Neuroblastoma
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CLINICAL_TRIALS trial_result · 2025-09-16Clinical Trial Update: 67Cu-SARTATE™ Peptide Receptor Radionuclide Therapy Administered to Pediatric Patients With High-Risk, Relapsed, Refractory Neuroblastoma [Phase 1, Phase 2]
A pediatric Phase 1/2 trial of the radiopharmaceutical 67Cu-SARTATE for high-risk, relapsed, or refractory neuroblastoma has been terminated…
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CLINICAL_TRIALS trial_result · 2025-09-15Clinical Trial Update: NANT 2015-02: A Phase 1 Study of Lorlatinib (PF-06463922) [Phase 1]
This update reports the completion of a Phase 1 study of lorlatinib (PF-06463922) in neuroblastoma. Results from the trial have been posted.
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CLINICAL_TRIALS research · 2025-09-15Clinical Trial Update: Quadruple Immunotherapy for Neuroblastoma [Phase 2]
Phase 2 clinical trial evaluating quadruple immunotherapy for recurrent Neuroblastoma, currently recruiting.
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CLINICAL_TRIALS research · 2025-09-12Clinical Trial Update: Interest of Preoperative Arteriography to Identify the Adamkiewicz Artery Before Surgery for Basi-thoracic Neuroblastic Tumors
Clinical trial update evaluating preoperative arteriography to identify the Adamkiewicz artery before surgery for basi-thoracic neuroblastic…
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CLINICAL_TRIALS withdrawal · 2025-09-10Clinical Trial Update: Testing the Combination of Two Immunotherapy Drugs (Nivolumab and Ipilimumab) in Children, Adolescent, and Young Adult Patients With Relapsed/Refractory Cancers That Have an Increased Number of Genetic Changes, The 3CI Study [Phase 1]
This document reports the withdrawal of a Phase 1 trial evaluating the combination of nivolumab and ipilimumab in pediatric and young adult …
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CLINICAL_TRIALS research · 2025-09-03Clinical Trial Update: Comparison of 18F Labeled Analog of MIBG (18F-MFBG) PET/CT and 123I-MIBG SPECT in Pediatric Patients With Neuroblastoma. [Phase 2]
This update describes a Phase 2 clinical trial comparing 18F-MFBG PET/CT to 123I-MIBG SPECT imaging in pediatric patients with neuroblastoma…
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CLINICAL_TRIALS research · 2025-09-03Clinical Trial Update: Fertility Preservation in Children With Solid Tumors: Detection of Residual Disease by a Sensitive Method
This clinical trial investigates fertility preservation in children with solid tumors and evaluates detection of residual disease using a hi…
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CLINICAL_TRIALS trial_result · 2025-09-02Clinical Trial Update: Evaluation of 2 Intensification Treatment Strategies for Neuroblastoma Patients With a Poor Response to Induction [Phase 2]
This update reports a Phase 2 trial evaluating two intensified treatment strategies for patients with very high-risk neuroblastoma who had a…
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CLINICAL_TRIALS research · 2025-08-12Clinical Trial Update: A Study of Cabozantinib as a Maintenance Agent to Prevent Progression or Recurrence in High-Risk Pediatric Solid Tumors [Phase 2]
Phase 2 trial evaluating cabozantinib as maintenance therapy to prevent progression or recurrence in high-risk pediatric solid tumors is cur…
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CLINICAL_TRIALS research · 2025-08-08Clinical Trial Update: 18F-mFBG PET Imaging in the Evaluation of Neuroblastoma
This clinical trial update outlines a study evaluating 18F-mFBG PET imaging for the assessment of neuroblastoma, currently in recruitment.
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CLINICAL_TRIALS trial_result · 2025-08-06Clinical Trial Update: A Study of Abemaciclib (LY2835219) in Combination With Other Anti-Cancer Treatments in Children and Young Adult Participants With Solid Tumors, Including Neuroblastoma [Phase 1, Phase 2]
Phase 1/2 study evaluating abemaciclib in combination with other anti-cancer therapies in children and young adults with solid tumors, inclu…
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CLINICAL_TRIALS research · 2025-08-05Clinical Trial Update: A Study of N9 Chemotherapy in Children With Neuroblastoma [EARLY_Phase 1]
An early-phase Phase 1 study evaluating N9 chemotherapy in children with neuroblastoma. The trial is currently active but not recruiting.
