Neuroblastoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2025-07-08Clinical Trial Update: Study Combining Dinutuximab Beta With Two Chemotherapy Regimens in Neuroblastoma [Phase 1]
Phase 1 clinical trial updating study design to combine dinutuximab beta with two chemotherapy regimens for neuroblastoma; recruiting.
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CLINICAL_TRIALS trial_result · 2025-07-04Clinical Trial Update: A Phase I/II Study Of Immunization With Lymphotactin And Interleukin 2 Gene Modified Neuroblastoma Tumor Cells [Phase 1, Phase 2]
Phase I/II trial evaluating immunization with lymphotactin and interleukin-2 gene-modified neuroblastoma tumor cells; study has completed.
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CLINICAL_TRIALS research · 2025-07-02Clinical Trial Update: Study of Chemoimmunotherapy for High-Risk Neuroblastoma [EARLY_Phase 1]
An early-phase Phase 1 trial evaluating chemoimmunotherapy for high-risk neuroblastoma conducted by Memorial Sloan Kettering Cancer Center i…
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CLINICAL_TRIALS trial_result · 2025-06-29Clinical Trial Update: Donor Stem Cell Transplant After Chemotherapy for the Treatment of Recurrent or Refractory High-Risk Solid Tumors in Pediatric and Adolescent-Young Adults [Phase 2]
A Phase 2 trial evaluating donor stem cell transplant after chemotherapy for recurrent or refractory high-risk solid tumors in pediatric and…
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CLINICAL_TRIALS research · 2025-06-26Clinical Trial Update: High-Risk Neuroblastoma Study 2 of SIOP-Europa-Neuroblastoma (SIOPEN) [Phase 3]
Phase 3 clinical trial update for high-risk neuroblastoma under the SIOP-Europa-Neuroblastoma (SIOPEN) consortium; the study is currently re…
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EMA approval · 2025-06-18EMA Authorised: Phelinun (melphalan hydrochloride) — ADIENNE S.r.l. S.U.
The EMA authorised Phelinun (melphalan hydrochloride) for multiple cancers including multiple myeloma, Hodgkin lymphoma, non-Hodgkin lymphom…
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CLINICAL_TRIALS research · 2025-06-17Clinical Trial Update: Clinical Analysis of Naxitamab (hu3F8) in the Treatment of Pediatric High Risk or Refractory/ Relapsed Neuroblastoma [Phase 2]
A Phase 2 clinical trial update for Naxitamab (hu3F8) in pediatric high-risk or refractory/recurrent neuroblastoma (NCT06013618) is currentl…
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CLINICAL_TRIALS research · 2025-06-05Clinical Trial Update: Bivalent Vaccine With Escalating Doses of the Immunological Adjuvant OPT-821, in Combination With Oral β-glucan for High-Risk Neuroblastoma [Phase 1, Phase 2]
Clinical trial update on a bivalent vaccine using the OPT-821 adjuvant with oral beta-glucan for high-risk neuroblastoma. The Phase 1/2 stud…
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CLINICAL_TRIALS trial_result · 2025-06-03Clinical Trial Update: Tipifarnib for the Treatment of Advanced Solid Tumors, Lymphoma, or Histiocytic Disorders With HRAS Gene Alterations, a Pediatric MATCH Treatment Trial [Phase 2]
Phase 2 pediatric MATCH trial results for Tipifarnib in HRAS-altered solid tumors and histiocytic disorders; the study has posted results an…
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CLINICAL_TRIALS research · 2025-05-28Clinical Trial Update: Engineered Neuroblastoma Cellular Immunotherapy (ENCIT)-01 [Phase 1]
Phase 1 clinical trial evaluating ENCIT-01, an engineered neuroblastoma cellular immunotherapy, in patients with neuroblastoma or ganglioneu…
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CLINICAL_TRIALS trial_result · 2025-05-21Clinical Trial Update: Phase II Study of Combined Chemotherapy With Arsenic Trioxide in Stage 4/M Neuroblastoma [Phase 2]
Phase II clinical trial evaluating arsenic trioxide in combination with chemotherapy for stage 4/M neuroblastoma; results posted on 2025-05-…
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CLINICAL_TRIALS research · 2025-05-15Clinical Trial Update: Risk Model for Metastasis Detection of Neuroblastoma
Clinical trial update describing a study to develop a risk model for detecting metastasis in neuroblastoma, currently enrolling by invitatio…
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CLINICAL_TRIALS research · 2025-05-13Clinical Trial Update: NK Cells Infusions With Irinotecan, Temozolomide, and Dinutuximab [Phase 1, Phase 2]
