Nicotine Dependence
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2026-08-20Clinical Trial Results: Methadone-Maintained Smokers Switching to E-Cigarettes [Phase 4]
Phase 4 trial evaluating methadone-maintained smokers switching to electronic cigarettes; results completed and posted.
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CLINICAL_TRIALS trial_result · 2026-07-31Clinical Trial Results: Racial Differences in Circadian and Sleep Mechanisms for Nicotine Dependence, Craving, and Withdrawal [NA]
Clinical trial results examining racial differences in circadian and sleep mechanisms related to nicotine dependence, craving, and withdrawa…
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CLINICAL_TRIALS trial_result · 2026-06-17Clinical Trial Results: Cessation Screening Project [Phase 4]
Phase 4 trial results for the Cessation Screening Project in nicotine dependence have been completed with results posted.
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CLINICAL_TRIALS trial_result · 2026-06-16Clinical Trial Results: Effects of Menthol in E-cigarettes on Smoking Behaviors [Phase 1]
Phase 1 clinical trial evaluating the effects of menthol in e-cigarettes on smoking behaviors.
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CLINICAL_TRIALS trial_result · 2026-06-04Clinical Trial Update: Optimizing Tobacco Use Treatment for PLWHA [Phase 3]
Phase 3 trial update on optimizing tobacco use treatment for people living with HIV/AIDS, focusing on nicotine dependence in HIV-infected in…
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Varenicline for Smoking Reduction in Veterans Not Ready To Quit [Phase 4]
Phase 4 clinical trial update for varenicline aimed at reducing smoking in veterans not ready to quit; the study status is not yet recruitin…
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Advanced Functional and Structural MRI Techniques for Neuropharmacological Imaging [NA]
This update describes an ongoing clinical trial sponsored by NIDA using advanced functional and structural MRI techniques to study neurophar…
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: Social Media Support Groups for Adolescent Vaping Cessation [NA]
A clinical trial update about an adolescent vaping cessation study using social media support groups, sponsored by the University of Califor…
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CLINICAL_TRIALS research · 2026-04-21Clinical Trial Update: Accelerated dTMS Smoking Cessation [Phase 2]
Phase 2 trial update for accelerated deep transcranial magnetic stimulation (dTMS) for smoking cessation; the study is currently recruiting.
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CLINICAL_TRIALS research · 2026-04-21Clinical Trial Update: A Digital Intervention (ACT on Vaping App) for Vaping Cessation in Young Adult E-Cigarette Users [NA]
A clinical trial is evaluating a digital intervention app (ACT on Vaping) to aid vaping cessation in young adults; the study is not yet recr…
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: Pharmacist Intervention to Improve Smoking Cessation [NA]
A University of Iowa study is evaluating a pharmacist intervention to improve smoking cessation; the trial is currently active but not recru…
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: A Study of Brenipatide in Adults Who Quit Smoking Cigarettes and Want to Avoid Relapse [Phase 2]
Phase 2 study to evaluate Brenipatide for relapse prevention in adults who have quit smoking.
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CLINICAL_TRIALS trial_result · 2026-04-16Clinical Trial Update: Switching Individuals in Treatment for Opioid Use Disorder Who Smoke Cigarettes to the SREC [NA]
A clinical trial update reports that the study assessing people with opioid use disorder who smoke cigarettes and switch to SREC has complet…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: RTMS Targets Neural Circuits for Smoking Cessation [NA]
A clinical trial is investigating repetitive transcranial magnetic stimulation as a potential approach to aid smoking cessation; the study i…
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CLINICAL_TRIALS trial_result · 2026-04-15Clinical Trial Update: Effectiveness of a Smoking Cessation Algorithm Integrated Into HIV Primary Care [Phase 4]
Phase 4 study results evaluating an algorithm for smoking cessation integrated into HIV primary care.
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CLINICAL_TRIALS trial_result · 2026-04-15Clinical Trial Update: Effect of Helpers Program On-line Training on Smoking Relapse and Social Networks [NA]
University of Colorado, Denver sponsors a clinical trial that is active but not recruiting. The study evaluates an online Helpers Program de…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Testing the Feasibility and Acceptability of Social Media and Digital Therapeutics to Decrease Vaping Behaviors [Phase 1]
Phase 1 clinical trial to evaluate the feasibility and acceptability of using social media and digital therapeutics to reduce vaping behavio…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Orexin s Role in the Neurobiology of Substance Use Disorder [NA]
An ongoing clinical trial sponsored by NIDA investigates the role of orexin in the neurobiology of nicotine dependence. The study is current…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: The Avenues Study: Dual Use Cessation [Phase 4]
The Avenues Study is a Phase 4 clinical trial evaluating strategies for dual use cessation of tobacco products and electronic cigarettes, cu…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Auricular Stimulation for Nicotine Withdrawal in Psychiatric Inpatients [NA]
A clinical trial is evaluating auricular stimulation for nicotine withdrawal in psychiatric inpatients; recruitment is ongoing.
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CLINICAL_TRIALS research · 2026-04-06Clinical Trial Update: Comparing an Opt-out to an opt-in Approach for Smoking Cessation in VA Primary Care Clinics [NA]
A clinical trial update describing a study that compares opt-out versus opt-in approaches for smoking cessation in VA primary care clinics; …
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CLINICAL_TRIALS research · 2026-04-03Clinical Trial Update: Neuroimaging Approaches to Improve Prediction of Smoking Initiation and Nicotine Escalation in Young Adult ENDS Users [NA]
An ongoing University of Georgia study using neuroimaging to predict smoking initiation and nicotine escalation in young adult ENDS users, c…
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CLINICAL_TRIALS research · 2026-04-03Clinical Trial Update: PASCAL Feasibility Study [NA]
The PASCAL Feasibility Study is a University of Minnesota–sponsored trial assessing smoking cessation, with recruitment not yet started.
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CLINICAL_TRIALS research · 2026-04-02Clinical Trial Update: Neurobehavioral Mechanisms Linking Childhood Adversity to Increased Risk for Smoking [EARLY_Phase 1]
An early-phase study investigating neurobehavioral mechanisms by which adverse childhood experiences may increase the risk of nicotine depen…
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CLINICAL_TRIALS research · 2026-03-31Clinical Trial Update: Cognitive Task Development and Implementation for Functional MRI Studies
The NIDA-sponsored study reports the development and deployment of cognitive tasks for functional MRI studies in the context of drug abuse a…