update: Short-course Radiation Followed by mFOLFOX-6 Plus COMPOUND 2055269 for Locally-advanced Rectal Adenocarcinoma [Phase 2]
Phase 2 clinical trial update evaluating short-course radiation followed by mFOLFOX-6 plus COMPOUND 2055269 for locally advanced rectal aden…
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CLINICAL_TRIALS trial_result · 2023-10-05Clinical Trial Update: Testing the Addition of a Radiation Sensitizing Drug, IPdR, to the Usual Chemotherapy Treatment (Capecitabine) During Radiation Therapy for Rectal Cancer [Phase 1]
Phase 1 trial evaluating the addition of IPdR, a radiation-sensitizing drug, to standard capecitabine-based chemoradiation for locally advan…
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CLINICAL_TRIALS trial_result · 2023-08-08Clinical Trial Update: Savolitinib in Treating Patients With MET Amplified Metastatic or Unresectable Colorectal Cancer [Phase 2]
Phase 2 trial investigating savolitinib for MET-amplified metastatic or unresectable colorectal cancer was terminated with results posted.
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CLINICAL_TRIALS trial_result · 2023-06-09Clinical Trial Update: Veliparib, Pembrolizumab, and Combination Chemotherapy in Treating Patient With Locally Advanced Rectal Cancer [Phase 2]
Phase 2 trial evaluating veliparib plus pembrolizumab and chemotherapy in locally advanced rectal cancer has completed and posted results in…
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CLINICAL_TRIALS trial_result · 2022-11-17Clinical Trial Update: Mechanical Bowel Preparation and Oral Antibiotics Versus Mechanical Bowel Preparation Only Prior Rectal Surgery [Phase 4]
Phase 4 clinical trial evaluating mechanical bowel preparation with oral antibiotics versus mechanical bowel preparation alone prior to rect…
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CLINICAL_TRIALS trial_result · 2021-12-01Clinical Trial Update: A Phase I Study of AZD6244 in Combination With Capecitabine and Radiotherapy in Locally Advanced Adenocarcinoma of the Rectum [Phase 1]
Phase I study evaluating AZD6244 with capecitabine and radiotherapy in non-metastatic rectal adenocarcinoma; the trial was terminated with r…
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CLINICAL_TRIALS trial_result · 2021-11-04Clinical Trial Update: Pelvic Radiotherapy With Concurrent Neoadjuvant FOLFOX for Patients With Newly Diagnosed Rectal Adenocarcinoma [Phase 2]
Phase 2 trial investigating pelvic radiotherapy with concurrent neoadjuvant FOLFOX for newly diagnosed rectal adenocarcinoma; study terminat…
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CLINICAL_TRIALS trial_result · 2020-11-09Clinical Trial Update: A Trial of Durvalumab (MEDI 4736) in Combination With Extended Neoadjuvant Regimens in Rectal Cancer [Phase 2]
Phase 2 trial investigating durvalumab in combination with extended neoadjuvant regimens for rectal cancer; status currently unknown.
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CLINICAL_TRIALS trial_result · 2020-07-07Clinical Trial Update: Nintedanib and Capecitabine in Treating Patients With Refractory Metastatic Colorectal Cancer [Phase 1, Phase 2]
Phase 1/2 study evaluating nintedanib with capecitabine in refractory metastatic colorectal cancer has completed with posted results.