Non-small Cell Lung Cancer
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CLINICAL_TRIALS research · 2025-01-20Clinical Trial Update: Artificial Intelligence-based Model for the Prediction of Occult Lymph Node Metastasis and Improvement of Clinical Decision-making in Non-small Cell Lung Cancer
This clinical trial update describes an artificial intelligence-based model to predict occult lymph node metastasis in non-small cell lung c…
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EMA withdrawal · 2025-01-17EMA Withdrawn: Gavreto (pralsetinib) — Blueprint Medicines (Netherlands) B.V.
The EMA has withdrawn Gavreto (pralsetinib) from its marketing authorization; the decision was made on 17 July 2024 and relates to a previou…
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CLINICAL_TRIALS approval · 2025-01-17Clinical Trial Update: Expanded Access for the Treatment of Cancers With Rearranged During Transfection (RET) Activation
Eli Lilly's RET inhibitor selpercatinib (Retevmo) has been approved for marketing to treat cancers driven by RET activation, including non-s…
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CLINICAL_TRIALS trial_result · 2025-01-17Clinical Trial Update: A Study of ELI-002 in Subjects With KRAS Mutated Pancreatic Ductal Adenocarcinoma (PDAC) and Other Solid Tumors [Phase 1]
Phase 1 study of ELI-002 in KRAS-mutated pancreatic ductal adenocarcinoma and other KRAS-driven solid tumors has completed enrollment, with …
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CLINICAL_TRIALS research · 2025-01-17Clinical Trial Update: Neoadjuvant Nivolumab with CCR2/5-inhibitor or Anti-IL-8) for Non-small Cell Lung Cancer (NSCLC) or Hepatocellular Carcinoma (HCC) [Phase 2]
Phase 2 neoadjuvant trial evaluating nivolumab with a CCR2/5 inhibitor or anti-IL-8 in non-small cell lung cancer and hepatocellular carcino…
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CLINICAL_TRIALS research · 2025-01-17Clinical Trial Update: Adjuvant Treatment of ALK-positive Non-small Cell Lung Cancer with Ensartinib Guided by MRD [Phase 2]
Phase 2 clinical trial update evaluating adjuvant treatment of ALK-positive non-small cell lung cancer with ensartinib guided by MRD (minima…
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CLINICAL_TRIALS research · 2025-01-17Clinical Trial Update: Neoadjuvant Ensartinib in ALK Positive Resectable Stage II to III Non-Small Cell Lung Cancer [Phase 2]
A Phase 2 neoadjuvant trial of ensartinib for ALK-positive resectable stage II to III non-small cell lung cancer is currently not yet recrui…
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CLINICAL_TRIALS research · 2025-01-16Clinical Trial Update: LcProt: Proteomics Longitudinal Cohort Study on Lung Cancer
Update on the LcProt proteomics longitudinal cohort study investigating lung cancer; recruitment is ongoing.
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CLINICAL_TRIALS trial_result · 2025-01-15Clinical Trial Update: CAB-ROR2-ADC Safety and Efficacy Study in Patients With TNBC or Head & Neck Cancer (Ph1) and NSCLC or Melanoma (Ph2) [Phase 1, Phase 2]
This document is a completed Phase 1/Phase 2 clinical trial update for CAB-ROR2-ADC evaluating safety and efficacy in non-small cell lung ca…
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CLINICAL_TRIALS research · 2025-01-15Clinical Trial Update: A Study of Adebrelimab in Combination with Chemo with or Without Bevacizumab Neoadjuvant Therapy for Resectable NSCLC [Phase 2]
A Phase 2 clinical trial is evaluating Adebrelimab in combination with chemotherapy, with or without Bevacizumab, as neoadjuvant therapy for…
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CLINICAL_TRIALS research · 2025-01-15Clinical Trial Update: A Clinical Trial to Evaluate Effect of IAP0971 in Patients With Advanced Malignant Tumors [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating the safety and early signals of efficacy of IAP0971 in patients with advanced malignant tumors, includ…
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CLINICAL_TRIALS other · 2025-01-15Clinical Trial Update: Evaluation of JSKN016 in the Treatment of Advanced Non-small Cell Lung Cance： a Phase II Clinical Study [Phase 2]
A Phase II clinical trial evaluating JSKN016 for advanced non-small cell lung cancer, currently not yet recruiting.
