Immunodeficiency
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CLINICAL_TRIALS research · 2025-02-12Clinical Trial Update: Developing a Patient-Reported Outcome (PRO) Screening Measure for Infections and Measuring Quality of Life in Hematological Patients With Secondary Immunodeficiency (SID) Across the Treatment Trajectory - The PRO SID Project
This clinical trial update describes the PRO SID Project, which aims to develop and validate a patient-reported outcome screening measure fo…
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CLINICAL_TRIALS research · 2025-01-28Clinical Trial Update: Observational Study of Subcutaneous Immunoglobulin (Cutaquig) in Patients With Primary and Secondary Immunodeficiency.
An observational study evaluating subcutaneous immunoglobulin Cutaquig in patients with primary and secondary immunodeficiency; the trial is…
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CLINICAL_TRIALS trial_result · 2025-01-16Clinical Trial Update: Expanded Access Protocol Thymus Transplantation [Phase 4]
Expanded Access Protocol Thymus Transplantation (Phase 4) has posted results for patients with poor thymic function and immunodeficiency. Th…
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CLINICAL_TRIALS research · 2025-01-14Clinical Trial Update: Immunodysregulation As an Expression of Underlying Inborn Errors of Immunity: Implementation of Diagnostics and Management of Pediatric and Adult Patients with Immune System Disorders
A clinical study evaluating diagnostic approaches and management strategies for pediatric and adult patients with immune system disorders ca…
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CLINICAL_TRIALS trial_result · 2025-01-08Clinical Trial Update: Aerobic Exercises Versus Laser Puncture on Immune Response Following Neck Lymph Node Dissection [NA]
A completed clinical trial comparing aerobic exercise versus laser puncture to evaluate immune response after neck lymph node dissection.
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CLINICAL_TRIALS trial_result · 2024-11-25Clinical Trial Update: A Study of TAK-771 in Japanese People With Primary Immunodeficiency Diseases (PID) [Phase 3]
Phase 3 trial of TAK-771 in Japanese participants with primary immunodeficiency has completed and results have been posted.
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CLINICAL_TRIALS trial_result · 2024-10-01Clinical Trial Update: COVID-19 Vaccination and Outcomes in Individuals With and Without Immune Deficiencies and Dysregulations
A completed clinical trial evaluating COVID-19 vaccination outcomes in individuals with and without immunodeficiencies and immune dysregulat…
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CLINICAL_TRIALS withdrawal · 2024-09-19Clinical Trial Update: Evaluation of Post-SARS-CoV-2 Vaccinal Response in Immunocompromised Patients [NA]
A clinical trial evaluating the post-vaccinal immune response to SARS-CoV-2 vaccines in immunocompromised patients has been withdrawn. Spons…
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CLINICAL_TRIALS research · 2024-08-21Clinical Trial Update: Immune Homeostasis in Sepsis and Septic Shock
A clinical trial from Charles University is investigating immune homeostasis in sepsis and septic shock and is currently recruiting.
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CLINICAL_TRIALS trial_result · 2024-07-15Clinical Trial Update: PREP (Pre-Exposure Prophylaxis) of COVID-19
This is a completed clinical trial update for PREP (Pre-Exposure Prophylaxis) of COVID-19. The study involves individuals with immunodeficie…
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CLINICAL_TRIALS trial_result · 2024-07-09Clinical Trial Update: Rapamycin Treatment for Activated Phosphoinositide 3-Kinase δ Syndrome [Phase 1, Phase 2]
This document reports the completion of a Phase 1/2 trial evaluating rapamycin for Activated PI3K-delta syndrome (APDS), a primary immunodef…
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CLINICAL_TRIALS trial_result · 2024-06-04Clinical Trial Update: Nutrition, Immunity, and Covid-19 in Obese People [Phase 2]
This is a Phase 2 clinical trial update from Indonesia University evaluating how nutrition and vitamin D status influence immunity in obese …
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CLINICAL_TRIALS trial_result · 2023-09-26Clinical Trial Update: Long Term Follow-up Study for Patients Enrolled on the BP-004 Clinical Study [Phase 1, Phase 2]
Long-term follow-up update from BP-004 study (Phase 1/Phase 2) by Bellicum Pharmaceuticals; study status TERMINATED with results posted in 2…
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CLINICAL_TRIALS trial_result · 2023-08-07Clinical Trial Update: A Study to Evaluate IGSC 20% Biweekly Dosing in Treatment-Experienced Participants and Loading/Maintenance Dosing in Treatment-Naïve Participants With Primary Immunodeficiency [Phase 4]
Phase 4 trial evaluating IGSC 20% biweekly dosing in treatment-experienced and loading/maintenance dosing in treatment-naïve participants wi…
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CLINICAL_TRIALS trial_result · 2023-06-05Clinical Trial Update: A Study to Evaluate the Pharmacokinetics, Safety, and Tolerability of Immune Globulin (Human) 10% (Gamunex-C) PEG Process (IVIG-PEG) Compared to Gamunex-C in Participants With Primary Humoral Immunodeficiency [Phase 3]
Phase 3 study comparing IVIG-PEG to standard Gamunex-C in people with primary immunodeficiency; results completed with posted results.
