Plexiform Neurofibroma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2026-03-12Clinical Trial Update: Study of Cabozantinib With Selumetinib for Plexiform Neurofibromas [Phase 1]
A Phase 1 clinical trial is evaluating the combination of cabozantinib and selumetinib for plexiform neurofibromas in Neurofibromatosis type…
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CLINICAL_TRIALS trial_result · 2025-10-20Clinical Trial Update: Efficacy and Safety of Selumetinib in Adults With NF1 Who Have Symptomatic, Inoperable Plexiform Neurofibromas [Phase 3]
Phase 3 clinical trial results evaluate the efficacy and safety of selumetinib in adults with neurofibromatosis type 1 and symptomatic, inop…
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CLINICAL_TRIALS trial_result · 2025-08-07Clinical Trial Update: MEK Inhibitor Mirdametinib (PD-0325901) in Patients With Neurofibromatosis Type 1 Associated Plexiform Neurofibromas [Phase 2]
Phase 2 clinical trial of the MEK inhibitor mirdametinib for Neurofibromatosis type 1–associated plexiform neurofibromas has posted results.
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CLINICAL_TRIALS trial_result · 2025-07-24Clinical Trial Update: Targeting the Mechanisms Underlying Cutaneous Neurofibroma Formation in NF1: A Clinical Translational Approach.
A completed clinical trial update exploring the mechanisms behind cutaneous neurofibroma formation in neurofibromatosis type 1 using a trans…
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CLINICAL_TRIALS trial_result · 2025-05-14Clinical Trial Update: Pharmacokinetics, Safety and Efficacy of the Selumetinib Granule Formulation in Children Aged ≥1 to <7 Years With NF1-related Symptomatic, Inoperable PN [Phase 1, Phase 2]
Phase 1/2 trial evaluating pharmacokinetics, safety, and efficacy of a granule formulation of selumetinib in children with Neurofibromatosis…
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CLINICAL_TRIALS trial_result · 2025-05-02Clinical Trial Update: Phase II Study of Binimetinib in Children and Adults With NF1 Plexiform Neurofibromas [Phase 2]
Phase II trial of binimetinib in children and adults with NF1-associated plexiform neurofibromas has completed. Results have been posted.
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CLINICAL_TRIALS trial_result · 2024-06-11Clinical Trial Update: Medication Adherence in Children, Adolescents and Adults With Neurofibromatosis Type 1(NF1) on Clinical Treatment Trials [NA]
This clinical trial update reports that the medication adherence study in people with Neurofibromatosis type 1 across children, adolescents,…
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CLINICAL_TRIALS trial_result · 2024-04-04Clinical Trial Update: Intermittent Dosing Of Selumetinib In Childhood NF1 Associated Tumours [Phase 1, Phase 2]
Phase 1/2 trial data on intermittent dosing of selumetinib in children with Neurofibromatosis Type 1-related tumours, including plexiform ne…
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CLINICAL_TRIALS trial_result · 2019-01-10Clinical Trial Update: MEK Inhibitor PD-0325901 Trial in Adolescents and Adults With NF1 [Phase 2]
Phase 2 trial of MEK inhibitor PD-0325901 in adolescents and adults with Neurofibromatosis Type 1 and growing or symptomatic, inoperable ple…
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CLINICAL_TRIALS trial_result · 2018-08-08Clinical Trial Update: Combination Chemotherapy in Treating Patients With Neurofibromatosis and Progressive Plexiform Neurofibromas [Phase 2]
Phase 2 trial evaluating combination chemotherapy for neurofibromatosis type 1 with progressive plexiform neurofibromas has completed with r…
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CLINICAL_TRIALS trial_result · 2017-11-06Clinical Trial Update: Study of PEG-Intron for Plexiform Neurofibromas [Phase 2]
A Phase 2 study of PEG-Intron for Plexiform Neurofibromas has completed enrollment with results posted in 2017.
