Patent Ductus Arteriosus
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2019-07-08Clinical Trial Update: Early Ibuprofen Treatment of Patent Ductus Arteriosus (PDA) in Premature Infants (TRIOCAPI) [Phase 3]
Phase 3 trial update on early ibuprofen treatment for patent ductus arteriosus in premature infants (TRIOCAPI) completed.
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CLINICAL_TRIALS withdrawal · 2019-02-04Clinical Trial Update: Emergency/Compassionate Use - AMPLATZER Duct Occluder
This clinical trial update notes that the emergency/compassionate use program for the AMPLATZER Duct Occluder has become no longer available…
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CLINICAL_TRIALS trial_result · 2018-11-30Clinical Trial Update: Early Treatment Versus Delayed Conservative Treatment of the Patent Ductus Arteriosus [Phase 2]
Phase 2 trial comparing early treatment versus delayed conservative management for patent ductus arteriosus; results posted after completion…
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CLINICAL_TRIALS research · 2018-07-30Clinical Trial Update: Alternative Paracetamol Treatments for the Neonate With a hsPDA [Phase 2, Phase 3]
Phase 2 and Phase 3 clinical trials are evaluating alternative paracetamol treatments to close hemodynamically significant patent ductus art…
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CLINICAL_TRIALS trial_result · 2018-05-07Clinical Trial Update: The Use of B-type Natriuretic Peptide (BNP) to Predict Closure of a Patent Ductus Arteriosus (PDA) in Premature Infants [NA]
This update reports a completed trial investigating whether B-type natriuretic peptide can predict the closure of patent ductus arteriosus i…
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CLINICAL_TRIALS trial_result · 2018-04-06Clinical Trial Update: Platelet Transfusion for Treatment of Patent Ductus Arteriosus in Thrombocytopenic Preterm Neonates [Phase 3]
A Phase 3 trial evaluating platelet transfusion as a treatment for patent ductus arteriosus in thrombocytopenic preterm neonates has complet…
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CLINICAL_TRIALS trial_result · 2018-03-23Clinical Trial Update: NIT-OCCLUD PDA Phase II Sentinel Trial [NA]
A Phase II sentinel trial evaluating the NIT-OCCLUD PDA device for closing patent ductus arteriosus has completed.
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CLINICAL_TRIALS research · 2017-08-29Clinical Trial Update: Paracetamol Versus Ibuprofen for PDA Closure [Phase 4]
A Phase 4 clinical trial update comparing paracetamol and ibuprofen for closure of patent ductus arteriosus, with the current status not dis…
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CLINICAL_TRIALS research · 2017-07-25Clinical Trial Update: Laser Acupuncture and Pain Management in Preterm Infants Undergoing Patent Ductus Arteriosus Ligation [NA]
This clinical trial update reports on a completed study evaluating laser acupuncture for pain management in preterm infants undergoing paten…
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FDA approval · 2017-06-22FDA Approved: INDOMETHACIN — Original Application (Glenmark Pharmaceuticals Inc., USA)
FDA approved Glenmark's Indomethacin generic under an Original Application; this entry records the approval status and product details.
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CLINICAL_TRIALS trial_result · 2017-04-13Clinical Trial Update: Increase of Prostaglandin E2 in Reversal of Ductal Constriction After Dietary Restriction of Polyphenols [NA]
This clinical trial update notes the completion of a study investigating whether dietary restriction of polyphenols increases prostaglandin …
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CLINICAL_TRIALS research · 2017-02-10Clinical Trial Update: NIRS in PDA VLBW Infants
This clinical trial update reports the completion of a study evaluating near-infrared spectroscopy (NIRS) in very low birth weight infants w…
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CLINICAL_TRIALS research · 2016-09-22Clinical Trial Update: International Experience in Timing And Choices for Ductal Closure in Patent Ductus Arteriosus:INTERPDA Trial
An international update on the INTERPDA trial examining timing and choices for closing the patent ductus arteriosus.
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CLINICAL_TRIALS trial_result · 2016-09-09Clinical Trial Update: A New Device for Measuring of Lung Photoplethysmography and Pulmonic Arterial Saturation
A clinical trial update describing a new device to measure lung photoplethysmography and pulmonic arterial saturation, in the context of Pat…
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CLINICAL_TRIALS trial_result · 2016-09-07Clinical Trial Update: Plethismographic Perfusion Index in Neonates
Clinical trial update on Plethismographic Perfusion Index in neonates, involving patent ductus arteriosus and persistent pulmonary hypertens…
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CLINICAL_TRIALS trial_result · 2016-08-18Clinical Trial Update: An Escalating Dose Indomethacin for the Treatment of Persistent Patent Ductus Arteriosus (PDA) In Preterm Infants [Phase 2, Phase 3]
The document describes escalating-dose indomethacin trials for treating persistent patent ductus arteriosus in preterm infants, across Phase…
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CLINICAL_TRIALS trial_result · 2016-07-06Clinical Trial Update: Paracetamol Treatment of the Borderline Significant PDA [Phase 2]
An update on a Phase 2 clinical trial evaluating paracetamol for the treatment of patent ductus arteriosus.
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CLINICAL_TRIALS trial_result · 2016-07-04Clinical Trial Update: Early Versus Late Use of Ibuprofen for Patent Ductus Arteriosus (PDA) Closure [NA]
This clinical trial update reports the results of a terminated study comparing early versus late use of ibuprofen to close patent ductus art…
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FDA approval · 2016-05-09FDA Approved: INDOMETHACIN — Supplemental Application (Amneal Pharmaceuticals LLC)
FDA approves Amneal's supplemental application for INDOMETHACIN, marking an approved modification to the product under an ANDA.
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FDA approval · 2016-05-09FDA Approved: INDOMETHACIN — Supplemental Application (Camber Pharmaceuticals, Inc.)
FDA approved Camber Pharmaceuticals' supplemental application for Indomethacin, resulting in updated labeling for the product.
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CLINICAL_TRIALS trial_result · 2016-04-26Clinical Trial Update: The Impact of Platelet Functions on Spontaneous Ductal Closure in Preterm Infants
A completed Ankara University–sponsored study examined how platelet function relates to spontaneous closure of the ductus arteriosus in pret…
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CLINICAL_TRIALS trial_result · 2016-04-06Clinical Trial Update: Influence of Treatment for Patent Ductus Arteriosus on Cerebral Oxygenation in Preterm Infants
A completed clinical trial evaluated how treatment of patent ductus arteriosus influences cerebral oxygenation in preterm infants.
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CLINICAL_TRIALS trial_result · 2016-02-18Clinical Trial Update: Reproduction and Survival After Cardiac Defect Repair
The NHLBI-sponsored clinical trial reports on reproduction and survival outcomes after repair of congenital heart defects; the study has com…
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CLINICAL_TRIALS research · 2015-11-17Clinical Trial Update: The Best Treatment Strategy: Surgical vs Pharmacological to Close the Ductus Arteriosus Persistent in Preterm Infants [Phase 2]
This clinical trial update discusses evaluating the best treatment strategy to close the patent ductus arteriosus in preterm infants, compar…
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CLINICAL_TRIALS trial_result · 2015-09-02Clinical Trial Update: Safety of Fluconazole Treatment of Premature and Full-term Newborn Infants [Phase 4]
Phase 4 safety update evaluating fluconazole treatment in premature and full-term newborn infants.