Hyperoxaluria
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CLINICAL_TRIALS trial_result · 2026-04-16Clinical Trial Update: Nedosiran in Pediatric Patients From Birth to 11 Years of Age With PH and Relatively Intact Renal Function [Phase 2]
Phase 2 trial update showing results for Nedosiran in pediatric patients from birth to 11 years with Primary Hyperoxaluria (Types 1–3); the …
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CLINICAL_TRIALS trial_result · 2026-02-06Clinical Trial Update: A Novel Approach for Reducing Hyperoxaluria and Kidney Stone Risk. [Phase 4]
This Phase 4 clinical trial update reports completion of a study evaluating a novel approach to reduce hyperoxaluria and lower kidney stone …
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: Study of DCR-PHXC-101 in Normal Healthy Volunteers and Patients With Primary Hyperoxaluria [Phase 1]
A Phase 1 study evaluating DCR-PHXC-101 in normal healthy volunteers and patients with Primary Hyperoxaluria has completed, focusing on safe…
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CLINICAL_TRIALS trial_result · 2023-10-23Clinical Trial Update: Dapagliflozin and Hydrochlorothiazide in Recurring Kidney Stone Patients [Phase 4]
Phase 4 trial update on dapagliflozin and hydrochlorothiazide in patients with recurring kidney stones (urolithiasis) and hyperoxaluria; sta…
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CLINICAL_TRIALS trial_result · 2022-07-12Clinical Trial Update: A Study to Evaluate Lumasiran in Patients With Advanced Primary Hyperoxaluria Type 1 [Phase 3]
A Phase 3 study evaluating Lumasiran for advanced Primary Hyperoxaluria Type 1 has completed and posted results.
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CLINICAL_TRIALS trial_result · 2021-12-09Clinical Trial Update: A Study to Evaluate the Efficacy and Safety of Oxabact in Patients With Primary Hyperoxaluria [Phase 3]
Phase 3 trial evaluating Oxabact for primary hyperoxaluria has completed; results posted in 2021.
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CLINICAL_TRIALS trial_result · 2021-12-09Clinical Trial Update: Study to Evaluate the Efficacy and Safety of Oxabact (OC5) in Primary Hyperoxaluria Patients Who Are on Dialysis [Phase 2]
A Phase 2 trial evaluating Oxabact (OC5) for efficacy and safety in patients with primary hyperoxaluria on dialysis has completed, with resu…
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CLINICAL_TRIALS trial_result · 2021-12-08Clinical Trial Update: An Extension Study to Evaluate the Long-term Efficacy and Safety of Oxabact in Patients With Primary Hyperoxaluria [Phase 3]
An extension study of Oxabact in primary hyperoxaluria (Phase 3) has been terminated; results posted in 2021. Long-term efficacy and safety …
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CLINICAL_TRIALS trial_result · 2021-03-26Clinical Trial Update: Evaluation of the Efficacy of Stiripentol (Diacomit) as Monotherapy for the Treatment of Primary Hyperoxaluria [Phase 2]
Phase 2 clinical trial evaluating stiripentol (Diacomit) as monotherapy for primary hyperoxaluria has completed.
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CLINICAL_TRIALS trial_result · 2021-01-08Clinical Trial Update: Lanthanum Carbonate (Fosrenol®) to Reduce Oxalate Excretion in Patients With Secondary Hyperoxaluria and Nephrolithiasis [Phase 3]
Phase 3 trial investigating lanthanum carbonate (Fosrenol) to reduce oxalate excretion in patients with secondary hyperoxaluria and nephroli…
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CLINICAL_TRIALS trial_result · 2020-12-30Clinical Trial Update: Study of ALLN-177 in Patients Aged 12 Years or Older With Enteric or Primary Hyperoxaluria and Hyperoxalemia [Phase 2]
Phase 2 trial update for ALLN-177 in patients aged 12 and older with enteric or primary hyperoxaluria and hyperoxalemia has completed.
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CLINICAL_TRIALS trial_result · 2020-03-24Clinical Trial Update: A Pilot Study of Oxalate Absorption in Secondary Hyperoxaluria [NA]
A completed pilot trial evaluating oxalate absorption in secondary hyperoxaluria; results posted.
