Nicotine Dependence
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2011-04-18Clinical Trial Update: St. John's Wort for Tobacco Cessation [Phase 2]
A Phase 2 clinical trial evaluated St. John's Wort for tobacco cessation conducted by Mayo Clinic; the study is completed and results were p…
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CLINICAL_TRIALS trial_result · 2010-12-20Clinical Trial Update: Effectiveness of GW468816, an NMDA Glycine Site Antagonist, for Prevention of Relapse to Smoking [Phase 2]
Phase 2 trial evaluating GW468816, an NMDA glycine site antagonist, for prevention of relapse to smoking; results posted.
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CLINICAL_TRIALS trial_result · 2010-12-10Clinical Trial Update: Comparison of Efficacy and Safety of Rimonabant 20mg/Day Versus Placebo in Smoking Cessation [Phase 3]
Phase 3 trial comparing the efficacy and safety of rimonabant 20 mg daily versus placebo for smoking cessation.
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CLINICAL_TRIALS trial_result · 2010-12-10Clinical Trial Update: Comparison of the Efficacy and Safety of 2 Oral Doses of Rimonabant, 5 mg/Day or 20 mg/Day, Versus Placebo, as an Aid to Smoking Cessation (STRATUS US) [Phase 3]
A Phase 3 trial comparing two daily doses of rimonabant (5 mg and 20 mg) to placebo for smoking cessation has completed. The STRATUS US stud…
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CLINICAL_TRIALS trial_result · 2010-11-15Clinical Trial Update: Efficacy and Safety of Nicotine-Qbeta Vaccine in Smokers [Phase 2]
Phase 2 trial assessing the efficacy and safety of the Nicotine-Qbeta Vaccine in smokers has completed.
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CLINICAL_TRIALS trial_result · 2010-11-02Clinical Trial Update: Comparison of Standard Versus Extended Nicotine Patch Therapy for Smoking Cessation [Phase 3]
Phase 3 clinical trial comparing standard versus extended nicotine patch therapy for smoking cessation; results were posted in 2010.
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CLINICAL_TRIALS trial_result · 2010-11-01Clinical Trial Update: Testing Methylphenidate for Smoking Abstinence [Phase 2]
Phase 2 clinical trial assessing whether methylphenidate supports smoking abstinence; results have been posted.
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CLINICAL_TRIALS trial_result · 2010-10-01Clinical Trial Update: Behavioral/Drug Therapy for Alcohol-Nicotine Dependence (Naltrexone/Nicotine Patch) [Phase 4]
Phase 4 trial update on combined behavioral therapy with naltrexone and a nicotine patch for people with alcohol use disorder and nicotine d…
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CLINICAL_TRIALS trial_result · 2010-09-21Clinical Trial Update: Naltrexone and Varenicline: Weight Gain and Tolerability in Cigarette Smokers [Phase 1, Phase 2]
A combined Phase 1/2 trial assessing weight gain and tolerability of naltrexone and varenicline in smokers.
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CLINICAL_TRIALS trial_result · 2010-09-15Clinical Trial Update: Combined Nortriptyline and Transdermal Nicotine for Smoking Cessation [Phase 2]
Phase 2 trial evaluating combined nortriptyline and a transdermal nicotine patch for smoking cessation; the study has completed.
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CLINICAL_TRIALS trial_result · 2010-09-06Clinical Trial Update: A Twelve-Week Study of Varenicline for Safety and Efficacy in Comparison With Placebo for Smoking Cessation [Phase 3]
A twelve-week Phase 3 trial comparing varenicline to placebo for smoking cessation demonstrated safety and efficacy. The study was sponsored…
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CLINICAL_TRIALS trial_result · 2010-08-17Clinical Trial Update: Effects of Chantix on Relapse Prevention for Smoking Cessation [Phase 4]
This Phase 4 study evaluates varenicline (Chantix) for relapse prevention in people attempting to quit smoking.
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CLINICAL_TRIALS trial_result · 2010-05-19Clinical Trial Update: Smoking Cessation in Alcoholism Treatment [Phase 4]
A Phase 4 clinical trial evaluating smoking cessation strategies in individuals with alcohol use disorder has completed.