An ongoing Phase 1/2 clinical trial is evaluating NK cell infusions in combination with irinotecan, temozolomide, and dinutuximab for relaps…
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CLINICAL_TRIALS research · 2025-05-02Clinical Trial Update: Collecting and Storing Tissue From Young Patients With Cancer
A completed clinical trial update from the Children’s Oncology Group describing the collection and storage of tissue from pediatric cancer p…
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CLINICAL_TRIALS research · 2025-04-29Clinical Trial Update: A Clinical Trial on Autologous NK Cells Combined With GD2 Monoclonal Antibody in the Treatment of Children With Newly Diagnosed High-risk or Relapsed/Refractory Neuroblastoma [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating autologous natural killer (NK) cells in combination with a GD2-targeted monoclonal antibody for newly …
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CLINICAL_TRIALS research · 2025-04-24Clinical Trial Update: Autologous B7-H3 Chimeric Antigen Receptor T Cells in Relapsed/Refractory Solid Tumors [Phase 1]
Phase 1 trial evaluating autologous B7-H3 CAR T cells in relapsed/refractory solid tumors, including neuroblastoma, sarcoma, and osteosarcom…
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CLINICAL_TRIALS research · 2025-04-18Clinical Trial Update: Arsenic Trioxide With MAPK Inhibitors and Chemotherapy for Stage 4/M Neuroblastoma [Phase 2]
Phase 2 clinical trial evaluating arsenic trioxide in combination with MAPK inhibitors and chemotherapy for stage 4/metastatic neuroblastoma…
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CLINICAL_TRIALS trial_result · 2025-04-16Clinical Trial Update: MIBG With Dinutuximab +/- Vorinostat [Phase 1]
Phase 1 trial evaluating MIBG with dinutuximab, with or without vorinostat, in neuroblastoma has completed and posted results.
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CLINICAL_TRIALS research · 2025-04-09Clinical Trial Update: Safety and Efficacy of Systemic Allogenic NK Cells in R/R Neuroblastoma [Phase 1]
Phase 1 trial assessing safety and efficacy of systemic allogeneic NK cells in relapsed/refractory neuroblastoma; currently recruiting.
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CLINICAL_TRIALS trial_result · 2025-03-19Clinical Trial Update: GVAX Plus Checkpoint Blockade in Neuroblastoma [Phase 1]
The Phase 1 trial of GVAX plus checkpoint blockade in neuroblastoma was terminated.
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CLINICAL_TRIALS trial_result · 2025-03-19Clinical Trial Update: Phase 2 STIR Trial: Haploidentical Transplant and Donor Natural Killer Cells for Solid Tumors [Phase 2]
Phase 2 trial update of haploidentical transplantation with donor natural killer cells for solid tumors; the study was terminated and result…
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CLINICAL_TRIALS research · 2025-03-18Clinical Trial Update: Biological Characterisation of High Risk CHildhood Cancer in Children, Adolescents and Young Adults (MICCHADO) [NA]
This entry reports on the MICCHADO trial, which investigates the biological characterization of high-risk childhood cancers. The sponsor is …
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CLINICAL_TRIALS trial_result · 2025-02-28Clinical Trial Update: Β3-adrenoreceptor As Prognostic Marker in Neuroblastoma and Ewing Sarcoma [NA]
This completed clinical trial evaluates Beta-3 adrenergic receptor as a prognostic biomarker in neuroblastoma and Ewing sarcoma.
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CLINICAL_TRIALS research · 2025-02-26Clinical Trial Update: Safety and Efficacy of CAR-T Cell Therapy for Relapsed/refractory Neuroblastoma and Desmoplastic Small Round Cell Tumors: a Single-arm, Open-label Trial. [Phase 1, Phase 2]
This document outlines an ongoing single-arm, open-label Phase 1/2 trial assessing the safety and efficacy of CAR-T cell therapy in relapsed…
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CLINICAL_TRIALS research · 2025-02-25Clinical Trial Update: APG-115 Alone or in Combination With APG-2575 in Children With Recurrent or Refractory Neuroblastoma or Solid Tumors [Phase 1]
Ascentage Pharma is conducting a Phase 1 trial of APG-115 alone or in combination with APG-2575 in children with recurrent or refractory neu…