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CLINICAL_TRIALS trial_result · 2018-01-11Clinical Trial Update: Evaluate the Effect of ALLN-177 in Reducing Urinary Oxalate in Patients With Hyperoxaluria and Kidney Stones [Phase 2]
Phase 2 trial evaluating ALLN-177 for reducing urinary oxalate in patients with hyperoxaluria and kidney stones has completed.
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CLINICAL_TRIALS trial_result · 2017-07-02Clinical Trial Update: Hydroxyproline Influence on Oxalate Metabolism [Phase 1, Phase 2]
Phase 1 and Phase 2 trials evaluated the effect of hydroxyproline on oxalate metabolism in hyperoxaluria. Results were posted after completi…
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CLINICAL_TRIALS trial_result · 2017-01-19Clinical Trial Update: Evaluate the Effect of ALLN-177 in Reducing Urinary Oxalate in Patients With Secondary Hyperoxaluria and Kidney Stones Over 28 Days [Phase 2]
Phase 2 trial evaluating ALLN-177 for reducing urinary oxalate in patients with secondary hyperoxaluria and nephrolithiasis over 28 days; th…
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CLINICAL_TRIALS trial_result · 2016-10-27Clinical Trial Update: Effect of Over-the-counter Dietary Supplements on Kidney Stone Risk [NA]
A completed clinical trial investigated the effect of over-the-counter dietary supplements on kidney stone risk in individuals with hyperoxa…
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CLINICAL_TRIALS trial_result · 2016-07-07Clinical Trial Update: Primary Hyperoxaluria Mutation Genotyping
A completed Mayo Clinic clinical trial update focusing on mutation genotyping for Primary hyperoxaluria.
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CLINICAL_TRIALS trial_result · 2016-04-27Clinical Trial Update: Evaluating ALLN-177 for Reducing Urinary Oxalate Excretion in Calcium Oxalate Kidney Stone Formers With Hyperoxaluria [Phase 2]
Phase 2 clinical trial evaluating ALLN-177 to reduce urinary oxalate excretion in adults with hyperoxaluria and kidney stones has completed …
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CLINICAL_TRIALS trial_result · 2015-10-16Clinical Trial Update: Study to Evaluate the Efficacy and Safety of Oxabact (OC5) in Patients With Primary Hyperoxaluria [Phase 1, Phase 2]
This clinical trial update reports on the Phase 1/2 study of Oxabact (OC5) for Primary Hyperoxaluria assessing efficacy and safety; the stud…
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CLINICAL_TRIALS trial_result · 2013-05-15Clinical Trial Update: Study to Evaluate the Efficacy and Safety of OxabactTM on Reduction of Urinary Oxalate in Primary Hyperoxaluria Patients [Phase 2, Phase 3]
A study evaluating the efficacy and safety of Oxabact in reducing urinary oxalate in patients with primary hyperoxaluria has completed Phase…
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CLINICAL_TRIALS trial_result · 2013-05-15Clinical Trial Update: Phase 2/3 Oxabact Study [Phase 2, Phase 3]
Phase 2/3 trial of Oxabact for primary hyperoxaluria has completed.
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CLINICAL_TRIALS trial_result · 2013-04-16Clinical Trial Update: Comparison of DASH With Oxalate Restricted Diet on Urine in Recurrent Stone Formers With Hyperoxaluria [NA]
This entry notes the completion of a clinical trial comparing a DASH diet with an oxalate-restricted diet and their effects on urine in recu…
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CLINICAL_TRIALS trial_result · 2012-12-24Clinical Trial Update: Oxazyme in Patients With Hyperoxaluria [Phase 1, Phase 2]
Oxazyme was studied in patients with hyperoxaluria in Phase 1 and Phase 2 trials. The trials have completed and results were posted in Decem…
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CLINICAL_TRIALS trial_result · 2012-05-31Clinical Trial Update: Use of Oral Probiotics to Reduce Urinary Oxalate Excretion [Phase 1, Phase 2]
A Mayo Clinic-sponsored phase 1/2 clinical trial assessed an oral probiotic to lower urinary oxalate excretion in nephrolithiasis and hypero…