Pulmonary Hypertension
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2019-08-13Clinical Trial Update: Clinical Study of Adipose Derived Mesenchymal Stem Cells for Treatment of Pulmonary Arterial Hypertension [Phase 1, Phase 2]
A clinical trial investigating adipose-derived mesenchymal stem cells for pulmonary arterial hypertension across Phase 1 and Phase 2.
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CLINICAL_TRIALS trial_result · 2019-05-22Clinical Trial Update: Safety and Efficacy Trial to Treat Diastolic Heart Failure Using Ambrisentan [Phase 4]
Phase 4 trial evaluating safety and efficacy of ambrisentan for diastolic heart failure (heart failure with preserved ejection fraction) in …
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CLINICAL_TRIALS trial_result · 2019-05-15Clinical Trial Update: Clinical Study to Evaluate the Safety and Tolerability of Macitentan in Subjects With Combined Pre- and Post-capillary Pulmonary Hypertension (CpcPH) Due to Left Ventricular Dysfunction [Phase 2]
Phase 2 clinical trial assessing safety and tolerability of macitentan in subjects with combined pre- and post-capillary pulmonary hypertens…
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CLINICAL_TRIALS research · 2019-04-05Clinical Trial Update: Real-time MRI Right Heart Catheterization Using Passive Catheters [Phase 1, Phase 2]
A Phase 1/2 clinical trial update on real-time MRI-guided right heart catheterization using passive catheters for cardiovascular conditions.
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CLINICAL_TRIALS trial_result · 2019-03-13Clinical Trial Update: Sildenafil in Heart Failure With Reactive Pulmonary Hypertension [Phase 4]
A Phase 4 trial of sildenafil in heart failure with reactive pulmonary hypertension was terminated; results posted in 2019.
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CLINICAL_TRIALS trial_result · 2019-03-12Clinical Trial Update: Inhaled Nitrite in Subjects With Pulmonary Hypertension [Phase 2]
Phase 2 clinical trial update evaluating inhaled nitrite in subjects with pulmonary hypertension and diastolic heart failure; study complete…
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CLINICAL_TRIALS trial_result · 2019-02-26Clinical Trial Update: Targeting Right Ventricle in Pulmonary Hypertension Gilead [Phase 4]
Phase 4 trial summary posted for a pulmonary hypertension study targeting the right ventricle, completed with results available in 2019.
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CLINICAL_TRIALS trial_result · 2019-02-21Clinical Trial Update: Riociguat Clinical Effects Studied in Patients With Insufficient Treatment Response to Phosphodiesterase-5 Inhibitor [Phase 3]
Riociguat was studied in a Phase 3 clinical trial for patients with pulmonary hypertension who had insufficient response to PDE-5 inhibitors…
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FDA approval · 2019-02-13FDA Approved: INOMAX — Supplemental Application (INO Therapeutics LLC)
The FDA approved a supplemental application for INOMAX (nitric oxide) submitted by INO Therapeutics LLC.
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CLINICAL_TRIALS trial_result · 2019-02-05Clinical Trial Update: 11C-acetate/18Fluorodeoxyglucose-FDG PET/CT and Cardiac MRI in Pulmonary Hypertension [Phase 2]
Phase 2 clinical trial update reporting results from imaging studies using 11C-acetate and 18F-FDG PET/CT plus cardiac MRI in patients with …
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CLINICAL_TRIALS research · 2019-02-04Clinical Trial Update: Role of the Nitric Oxide (NO) in Pre-oxygenation Before Anesthetic Induction in Patients With a Pulmonary Hypertension in Cardiac Surgery. Pilot Study of Feasibility [Phase 2]
A Phase 2 pilot feasibility study evaluating inhaled nitric oxide to aid pre-oxygenation before anesthesia induction in patients with pulmon…
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CLINICAL_TRIALS trial_result · 2019-01-22Clinical Trial Update: A Phase 1 Relative Bioavailability Study of Ambrisentan and Tadalfil Fixed Dose Combination Tablets in Healthy Subjects [Phase 1]
This Phase 1 study evaluated the relative bioavailability of a fixed-dose combination tablet of ambrisentan and tadalafil in healthy subject…
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CLINICAL_TRIALS trial_result · 2019-01-09Clinical Trial Update: Sildenafil in Hemodialysis Patients With Pulmonary Hypertension [Phase 2, Phase 3]
Phase 2/3 trial evaluating sildenafil in patients on hemodialysis with pulmonary hypertension; status not specified.
