Non-small Cell Lung Cancer
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS withdrawal · 2024-12-09Clinical Trial Update: Vactosertib in Combination with Pembrolizumab for PD-L1 Positive Non-small Cell Lung Cancer (NSCLC) Subjects [Phase 2]
Phase 2 trial of Vactosertib in combination with Pembrolizumab for PD-L1 positive non-small cell lung cancer has been terminated.
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CLINICAL_TRIALS withdrawal · 2024-12-09Clinical Trial Update: Stereotactic Body Radiotherapy for Lung Lesions With Markerless Tracking (MLT) on the VERO® SBRT System
The clinical trial evaluating markerless tracking SBRT for lung lesions on the VERO system has been withdrawn.
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CLINICAL_TRIALS research · 2024-12-06Clinical Trial Update: Using ctDNA to Detect Minimal Residual Disease After Lung Cancer Resection
A clinical trial is evaluating whether circulating tumor DNA can detect minimal residual disease after surgical resection of non-small cell …
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CLINICAL_TRIALS research · 2024-12-06Clinical Trial Update: The Efficacy and Safety of Adjuvant Immunotherapy After Pathological Complete Response Following Neoadjuvant Chemoimmunotherapy in Patients with Resectable NSCLC
This clinical trial update discusses the efficacy and safety of adjuvant immunotherapy after pathological complete response following neoadj…
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CLINICAL_TRIALS withdrawal · 2024-12-06Clinical Trial Update: Neoadjuvant JS001, or JS001 in Combination With Pemetrexed and Carboplatin in Resectable NSCLC. [Phase 2]
A Phase 2 neoadjuvant trial of JS001 alone or in combination with pemetrexed and carboplatin for resectable non-small cell lung cancer has b…
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CLINICAL_TRIALS trial_result · 2024-12-06Clinical Trial Update: Evaluation ctDNA in Patients of Non-Small-Cell Lung Cancer Following Resection
A completed clinical study evaluating circulating tumor DNA (ctDNA) in patients with Non-Small Cell Lung Cancer following surgical resection…
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CLINICAL_TRIALS research · 2024-12-06Clinical Trial Update: Korean Registry of Non-Small Cell Lung Cancer Patients with EGFR Mutation
This clinical trial registry entry notes that a Korean registry of non-small cell lung cancer patients with EGFR mutations is active but not…
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CLINICAL_TRIALS trial_result · 2024-12-05Clinical Trial Update: A Trial of Sintilimab Plus Anlotinib For Metastatic NSCLC After First-Line PD-1 Inhibitor [Phase 2]
Phase 2 trial evaluating the combination of sintilimab and anlotinib in metastatic non-small cell lung cancer after a prior PD-1 inhibitor h…
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CLINICAL_TRIALS trial_result · 2024-12-05Clinical Trial Update: Real World Evidence of Long-term Safety and Efficacy in Patients Treated With Durvalumab After Concurrent Chemoradiation for Unresectable Stage III NSCLC
Real-world evidence evaluating long-term safety and efficacy of durvalumab after concurrent chemoradiation in patients with unresectable sta…
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CLINICAL_TRIALS research · 2024-12-05Clinical Trial Update: A Study to Investigate the Efficacy and Safety of an Infusion of IOV-4001 in Adult Participants With Unresectable or Metastatic Melanoma or Stage III or IV Non-small-cell Lung Cancer [Phase 1, Phase 2]
Phase 1/2 trial evaluating IOV-4001 for unresectable or metastatic melanoma and stage III/IV non-small cell lung cancer is currently recruit…
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CLINICAL_TRIALS trial_result · 2024-12-05Clinical Trial Update: Concomitant Radiotherapy, Tremelimumab & Durvalumab for Advanced NSCLC Patients Progressing on First-line Immunotherapy [Phase 2]
A Phase 2 clinical trial is evaluating the combination of tremelimumab and durvalumab with concomitant radiotherapy in advanced non-small ce…
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CLINICAL_TRIALS research · 2024-12-05Clinical Trial Update: Chemotherapy Plus Immunotherapy Combined With SBRT as Neoadjuvant Therapy for Patients With Resectable NSCLC [Phase 2]
A Phase 2 trial evaluating chemotherapy plus immunotherapy with SBRT as neoadjuvant therapy for resectable non-small cell lung cancer; the s…
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CLINICAL_TRIALS trial_result · 2024-12-04Clinical Trial Update: A Single Arm Phase 2 Study to Evaluate Efficacy and Safety of Trastuzumab Deruxtecan for Patients With HER2 Mutant NSCLC [Phase 2]
A single-arm Phase 2 trial evaluating the efficacy and safety of trastuzumab deruxtecan in patients with HER2-mutant non-small cell lung can…
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CLINICAL_TRIALS trial_result · 2024-12-04Clinical Trial Update: Neo-Adjuvant Immunotherapy With Nivolumab for Non Small Cell Lung Cancer Patients [Phase 2]
This update reports results from a Phase 2 trial of nivolumab as neo-adjuvant immunotherapy in non-small cell lung cancer.
