Hyperoxaluria
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2026-04-16Clinical Trial Update: Nedosiran in Pediatric Patients From Birth to 11 Years of Age With PH and Relatively Intact Renal Function [Phase 2]
Phase 2 trial update showing results for Nedosiran in pediatric patients from birth to 11 years with Primary Hyperoxaluria (Types 1–3); the …
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CLINICAL_TRIALS trial_result · 2026-02-06Clinical Trial Update: A Novel Approach for Reducing Hyperoxaluria and Kidney Stone Risk. [Phase 4]
This Phase 4 clinical trial update reports completion of a study evaluating a novel approach to reduce hyperoxaluria and lower kidney stone …
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CLINICAL_TRIALS research · 2025-12-30Clinical Trial Update: Validation Testing for Plasma Oxalate Levels in the Biochemical Laboratory at the Galilee Medical Center, in Collaboration With the Biochemistry Laboratory at CHARITE Hospital in Berlin, and Testing the Relationship Between Oxalate Levels and Vitamin C Levels in Plasma
A clinical trial update describing validation testing for plasma oxalate levels and investigating the relationship between oxalate and vitam…
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EMA approval · 2025-10-13EMA Authorised: Oxlumo (Lumasiran sodium) — Alnylam Netherlands B.V.
The European Medicines Agency has authorised Oxlumo (lumasiran sodium) for primary hyperoxaluria, an orphan disease, with marketing authoriz…
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CLINICAL_TRIALS research · 2025-08-06Clinical Trial Update: Prospective Research Rare Kidney Stones (ProRKS)
A Mayo Clinic-led clinical trial (ProRKS) is currently recruiting for rare kidney stone conditions including hyperoxaluria, cystinuria, Dent…
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CLINICAL_TRIALS research · 2025-07-22Clinical Trial Update: Rare Kidney Stone Consortium Biobank
This update notes that the Rare Kidney Stone Consortium Biobank, sponsored by Mayo Clinic, is currently recruiting to collect samples for ra…
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CLINICAL_TRIALS research · 2025-07-04Clinical Trial Update: Rare Kidney Stone Consortium Patient Registry
A Mayo Clinic-sponsored Rare Kidney Stone Consortium patient registry is actively recruiting to collect data on patients with rare kidney st…
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CLINICAL_TRIALS research · 2025-03-03Clinical Trial Update: Oxalate Excretion Profile in Patients with a Heterozygous Mutation of the AGXT (alanine-glyoxylate Aminotransferase) Gene [NA]
A recruiting clinical trial studying oxalate excretion in patients with a heterozygous AGXT gene mutation, related to primary hyperoxaluria …
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CLINICAL_TRIALS trial_result · 2024-09-19Clinical Trial Update: Study of DCR-PHXC-101 in Normal Healthy Volunteers and Patients With Primary Hyperoxaluria [Phase 1]
A Phase 1 study evaluating DCR-PHXC-101 in normal healthy volunteers and patients with Primary Hyperoxaluria has completed, focusing on safe…
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CLINICAL_TRIALS withdrawal · 2024-06-11Clinical Trial Update: A Study of BMN 255 in Participants With Non-Alcoholic Fatty Liver Disease And Hyperoxaluria [Phase 1]
BioMarin's BMN-255 Phase 1 trial in hyperoxaluria with nonalcoholic fatty liver disease has been withdrawn.
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CLINICAL_TRIALS trial_result · 2023-10-23Clinical Trial Update: Dapagliflozin and Hydrochlorothiazide in Recurring Kidney Stone Patients [Phase 4]
Phase 4 trial update on dapagliflozin and hydrochlorothiazide in patients with recurring kidney stones (urolithiasis) and hyperoxaluria; sta…
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FDA approval · 2023-09-29FDA Approved: RIVFLOZA — Original Application (Novo Nordisk)
The FDA approved Rivfloza (nedosiran) from Novo Nordisk through an Original Application (NDA215842) for the treatment of primary hyperoxalur…
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CLINICAL_TRIALS trial_result · 2022-07-12Clinical Trial Update: A Study to Evaluate Lumasiran in Patients With Advanced Primary Hyperoxaluria Type 1 [Phase 3]
A Phase 3 study evaluating Lumasiran for advanced Primary Hyperoxaluria Type 1 has completed and posted results.
