Rectal Adenocarcinoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2025-09-30Clinical Trial Update: SCRT Followed by CAPOX + Bev ± PD-1 Inhibitor for TNT in LARC [Phase 2]
A Phase 2 trial in locally advanced rectal cancer is testing total neoadjuvant therapy with short-course radiotherapy followed by CAPOX and …
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CLINICAL_TRIALS research · 2025-09-29Clinical Trial Update: Safety of a Boost (CXB or EBRT) in Combination With Neoadjuvant Chemoradiotherapy for Early Rectal Adenocarcinoma [Phase 3]
Phase 3 trial evaluating the safety of adding a boost with CXB or external beam radiotherapy to neoadjuvant chemoradiotherapy for early rect…
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CLINICAL_TRIALS research · 2025-09-25Clinical Trial Update: Establishing a ctDNA Biomarker to Improve Organ Preserving Strategies in Patients With Rectal Cancer
This clinical trial update outlines a study to establish a circulating tumor DNA biomarker to improve organ-preserving strategies in rectal …
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CLINICAL_TRIALS research · 2025-09-16Clinical Trial Update: xDRIVE in Metastatic Colorectal Cancer
The clinical trial update indicates the xDRIVE therapy for metastatic colorectal cancer is not yet recruiting.
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CLINICAL_TRIALS research · 2025-09-16Clinical Trial Update: Family Communications After Genetic Testing [NA]
A NOT_YET_RECRUITING clinical trial update from the Alliance for Clinical Trials in Oncology studying family communications after genetic te…
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CLINICAL_TRIALS research · 2025-09-15Clinical Trial Update: Involve-site Radiotherapy Combined With Chemotherapy and Immunotherapy as Neoadjuvant Treatment for Locally Advanced Rectal Cancer [Phase 2]
This update describes a Phase 2 clinical trial evaluating involve-site radiotherapy in combination with chemotherapy and immunotherapy as ne…
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CLINICAL_TRIALS research · 2025-09-02Clinical Trial Update: Nordic ORgan Preservation Pilot Approach Nonrandomised Single-Arm Trial for Non-Operative Management of Rectal Cancer [NA]
This clinical trial update describes a Nordic organ preservation pilot for rectal cancer using non-operative management. It is a nonrandomis…
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CLINICAL_TRIALS research · 2025-08-08Clinical Trial Update: Study on the Efficacy and Safety of Neoadjuvant Radiotherapy Combined With Toripalimab, Liposomal Irinotecan, and Capecitabine in the Treatment of pMMR Locally Advanced Rectal Adenocarcinoma With Low Rectal Involvement [Phase 1]
Phase 1 clinical trial evaluating a neoadjuvant regimen combining radiotherapy with toripalimab, liposomal irinotecan, and capecitabine for …
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CLINICAL_TRIALS research · 2025-08-07Clinical Trial Update: ADAR1 Expression Level in Rectal Cancer
A recruiting clinical trial at Necmettin Erbakan University is investigating ADAR1 expression levels in rectal cancer.
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CLINICAL_TRIALS research · 2025-08-06Clinical Trial Update: A Study On The Prediction of Neoadjuvant Efficacy For Rectal Cancer Based On MR Cytometry Imaging and Deep-radiomics
Clinical trial evaluating whether MR cytometry imaging and deep radiomics can predict neoadjuvant treatment efficacy in rectal cancer. The s…
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CLINICAL_TRIALS research · 2025-07-18Clinical Trial Update: Papaverine in Combination With Radiation Therapy for the Treatment of Locally Advanced Rectal Cancer, DINOMITE Trial [Phase 1]
The DINOMITE Phase 1 trial is evaluating papaverine in combination with radiation therapy for locally advanced rectal cancer and is currentl…
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CLINICAL_TRIALS research · 2025-06-26Clinical Trial Update: FOLFOX, Botensilimab, and Balstilimab for the Treatment of Localized Rectal Cancer Before Surgery [Phase 2]
Phase 2 clinical trial evaluating FOLFOX with Botensilimab and Balstilimab for localized rectal cancer before surgery is currently recruitin…
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CLINICAL_TRIALS research · 2025-05-22Clinical Trial Update: Evaluating Novel Therapies in ctDNA Positive GI Cancers [Phase 3]
Georgetown University is conducting a Phase 3 trial evaluating novel therapies for ctDNA-positive gastrointestinal cancers, currently recrui…