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CLINICAL_TRIALS trial_result · 2017-07-02Clinical Trial Update: Pilot Study of Gleevec/Imatinib Mesylate (STI-571, NSC 716051) in Neurofibromatosis (NF1) Patient With Plexiform Neurofibromas [Phase 1, Phase 2]
A Phase 1/2 pilot study evaluated imatinib mesylate (Gleevec) in patients with neurofibromatosis type 1 and plexiform neurofibromas; the tri…
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CLINICAL_TRIALS trial_result · 2017-04-12Clinical Trial Update: Study of Tasigna®/Nilotinib (AMN107) in Neurofibromatosis (NF1) Patients With Plexiform Neurofibromas [EARLY_Phase 1]
This update reports an early-phase 1 trial of nilotinib (Tasigna) in patients with Neurofibromatosis type 1 and plexiform neurofibromas, wit…
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CLINICAL_TRIALS trial_result · 2016-05-12Clinical Trial Update: Efficacy and Safety of RAD001 in Treating Plexiform Neurofibromas (PN) Associated With Neurofibromatosis (NF1) [Phase 2]
Phase 2 trial evaluating RAD001 (everolimus) for plexiform neurofibromas in Neurofibromatosis Type 1 was terminated, with results posted in …
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CLINICAL_TRIALS trial_result · 2016-05-04Clinical Trial Update: Study of Sutent®/Sunitinib (SU11248) in Subjects With NF-1 Plexiform Neurofibromas [Phase 2]
Phase 2 trial of sunitinib (Sutent) in neurofibromatosis type 1 with plexiform neurofibromas was terminated; results were posted on 2016-05-…
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CLINICAL_TRIALS trial_result · 2016-04-06Clinical Trial Update: Phase II Study of Gleevec/Imatinib Mesylate (STI-571, NCS 716051) in Neurofibromatosis (NF1) Patients With Plexiform Neurofibromas [Phase 2]
Phase II study assessing imatinib (Gleevec) in neurofibromatosis type 1 patients with plexiform neurofibromas has completed, with results po…
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CLINICAL_TRIALS trial_result · 2015-04-30Clinical Trial Update: Pirfenidone in Treating Young Patients With Neurofibromatosis Type 1 and Plexiform Neurofibromas [Phase 1]
Phase 1 clinical trial evaluating pirfenidone in young patients with Neurofibromatosis Type 1 and plexiform neurofibromas has completed.
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CLINICAL_TRIALS trial_result · 2015-04-15Clinical Trial Update: Phase I Clinical Study of the Safety of Photodynamic Therapy (PDT) Using LS11 in Children With Plexiform Neurofibromas [Phase 1]
Phase I safety study of photodynamic therapy using LS11 in children with plexiform neurofibromas, sponsored by Children's Hospital of Philad…
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CLINICAL_TRIALS trial_result · 2014-11-14Clinical Trial Update: Use of RAD001 as Monotherapy in the Treatment of Neurofibromatosis 1 Related Internal Plexiform Neurofibromas [Phase 2]
A Phase 2 trial of RAD001 (everolimus) as monotherapy for Neurofibromatosis type 1-related internal plexiform neurofibromas has completed.
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CLINICAL_TRIALS trial_result · 2014-04-04Clinical Trial Update: Fludeoxyglucose F 18 Positron Emission Tomography and Magnetic Resonance Perfusion Imaging in Patients With Neurofibromatosis 1 and Plexiform Neurofibroma [NA]
A terminated clinical trial evaluated FDG-PET and MR perfusion imaging in patients with Neurofibromatosis Type 1 and plexiform neurofibromas…
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CLINICAL_TRIALS trial_result · 2013-09-26Clinical Trial Update: AZD2171 in Treating Patients With Neurofibromatosis Type 1 and Plexiform Neurofibroma and/or Neurofibroma Near the Spine [Phase 2]
AZD2171 (cediranib) was studied in Neurofibromatosis Type 1–associated neurofibromas, including plexiform neurofibromas and spinal cord neur…
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CLINICAL_TRIALS trial_result · 2012-09-17Clinical Trial Update: R115777 to Treat Children With Neurofibromatosis Type 1 and Progressive Plexiform Neurofibromas [Phase 2]
Phase 2 clinical trial of tipifarnib (R115777) in children with Neurofibromatosis Type I and progressive plexiform neurofibromas completed; …
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CLINICAL_TRIALS trial_result · 2012-07-12Clinical Trial Update: Pirfenidone in Children and Young Adults With Neurofibromatosis Type I and Progressive Plexiform Neurofibromas [Phase 2]
Phase 2 trial of pirfenidone in children and young adults with Neurofibromatosis type I and progressive plexiform neurofibromas has complete…
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CLINICAL_TRIALS trial_result · 2012-03-29Clinical Trial Update: PEG-Interferon Alfa-2b in Treating Young Patients With Plexiform Neurofibroma [Phase 1]
A Phase 1 trial evaluating pegylated interferon alfa-2b in young patients with plexiform neurofibroma has completed.