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CLINICAL_TRIALS trial_result · 2021-12-09Clinical Trial Update: A Study to Evaluate the Efficacy and Safety of Oxabact in Patients With Primary Hyperoxaluria [Phase 3]
Phase 3 trial evaluating Oxabact for primary hyperoxaluria has completed; results posted in 2021.
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CLINICAL_TRIALS trial_result · 2021-12-09Clinical Trial Update: Study to Evaluate the Efficacy and Safety of Oxabact (OC5) in Primary Hyperoxaluria Patients Who Are on Dialysis [Phase 2]
A Phase 2 trial evaluating Oxabact (OC5) for efficacy and safety in patients with primary hyperoxaluria on dialysis has completed, with resu…
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CLINICAL_TRIALS trial_result · 2021-12-08Clinical Trial Update: An Extension Study to Evaluate the Long-term Efficacy and Safety of Oxabact in Patients With Primary Hyperoxaluria [Phase 3]
An extension study of Oxabact in primary hyperoxaluria (Phase 3) has been terminated; results posted in 2021. Long-term efficacy and safety …
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CLINICAL_TRIALS trial_result · 2021-03-26Clinical Trial Update: Evaluation of the Efficacy of Stiripentol (Diacomit) as Monotherapy for the Treatment of Primary Hyperoxaluria [Phase 2]
Phase 2 clinical trial evaluating stiripentol (Diacomit) as monotherapy for primary hyperoxaluria has completed.
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CLINICAL_TRIALS trial_result · 2021-01-08Clinical Trial Update: Lanthanum Carbonate (Fosrenol®) to Reduce Oxalate Excretion in Patients With Secondary Hyperoxaluria and Nephrolithiasis [Phase 3]
Phase 3 trial investigating lanthanum carbonate (Fosrenol) to reduce oxalate excretion in patients with secondary hyperoxaluria and nephroli…
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CLINICAL_TRIALS trial_result · 2020-12-30Clinical Trial Update: Study of ALLN-177 in Patients Aged 12 Years or Older With Enteric or Primary Hyperoxaluria and Hyperoxalemia [Phase 2]
Phase 2 trial update for ALLN-177 in patients aged 12 and older with enteric or primary hyperoxaluria and hyperoxalemia has completed.
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CLINICAL_TRIALS trial_result · 2020-03-24Clinical Trial Update: A Pilot Study of Oxalate Absorption in Secondary Hyperoxaluria [NA]
A completed pilot trial evaluating oxalate absorption in secondary hyperoxaluria; results posted.
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CLINICAL_TRIALS trial_result · 2018-01-11Clinical Trial Update: Evaluate the Effect of ALLN-177 in Reducing Urinary Oxalate in Patients With Hyperoxaluria and Kidney Stones [Phase 2]
Phase 2 trial evaluating ALLN-177 for reducing urinary oxalate in patients with hyperoxaluria and kidney stones has completed.
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CLINICAL_TRIALS trial_result · 2017-07-02Clinical Trial Update: Hydroxyproline Influence on Oxalate Metabolism [Phase 1, Phase 2]
Phase 1 and Phase 2 trials evaluated the effect of hydroxyproline on oxalate metabolism in hyperoxaluria. Results were posted after completi…
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CLINICAL_TRIALS trial_result · 2017-01-19Clinical Trial Update: Evaluate the Effect of ALLN-177 in Reducing Urinary Oxalate in Patients With Secondary Hyperoxaluria and Kidney Stones Over 28 Days [Phase 2]
Phase 2 trial evaluating ALLN-177 for reducing urinary oxalate in patients with secondary hyperoxaluria and nephrolithiasis over 28 days; th…
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CLINICAL_TRIALS withdrawal · 2017-01-05Clinical Trial Update: A Trial of Pyridoxamine to Lower Urine Oxalate in Subjects With Stone Disease or Hyperoxaluria [Phase 2]
A Phase 2 trial investigating pyridoxamine to reduce urine oxalate in people with nephrolithiasis or hyperoxaluria has been withdrawn.
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CLINICAL_TRIALS trial_result · 2016-10-27Clinical Trial Update: Effect of Over-the-counter Dietary Supplements on Kidney Stone Risk [NA]
A completed clinical trial investigated the effect of over-the-counter dietary supplements on kidney stone risk in individuals with hyperoxa…