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CLINICAL_TRIALS trial_result · 2023-01-04Clinical Trial Update: Safety Study of Gene Modified Donor T-cells Following TCRαβ+ Depleted Stem Cell Transplant [Phase 1, Phase 2]
A phase 1/2 safety study evaluating gene-modified donor T-cells after TCRαβ+ depleted stem cell transplant was terminated; results were post…
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CLINICAL_TRIALS trial_result · 2021-08-20Clinical Trial Update: Study of ProMetic BioTherapeutics Immune Globulin Intravenous (Human) 10% [Phase 3]
Phase 3 trial update for ProMetic BioTherapeutics' intravenous immunoglobulin (10%) in primary immunodeficiency has completed with results p…
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CLINICAL_TRIALS trial_result · 2021-06-29Clinical Trial Update: Non-Interventional Study on the Tolerability and Efficacy of IVIG
A completed non-interventional study evaluating tolerability and efficacy of Octagam IVIG in primary and secondary immunodeficiency and othe…
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CLINICAL_TRIALS trial_result · 2021-04-08Clinical Trial Update: Preemptive Use of Convalescent Plasma for High-risk Patients With COVID-19 [Phase 3]
A Phase 3 clinical trial update on preemptive use of convalescent plasma for high-risk COVID-19 patients, status not yet determined.
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CLINICAL_TRIALS trial_result · 2021-02-16Clinical Trial Update: Efficacy and Safety Study of Kedrion IVIG 10% to Treat Subjects With Primary Immunodeficiency (PID) [Phase 3]
A Phase 3 study evaluating Kedrion IVIG 10% for efficacy and safety in subjects with primary immunodeficiency shows completed status with re…
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CLINICAL_TRIALS trial_result · 2020-06-16Clinical Trial Update: Efficacy, Pharmacokinetics, Safety, and Tolerability of IGSC 20% in Subjects With Primary Immunodeficiency [Phase 3]
Phase 3 trial evaluating efficacy, pharmacokinetics, safety, and tolerability of IGSC 20% in subjects with primary immunodeficiency.
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CLINICAL_TRIALS withdrawal · 2020-04-10Clinical Trial Update: Study Evaluating IGSC 20% Flexible Dosing in Treatment-Experienced and Treatment-Naive Subjects With Primary Immunodeficiency [Phase 3]
Clinical trial evaluating IGSC 20% for primary immunodeficiency was withdrawn.
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CLINICAL_TRIALS trial_result · 2020-03-04Clinical Trial Update: Safety, Tolerability, Patient Satisfaction and Cost of 16.5% Subcutaneous Immunoglobulin (Cutaquig®) Treatment [Phase 4]
Phase 4 trial assessing safety, tolerability, patient satisfaction, and cost of 16.5% subcutaneous immunoglobulin (Cutaquig) for primary and…
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CLINICAL_TRIALS trial_result · 2020-01-13Clinical Trial Update: Safety and Tolerability of Higher Infusion Parameters of IgPro20 (Hizentra) in Subjects With Primary Immunodeficiency (PID) [Phase 4]
Phase 4 trial assessing safety and tolerability of higher infusion parameters of Hizentra (IgPro20) in patients with primary immunodeficienc…
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CLINICAL_TRIALS trial_result · 2019-11-15Clinical Trial Update: Comparison of Multigam IV (5% vs. 10%) in Patients With an Immunodeficiency Secondary to a Hematological Disorder
A completed clinical trial comparing 5% vs 10% Multigam IV in patients with immunodeficiency due to a hematologic disorder; results posted i…