Opioid-induced Constipation
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2017-08-30Clinical Trial Update: Effect of Naloxegol on Gastric, Small Bowel, and Colonic Transit in Healthy Subjects [Phase 1]
A Phase 1 study in healthy subjects evaluated the effects of naloxegol on gastric, small bowel, and colonic transit to characterize its impa…
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FDA approval · 2017-08-01FDA Approved: RELISTOR — Supplemental Application (Salix Pharmaceuticals, Inc.)
The FDA approved a supplemental application for Relistor (methylnaltrexone bromide) from Salix Pharmaceuticals, Inc.
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FDA approval · 2017-08-01FDA Approved: SYMPROIC — Supplemental Application (BioDelivery Sciences International Inc)
FDA approved a supplemental application for Symproic (naldemedine) from BioDelivery Sciences International Inc.
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FDA approval · 2017-08-01FDA Approved: MOVANTIK — Supplemental Application (RedHill Biopharma Ltd)
The FDA approved a supplemental application for Movantik (naloxegol oxalate) submitted by RedHill Biopharma Ltd.
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CLINICAL_TRIALS trial_result · 2017-05-30Clinical Trial Update: Efficacy and Safety of Naldemedine in the Treatment of Opioid-induced Constipation [Phase 3]
Phase 3 trial results evaluate the efficacy and safety of naldemedine for opioid-induced constipation. The trial was conducted by Shionogi a…
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CLINICAL_TRIALS trial_result · 2017-05-30Clinical Trial Update: Efficacy and Safety of Naldemedine in Treating Opioid-induced Constipation [Phase 3]
A Phase 3 clinical trial update reports on the efficacy and safety of naldemedine for treating opioid-induced constipation.
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CLINICAL_TRIALS trial_result · 2017-05-30Clinical Trial Update: A Study of Naldemedine (S-297995) for the Treatment of Opioid-Induced Constipation in Adults With Non-Malignant Chronic Pain Receiving Opioid Therapy [Phase 2]
Phase 2 trial results for Naldemedine (S-297995) in adults with opioid-induced constipation due to non-malignant chronic pain on opioid ther…
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CLINICAL_TRIALS trial_result · 2017-05-30Clinical Trial Update: Long Term Safety of Naldemedine [Phase 3]
Phase 3 long-term safety results for naldemedine in opioid-induced constipation were reported.
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FDA approval · 2017-05-16FDA Approved: RELISTOR — Supplemental Application (Salix Pharmaceuticals, Inc.)
The FDA approved a supplemental application for RELISTOR (methylnaltrexone bromide) from Salix Pharmaceuticals, expanding its labeling relat…
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FDA approval · 2017-05-16FDA Approved: RELISTOR — Supplemental Application (Salix Pharmaceuticals, Inc.)
FDA approved a supplemental application for Relistor (methylnaltrexone bromide) by Salix Pharmaceuticals, expanding its labeling for opioid-…
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FDA approval · 2017-03-23FDA Approved: SYMPROIC — Original Application (BioDelivery Sciences International Inc)
The FDA approved Symproic (naldemedine) from BioDelivery Sciences International, granting original NDA approval NDA208854 for the treatment …
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FDA approval · 2016-10-11FDA Approved: LUBIPROSTONE — Supplemental Application (Dr. Reddy's Laboratories Inc.)
FDA approved a supplemental application for Lubiprostone from Dr. Reddy's Laboratories Inc., typically reflecting updates to labeling or ind…
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FDA approval · 2016-08-22FDA Approved: MOVANTIK — Supplemental Application (RedHill Biopharma Ltd)
FDA approved a supplemental application for Movantik (naloxegol oxalate) from RedHill Biopharma Ltd.
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FDA approval · 2016-07-22FDA Approved: MOVANTIK — Supplemental Application (RedHill Biopharma Ltd)
The FDA approved a supplemental application for MOVANTIK (naloxegol oxalate) from RedHill Biopharma Ltd, potentially expanding or updating t…
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FDA approval · 2016-07-19FDA Approved: RELISTOR — Original Application (Salix Pharmaceuticals, Inc.)
FDA approved Relistor (methylnaltrexone bromide) as an original NDA submission by Salix Pharmaceuticals, marking its regulatory clearance fo…
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CLINICAL_TRIALS trial_result · 2016-05-04Clinical Trial Update: A Single-arm, Study to Assess the Effect and Tolerability of Standardised Laxative Therapy (SLT) for the Reversal of Opioid-induced Constipation (OIC). [Phase 4]
Phase 4, single-arm trial completed to assess the effect and tolerability of Standardised Laxative Therapy (SLT) for reversing opioid-induce…
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CLINICAL_TRIALS other · 2015-10-14Clinical Trial Update: Study of Methylnaltrexone in Opioid-Induced Constipation Patients [Phase 2, Phase 3]
A Phase 2/3 clinical trial evaluating methylnaltrexone for opioid-induced constipation is being conducted by Chia Tai Tianqing Pharmaceutica…
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CLINICAL_TRIALS trial_result · 2015-10-12Clinical Trial Update: Opioid Induced Bowel Dysfunction in Patients Undergoing Spinal Surgery [Phase 4]
This clinical trial update notes the completion of a Phase 4 study evaluating opioid-induced bowel dysfunction, focusing on constipation, in…
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CLINICAL_TRIALS trial_result · 2015-09-28Clinical Trial Update: Safety Study of CB-5945 for the Treatment of Opioid-Induced Constipation [Phase 3]
Phase 3 safety study of CB-5945 for opioid-induced constipation has been terminated with results posted in 2015.
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CLINICAL_TRIALS trial_result · 2015-09-02Clinical Trial Update: Alvimopan For The Treatment Of Constipation Due To Opioids Being Taken For Persistent Non-Cancer Pain [Phase 3]
Phase 3 trial update of alvimopan (Entereg) for opioid-induced constipation in patients with persistent non-cancer pain; the study has compl…
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CLINICAL_TRIALS trial_result · 2015-09-02Clinical Trial Update: Treatment Of Constipation Due To Opioids Being Taken For Persistent Non-Cancer Pain [Phase 3]
Phase 3 clinical trial evaluating treatment for opioid-induced constipation in adults with persistent non-cancer pain has completed.
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CLINICAL_TRIALS trial_result · 2015-08-07Clinical Trial Update: Non-interventional Study Comparing Targiniq and Oxycodone/Laxatives
A completed non-interventional study comparing Targiniq (oxycodone/naloxone) to oxycodone plus laxatives in patients with pain and opioid-in…
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CLINICAL_TRIALS trial_result · 2015-07-29Clinical Trial Update: Enteral Naloxone Versus a Traditional Bowel Regimen for the Prevention of Opioid Induced Constipation in Trauma Patients [Phase 4]
Phase 4 trial comparing enteral naloxone to a traditional bowel regimen to prevent opioid-induced constipation in trauma patients; the study…
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CLINICAL_TRIALS research · 2015-07-08Clinical Trial Update: Longitudinal Study of Patients With Opioid-Induced Constipation
A longitudinal clinical trial on patients with opioid-induced constipation sponsored by AstraZeneca has completed.
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CLINICAL_TRIALS trial_result · 2015-07-02Clinical Trial Update: Efficacy and Safety Study of CB-5945 for the Treatment of Opioid-Induced Constipation [Phase 3]
Phase 3 study of CB-5945 for opioid-induced constipation has terminated; results posted in 2015.