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CLINICAL_TRIALS trial_result · 2010-04-14Clinical Trial Update: The Pharmacogenetic Study , Readiness to Change, and Pharmacological Intervention for Smoking Cessation in Schizophrenia [Phase 4]
Phase 4 clinical trial update investigating pharmacogenetics, readiness to change, and pharmacological smoking cessation in individuals with…
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CLINICAL_TRIALS trial_result · 2010-04-06Clinical Trial Update: Functional Magnetic Resonance Imaging (fMRI) Investigation of Nicotine Withdrawal Symptoms [Phase 4]
A Phase 4 trial sponsored by GlaxoSmithKline used functional MRI to investigate nicotine withdrawal symptoms in smokers; the study has compl…
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CLINICAL_TRIALS trial_result · 2010-03-19Clinical Trial Update: Bio-Behavioral Predictors of the Efficacy of Nicotine Replacement Therapy (NRT) [Phase 4]
A Phase 4 study completed in 2010 examined bio-behavioral predictors of how well nicotine replacement therapy works for quitting smoking.
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CLINICAL_TRIALS trial_result · 2010-01-11Clinical Trial Update: Multiple Dose, Dose Escalation Study of Varenicline Controlled Release Formulation in Adult Smokers [Phase 1]
Phase 1 dose-escalation trial evaluating a controlled-release formulation of varenicline in adult smokers has completed.
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CLINICAL_TRIALS trial_result · 2009-12-04Clinical Trial Update: Study of Lunesta Versus Placebo for Sleep Problems Related to Smoking Cessation and Zyban [Phase 4]
A Phase 4 trial comparing Lunesta to placebo for sleep problems related to smoking cessation; the study was terminated with results posted i…
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CLINICAL_TRIALS trial_result · 2009-09-15Clinical Trial Update: Smoking Cessation in Groups and With Tobacco Pastils [Phase 2]
Phase 2 trial evaluating smoking cessation methods using group sessions and nicotine pastilles has completed. No results are provided in the…
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CLINICAL_TRIALS trial_result · 2009-05-29Clinical Trial Update: Phase II Study to Evaluate the Effectiveness of EVT 302 in Smoking Cessation. [Phase 2]
Phase II clinical trial evaluating EVT 302 for smoking cessation has completed, assessing its effectiveness in helping participants quit smo…
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CLINICAL_TRIALS trial_result · 2009-04-29Clinical Trial Update: Efficacy and Safety of Varenicline in Smokers With Cardiovascular Disease Who Wish to Quit Smoking [Phase 3]
Phase 3 trial update on varenicline for smoking cessation in smokers with cardiovascular disease, reporting efficacy and safety results. Res…
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CLINICAL_TRIALS trial_result · 2009-04-20Clinical Trial Update: Efficacy and Safety of Rimonabant as an Aid to Smoking Cessation With or Without Nicotine Patch [Phase 3]
A Phase 3 trial conducted by Sanofi assessed the efficacy and safety of rimonabant as an aid to smoking cessation with or without a nicotine…
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CLINICAL_TRIALS trial_result · 2009-03-18Clinical Trial Update: Neural Inhibition as a Mechanism of Nicotine Dependence Among Persons With Schizophrenia [NA]
A completed clinical trial update evaluating neural inhibition as a mechanism of nicotine dependence in people with schizophrenia and relate…
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CLINICAL_TRIALS trial_result · 2009-03-02Clinical Trial Update: Fluoxetine as a Quit Smoking Aid for Depression-Prone Smokers [Phase 3]
This document notes the completion of a Phase 3 clinical trial evaluating fluoxetine as a smoking-cessation aid in depression-prone smokers,…
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CLINICAL_TRIALS trial_result · 2009-01-26Clinical Trial Update: A Study Evaluating The Absorption Of Varenicline Into The Body From A Varenicline Solution And A Varenicline Patch Applied To The Skin [Phase 1]
This Phase 1 study evaluated how varenicline is absorbed into the body from a varenicline solution and from a skin patch.