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CLINICAL_TRIALS research · 2025-01-15Clinical Trial Update: Comprehensive Demographics and Clinical Profile of NSCLC Patients
This clinical trial update provides the demographics and clinical profile of patients with non-small cell lung cancer in NCT06725537; the st…
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CLINICAL_TRIALS withdrawal · 2025-01-15Clinical Trial Update: A Study of ASP1893 in Adults With Advanced CLDN6-positive Solid Tumors [Phase 1]
A Phase 1 trial evaluating ASP1893 in adults with CLDN6-positive solid tumors has been withdrawn.
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CLINICAL_TRIALS trial_result · 2025-01-14Clinical Trial Update: Study of Sacituzumab Govitecan (SG) Versus Docetaxel in Participants With Advanced or Metastatic Non-Small Cell Lung Cancer (NSCLC) [Phase 3]
A Phase 3 trial comparing Sacituzumab Govitecan to Docetaxel in advanced or metastatic non-small cell lung cancer has results posted as of 2…
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CLINICAL_TRIALS trial_result · 2025-01-14Clinical Trial Update: CCL21-Gene Modified Dendritic Cell Vaccine and Pembrolizumab in Treating Patients With Stage IV Non-small Cell Lung Cancer [Phase 1]
This Phase 1 clinical trial investigates a CCL21-gene modified dendritic cell vaccine in combination with pembrolizumab for stage IV non-sma…
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CLINICAL_TRIALS trial_result · 2025-01-14Clinical Trial Update: Osimertinib and Bevacizumab Versus Osimertinib Alone as Second-line Treatment in Stage IIIb-IVb NSCLC With Confirmed EGFRm and T790M [Phase 2]
A Phase 2 trial comparing osimertinib plus bevacizumab versus osimertinib alone as second-line treatment in metastatic non-small cell lung c…
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CLINICAL_TRIALS other · 2025-01-14Clinical Trial Update: A Post Approval Commitment Study on Tabrecta® (Capmatinib) in South Korea
This document reports a post-approval commitment study of Capmatinib (Tabrecta) in South Korea, currently recruiting for Non-Small Cell Lung…
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CLINICAL_TRIALS trial_result · 2025-01-14Clinical Trial Update: Immunotherapy in Combination With Chemoradiation in Patients With Advanced Solid Tumors [Phase 1]
A Phase 1 trial update reports completion of a study evaluating an immunotherapy in combination with chemoradiation for advanced solid tumor…
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CLINICAL_TRIALS research · 2025-01-14Clinical Trial Update: A Study to Describe the Diagnostic and Therapeutic Path of Patients with NSCLC in Early Stage and Locally Advanced
A ClinicalTrials.gov study sponsored by MSD Italia aims to describe how patients with early-stage and locally advanced non-small cell lung c…
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CLINICAL_TRIALS research · 2025-01-13Clinical Trial Update: The Efficacy and Safety of Ensartinib As Adjuvant Therapy in Stage I ALK-positive NSCLC Patients with High Risk Factors [Phase 2]
A Phase 2 clinical trial evaluating ensartinib as adjuvant therapy for stage I ALK-positive non-small cell lung cancer with high-risk factor…
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CLINICAL_TRIALS research · 2025-01-10Clinical Trial Update: A Value-Driven Study on Reducing Immune Checkpoint Inhibitor Dosing Frequency in Advanced Cancers [Phase 2]
This Phase 2 trial aims to evaluate whether reducing the dosing frequency of immune checkpoint inhibitors is feasible across advanced cancer…
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CLINICAL_TRIALS research · 2025-01-10Clinical Trial Update: A Phase II Study of AK112 (PD1/VEGF Bispecific) in Combination with Chemotherapy in Patients with NSCLC [Phase 2]
This document reports a Phase II clinical trial evaluating AK112, a PD-1/VEGF bispecific, in combination with chemotherapy for non-small cel…
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CLINICAL_TRIALS research · 2025-01-10Clinical Trial Update: The Accuracy of Targeted Lymph Node Dissection of Non-small Cell Lung Cancer Patients According to Predictive Models [NA]
Clinical trial update examining the accuracy of targeted lymph node dissection in non-small cell lung cancer using predictive models; the st…
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CLINICAL_TRIALS research · 2025-01-10Clinical Trial Update: The Effect of Beta-glucan in Non-Small Cell Lung Cancer [NA]
A clinical trial evaluating beta-glucan in non-small cell lung cancer is currently recruiting, sponsored by the University of Louisville.