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CLINICAL_TRIALS trial_result · 2025-08-01Clinical Trial Update: Allogeneic Tumor Cell Vaccination With Oral Metronomic Cytoxan in Patients With High-Risk Neuroblastoma [Phase 1, Phase 2]
Clinical trial update for high-risk neuroblastoma evaluating allogeneic tumor cell vaccination with oral metronomic cyclophosphamide (Phase …
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CLINICAL_TRIALS trial_result · 2025-07-30Clinical Trial Update: Humanized Anti-GD2 Antibody Hu3F8 and Allogeneic Natural Killer Cells for High-Risk Neuroblastoma [Phase 1]
Phase 1 study evaluating the combination of Hu3F8, a humanized anti-GD2 antibody, with allogeneic natural killer cells for high-risk neurobl…
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CLINICAL_TRIALS research · 2025-07-29Clinical Trial Update: GSL Synthetase Inhibitor Plus GM-CSF and/ or Immune Checkpoint Inhibitor in Previously Treated High-Risk Neuroblastoma. [EARLY_Phase 1]
An early-phase clinical trial evaluating a GSL Synthetase Inhibitor in combination with GM-CSF and/or an immune checkpoint inhibitor for pre…
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CLINICAL_TRIALS research · 2025-07-29Clinical Trial Update: Safety & Efficacy of IR-101 in Relapsed/Refractory Neuroblastoma [EARLY_Phase 1]
An early-phase (Phase 1) clinical trial evaluating the safety and efficacy of IR-101 for relapsed/refractory neuroblastoma is currently recr…
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CLINICAL_TRIALS research · 2025-07-29Clinical Trial Update: Parental Decision-Making for Children With Relapsed Neuroblastoma
Clinical trial update from Dana-Farber Cancer Institute examining parental decision-making for children with relapsed neuroblastoma; the stu…
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CLINICAL_TRIALS research · 2025-07-25Clinical Trial Update: C7R-GD2.CART Cells for Patients With Relapsed or Refractory Neuroblastoma and Other GD2 Positive Cancers (GAIL-N) [Phase 1]
ClinicalTrials.gov entry updates the Phase 1 study of C7R-GD2.CART cells for relapsed or refractory GD2-positive cancers, including neurobla…
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CLINICAL_TRIALS research · 2025-07-23Clinical Trial Update: Expanded Access Protocol for the Use of SL-28 in the Treatment of Advanced Solid Tumors
This clinical trials update describes an expanded access protocol for SL-28 in patients with advanced solid tumors and lists eligible condit…
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CLINICAL_TRIALS research · 2025-07-22Clinical Trial Update: 131I-Labeled MIBG for Refractory Neuroblastoma: A Compassionate Use Protocol
This document reports a compassionate-use protocol for 131I-labeled metaiodobenzylguanidine (MIBG) to treat refractory neuroblastoma.
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CLINICAL_TRIALS research · 2025-07-22Clinical Trial Update: SIOPEN BIOPORTAL, An International Registry Linked to a Virtual Biobank for Patients With Peripheral Neuroblastic Tumours [NA]
The SIOPEN BIOPORTAL is an international registry connected to a virtual biobank for patients with peripheral neuroblastic tumors, with recr…
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CLINICAL_TRIALS trial_result · 2025-07-21Clinical Trial Update: Clinical Application Study of [123I]Metaiodobenzylguanidine and Somatostatin Receptor-Targeted Imaging in the Diagnosis and Staging of Neuroblastoma
This clinical trial update describes an imaging-based diagnostic study using [123I]Metaiodobenzylguanidine and somatostatin receptor-targete…
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CLINICAL_TRIALS trial_result · 2025-07-17Clinical Trial Update: 9-ING-41 in Pediatric Patients With Refractory Malignancies. [Phase 1]
Phase 1 trial of 9-ING-41 in pediatric patients with refractory malignancies was terminated; the update does not include study results.
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CLINICAL_TRIALS trial_result · 2025-07-17Clinical Trial Update: Biomarkers of Renal Dysfunction in Neuroblastoma Survivors
A completed clinical trial from Memorial Sloan Kettering Cancer Center examining biomarkers of renal dysfunction in survivors of neuroblasto…
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CLINICAL_TRIALS trial_result · 2025-07-14Clinical Trial Update: Feasibility Study of Prolonged Administration of Naxitamab, Irinotecan, and Temozolomide for Patients With Relapsed or Refractory Neuroblastoma [Phase 1]
Phase 1 feasibility trial evaluating prolonged naxitamab, irinotecan, and temozolomide in relapsed or refractory neuroblastoma; the study is…