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CLINICAL_TRIALS research · 2025-04-09Clinical Trial Update: A Phase ll Study of Neoadjuvant Short-course Radiotherapy Followed by Ivonescimab and Chemotherapy in pMMR/MSS Locally Advanced Rectal Cancer [Phase 2]
Phase II neoadjuvant radiotherapy followed by Ivonescimab and chemotherapy for locally advanced pMMR/MSS rectal adenocarcinoma; current stat…
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CLINICAL_TRIALS research · 2025-03-12Clinical Trial Update: Short-Course Radiotherapy Combined with Intracavitary Brachytherapy Followed by Pucotenlimab, Bevacizumab, Oxaliplatin, and Trifluridine/Tipiracil (TAS-102) for Total Neoadjuvant Therapy of Microsatellite Stable (MSS) Locally Advanced Low Rectal Cancer [Phase 2]
Phase 2 trial evaluating total neoadjuvant therapy for microsatellite-stable locally advanced low rectal cancer using short-course radiother…
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CLINICAL_TRIALS research · 2025-03-03Clinical Trial Update: Dose Escalated Radiotherapy for Rectal Cancers Using MR-guided Radiotherapy [NA]
A clinical trial evaluating dose-escalated MR-guided radiotherapy for rectal adenocarcinoma, sponsored by Royal Marsden NHS Foundation Trust…
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CLINICAL_TRIALS research · 2025-02-18Clinical Trial Update: PRODIGE 90 - (FFCD 2204) Neoadjuvant Dostarlimab with Short Course Radiotherapy in a Watch-and-wait Strategy for Microsatellite Unstable or Mismatch Repair-deficient Locally Advanced Rectal Cancer Patients [Phase 3]
Phase 3 trial evaluating neoadjuvant dostarlimab with short-course radiotherapy in a watch-and-wait strategy for mismatch repair-deficient o…
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CLINICAL_TRIALS research · 2024-11-20Clinical Trial Update: Asian Watch-and-Wait Database (AWWD)
A clinical trial update for the Asian Watch-and-Wait Database (AWWD) sponsored by Tata Memorial Centre for rectal cancer/rectal adenocarcino…
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CLINICAL_TRIALS research · 2024-10-17Clinical Trial Update: Concordance of Imaging and Pathology Diagnosis of Extranodal Tumour Deposits [NA]
Clinical trial update indicating the study on concordance of imaging and pathology diagnosis of extranodal tumour deposits in rectal adenoca…
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CLINICAL_TRIALS research · 2024-07-29Clinical Trial Update: Effect of Pelvic Rehabilitation After Low Anterior Resection for Cancer Rectum. - A Randomised Controlled Trial [NA]
A randomized controlled trial evaluating pelvic rehabilitation after low anterior resection for rectal cancer; the study is not yet recruiti…
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CLINICAL_TRIALS research · 2018-05-15Clinical Trial Update: Evaluation of Rectal Tumor Margin Using Confocal Endomicroscopy and Comparison to Histopathology [NA]
A terminated clinical trial evaluating rectal tumor margin assessment with confocal endomicroscopy and comparing results to histopathology, …
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CLINICAL_TRIALS research · 2017-02-03Clinical Trial Update: Investigation of the Value of ctDNA in Diagnosis, Treatment, and Surveillance of Surgically Resectable Colorectal Cancer [Phase 3]
Phase 3 clinical trial assessing whether circulating tumor DNA can aid diagnosis, guide treatment decisions, and monitor recurrence in surgi…
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CLINICAL_TRIALS research · 2017-02-03Clinical Trial Update: Multicenter, Prospective, RCT：Investigation of Combined Modality Therapy for Locally Advanced Mid/Low Rectal Cancer. [NA]
This document reports a multicenter, prospective randomized trial investigating combined modality therapy for locally advanced mid/low recta…
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CLINICAL_TRIALS research · 2013-08-07Clinical Trial Update: J-Pouch Coloanal Anastomosis Compared With Side-to-End Coloanal Anastomosis After Radiation Therapy and Surgery to Remove the Rectum in Treating Patients With Rectal Adenocarcinoma [Phase 3]
Phase 3 clinical trial comparing J-pouch coloanal anastomosis with side-to-end coloanal anastomosis after radiation therapy and rectal remov…
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CLINICAL_TRIALS research · 2013-04-25Clinical Trial Update: Extralevator Versus Standard Abdominoperineal Resection For Rectal Adenocarcinoma [NA]
This entry provides an update on a clinical trial comparing extralevator versus standard abdominoperineal resection for rectal adenocarcinom…