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CLINICAL_TRIALS trial_result · 2018-12-19Clinical Trial Update: Targeting the Right Ventricle in Pulmonary Hypertension [Phase 4]
Phase 4 clinical trial update reporting completed results on therapies aimed at improving right-ventricular function in pulmonary hypertensi…
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CLINICAL_TRIALS withdrawal · 2018-12-07Clinical Trial Update: Efficacy and Safety of Combination Ambrisentan and Tadalafil in Patients With Portopulmonary Hypertension [Phase 4]
Phase 4 trial evaluating ambrisentan plus tadalafil for portopulmonary hypertension has been withdrawn.
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CLINICAL_TRIALS trial_result · 2018-11-07Clinical Trial Update: Natrecor in Pulmonary Hypertension [Phase 4]
Phase 4 clinical trial update for Natrecor in pulmonary hypertension; study terminated.
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CLINICAL_TRIALS trial_result · 2018-10-31Clinical Trial Update: A Multiple Dose Titration Study of MK-8892 in Participants With Pulmonary Hypertension and Left Heart Disease (MK-8892-007) [Phase 1]
Phase 1 multiple-dose titration study of MK-8892 in participants with pulmonary hypertension and left heart disease was terminated; results …
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CLINICAL_TRIALS trial_result · 2018-10-24Clinical Trial Update: The Role of Endothelin in Pulmonary Hypertension [Phase 2]
Phase 2 clinical trial update examining the role of endothelin in pulmonary hypertension has completed with results posted.
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EMA withdrawal · 2018-09-21EMA Application withdrawn: Treprostinil SciPharm Sàrl (treprostinil) — SciPharm Sàrl
The EMA indicates that the application for treprostinil by SciPharm Sàrl has been withdrawn.
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CLINICAL_TRIALS trial_result · 2018-08-27Clinical Trial Update: L-arginine Versus Sildenafil in Children With Beta Thalassemia Associated With Pulmonary Hypertension [Phase 4]
Phase 4 trial comparing L-arginine to sildenafil in children with beta thalassemia and pulmonary hypertension.
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CLINICAL_TRIALS trial_result · 2018-08-02Clinical Trial Update: Ambrisentan (Letairis) for Sarcoidosis Associated Pulmonary Hypertension [Phase 2, Phase 3]
Clinical trial update on ambrisentan (Letairis) for sarcoidosis-associated pulmonary hypertension; study phases 2 and 3 completed.
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CLINICAL_TRIALS trial_result · 2018-07-13Clinical Trial Update: Phase 2 Study of Ex-vivo Perfusion and Ventilation of Lungs to Assess Transplant Suitability [NA]
Phase 2 trial evaluating ex-vivo lung perfusion and ventilation to assess transplant suitability, sponsored by the University of North Carol…
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CLINICAL_TRIALS trial_result · 2018-07-11Clinical Trial Update: The Exercise Capacity and Quality of Life in the Patients With IPAH and Secondary PH
A completed clinical trial evaluating exercise capacity and quality of life in patients with idiopathic pulmonary arterial hypertension and …
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CLINICAL_TRIALS trial_result · 2018-07-09Clinical Trial Update: Study of the Efficacy and Safety of Tezosentan in Patients With Pre-operative Pulmonary Hypertension, Due to Left Heart Disease, Undergoing Open Heart Surgery [Phase 3]
A Phase 3 study evaluating the efficacy and safety of tezosentan in patients with pre-operative pulmonary hypertension due to left heart dis…
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CLINICAL_TRIALS withdrawal · 2018-07-05Clinical Trial Update: Imatinib and Carvedilol for High Blood Pressure in the Lungs in Adults With Sickle Cell Disease [Phase 1]
Phase 1 clinical trial of imatinib and carvedilol for pulmonary hypertension in adults with sickle cell disease has been withdrawn.