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CLINICAL_TRIALS research · 2024-12-04Clinical Trial Update: PET Imaging of Cancer Patients Using 68Ga-DOTA-Siglec-9
A clinical trial is evaluating the PET imaging tracer 68Ga-DOTA-Siglec-9 in cancer patients. The study is currently enrolling by invitation …
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CLINICAL_TRIALS research · 2024-12-04Clinical Trial Update: Neo-Bio-ADAURA: a Phase II Study to Evaluate Mechanisms of Resistance to Neoadjuvant Osimertinib [Phase 2]
This document provides an update on a Phase II trial (Neo-Bio-ADAURA) evaluating mechanisms of resistance to neoadjuvant osimertinib in non-…
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CLINICAL_TRIALS research · 2024-12-04Clinical Trial Update: Endobronchial Ultrasound-guided Transbronchial Needle Aspiration for Lymph Node Staging in Patients With Non-small Cell Lung Cancer Pursuing Stereotactic Body Radiotherapy (SBRT) [NA]
This clinical trial update describes using endobronchial ultrasound-guided transbronchial needle aspiration (EBUS-TBNA) to stage lymph nodes…
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CLINICAL_TRIALS research · 2024-12-04Clinical Trial Update: Tumor Treating Fields (TTF) in Combination with Stereotactic Radiosurgery(SRS) for Brain Metastases from Non-small Cell Lung Cancer. [NA]
The document reports a clinical trial evaluating tumor treating fields in combination with stereotactic radiosurgery for brain metastases fr…
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EMA approval · 2024-12-03EMA Authorised: Lumykras (sotorasib) — Amgen Europe B.V.
The EMA authorised Lumykras (sotorasib) for non-small-cell lung cancer. The decision includes a conditional approval.
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CLINICAL_TRIALS trial_result · 2024-12-03Clinical Trial Update: The Selective Personalized Radio-Immunotherapy for Locally Advanced NSCLC Trial [Phase 2]
A Phase 2 trial update reports completion and results posting for the selective personalized radio-immunotherapy approach in locally advance…
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CLINICAL_TRIALS research · 2024-12-02Clinical Trial Update: Exploring the Mechanism of Primary Resistance to Third-generation EGFR-TKIs as First-line Treatment in EGFR-positive Advanced NSCLC (PRECISE Study)
This study investigates mechanisms of primary resistance to first-line third-generation EGFR-TKIs in EGFR-mutant advanced non-small cell lun…
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CLINICAL_TRIALS research · 2024-11-29Clinical Trial Update: Analysis of RATS, VATS and Open Lung Resections After Neoadjuvant Chemo-immunotherapy in Patients Performed in Five Referred Centers
A multi-center study evaluating robotic-assisted (RATS), video-assisted (VATS), and open lung resections following neoadjuvant chemo-immunot…
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CLINICAL_TRIALS research · 2024-11-29Clinical Trial Update: A Multicountry, Multicentre, Non-interventional, Retrospective Study to Determine Real-world Treatment Patterns and Associated Outcomes After First Line Osimertinib in Patients With Advanced and Metastatic NSCLC EGFRm in the GCC Region
A completed non-interventional retrospective study conducted across multiple countries aims to characterize real-world treatment patterns an…
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CLINICAL_TRIALS research · 2024-11-29Clinical Trial Update: Immuno-pet IMaging ResPonses AdministeRed Immune CheckpoiNt InhibiTor [Phase 2, Phase 3]
A Phase 2/Phase 3 clinical trial from Radboud University Medical Center is evaluating immuno-PET imaging to assess responses to an immune ch…
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CLINICAL_TRIALS research · 2024-11-29Clinical Trial Update: Minimal Residual Disease Guiding Adjuvant Therapy in Stage I NSCLC [NA]
This clinical trial update describes a study evaluating whether minimal residual disease can guide adjuvant therapy in stage I non-small cel…