Myeloproliferative Neoplasms
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2024-05-29Clinical Trial Update: Assessing Feasibility of Thromboprophylaxis With Apixaban in JAK2-positive Myeloproliferative Neoplasm Patients [Phase 2]
Phase 2 feasibility study evaluating apixaban for thromboprophylaxis in patients with JAK2-positive myeloproliferative neoplasms (including …
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CLINICAL_TRIALS trial_result · 2024-05-07Clinical Trial Update: Benadamustine, Fludarabine and Busulfan Conditioning in Recipients of Haploidentical Stem Cell Transplantation (FluBuBe) [Phase 2]
This Phase 2 clinical trial update reports on conditioning with benadamustine, fludarabine, and busulfan (FluBuBe) for recipients of haploid…
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CLINICAL_TRIALS trial_result · 2024-05-01Clinical Trial Update: A Study of INCB050465 in Combination With Ruxolitinib in Subjects With Myelofibrosis [Phase 2]
Phase 2 study of INCB050465 in combination with ruxolitinib for myelofibrosis. The trial was terminated and results were posted in May 2024.
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CLINICAL_TRIALS trial_result · 2023-11-21Clinical Trial Update: Pevonedistat and Azacitidine in MDS or MDS/MPN Patients Who Fail Primary Therapy With DNA Methyl Transferase Inhibitors [Phase 2]
Phase 2 trial evaluating pevonedistat in combination with azacitidine for patients with myelodysplastic syndromes or myeloproliferative neop…
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CLINICAL_TRIALS trial_result · 2023-01-06Clinical Trial Update: Open-Label, Dose-Escalation Study of Pemigatinib in Subjects With Advanced Malignancies - (FIGHT-101) [Phase 1, Phase 2]
Open-label, dose-escalation study of pemigatinib in advanced malignancies (FIGHT-101) completed; results posted.
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CLINICAL_TRIALS trial_result · 2022-12-16Clinical Trial Update: Fludarabine and Busulfan vs. Fludarabine, Busulfan and Total Body Irradiation [Phase 3]
A Phase 3 randomized trial comparing Fludarabine and Busulfan versus Fludarabine, Busulfan plus Total Body Irradiation in patients with myel…
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CLINICAL_TRIALS trial_result · 2022-04-06Clinical Trial Update: A Phase II Study of SGI-110 in Philadelphia-Negative Myeloproliferative Neoplasms [Phase 2]
Phase II study of SGI-110 in Philadelphia-negative myeloproliferative neoplasms completed with posted results.
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CLINICAL_TRIALS trial_result · 2021-11-19Clinical Trial Update: Phase 2 Study of Ruxolitinib Versus Anagrelide in Subjects With Essential Thrombocythemia Who Are Resistant to or Intolerant of Hydroxyurea (RESET-272) [Phase 2]
Phase 2 study comparing ruxolitinib to anagrelide in essential thrombocythemia patients resistant to or intolerant of hydroxyurea; the trial…
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CLINICAL_TRIALS trial_result · 2021-08-30Clinical Trial Update: An Open Label Study of Itacitinib Administered Orally in Patients With Myelofibrosis [Phase 2]
Open-label Phase 2 trial of itacitinib in patients with myeloproliferative neoplasms has completed.
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CLINICAL_TRIALS trial_result · 2021-07-02Clinical Trial Update: A Study of Itacitinib in Combination With Low-Dose Ruxolitinib or Itacitinib Alone Following Ruxolitinib in Participants With Myelofibrosis [Phase 2]
Phase 2 trial evaluating itacitinib with low-dose ruxolitinib or itacitinib alone after ruxolitinib in myelofibrosis; trial completed with r…
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CLINICAL_TRIALS trial_result · 2020-01-28Clinical Trial Update: Ruxolitinib (INCB018424) in Participants With Primary Myelofibrosis (PMF), Post Essential Thrombocythemia-myelofibrosis and Post Polycythemia Vera-myelofibrosis (PPV-MF) [Phase 2]
Phase 2 trial assessing ruxolitinib (INCB018424) in participants with primary myelofibrosis and related post-MPN myelofibrosis conditions ha…
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CLINICAL_TRIALS trial_result · 2019-02-28Clinical Trial Update: Study of Combination Ruxolitinib and Decitabine Treatment for Accelerated Phase MPN or Post-MPN AML [Phase 1, Phase 2]
A trial evaluating the combination of ruxolitinib and decitabine in accelerated phase myeloproliferative neoplasms or post-MPN acute myeloid…
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CLINICAL_TRIALS trial_result · 2018-10-24Clinical Trial Update: Fludarabine Phosphate and Total Body Irradiation Followed by a Donor Peripheral Stem Cell Transplant in Treating Patients With Myelodysplastic Syndromes or Myeloproliferative Disorders [Phase 2]
Phase 2 clinical trial evaluating fludarabine phosphate and total body irradiation followed by donor peripheral stem cell transplant in myel…
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CLINICAL_TRIALS trial_result · 2018-05-31Clinical Trial Update: Clofarabine Plus Low-Dose Cytarabine for Patients With Higher-Risk Myelodysplastic Syndrome (MDS) [Phase 2]
Phase 2 clinical trial evaluating clofarabine plus low-dose cytarabine in higher-risk myelodysplastic syndromes has completed and results we…
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CLINICAL_TRIALS trial_result · 2018-04-17Clinical Trial Update: A Study in Myeloproliferative Disorders [Phase 1]
Phase 1 study in myeloproliferative neoplasms has completed, evaluating patients with essential thrombocythemia, polycythemia vera, and prim…
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CLINICAL_TRIALS trial_result · 2017-11-29Clinical Trial Update: Donor Umbilical Cord Blood Transplant in Treating Patients With Hematologic Cancer [NA]
ClinicalTrials.gov entry describes termination of a study evaluating donor umbilical cord blood transplantation for various hematologic canc…
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CLINICAL_TRIALS trial_result · 2017-09-25Clinical Trial Update: Pomalidomide in Patients With Myeloproliferative Neoplasms in Fibrotic Stage [Phase 2]
Phase 2 clinical trial update evaluating pomalidomide in patients with fibrotic-stage myeloproliferative neoplasms has completed.
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CLINICAL_TRIALS trial_result · 2017-07-19Clinical Trial Update: Fenretinide in Treating Patients With Refractory or Relapsed Hematologic Cancer [Phase 1]
A Phase 1 trial of fenretinide in patients with refractory or relapsed hematologic cancers has been completed, investigating safety across m…
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CLINICAL_TRIALS trial_result · 2017-07-17Clinical Trial Update: Allogeneic Hematopoietic Cell Transplantation for Patients With Busulfex-based Regimen [Phase 1, Phase 2]
A Phase 1/2 trial evaluating allogeneic hematopoietic cell transplantation using a busulfan-based conditioning regimen across multiple hemat…
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CLINICAL_TRIALS trial_result · 2017-06-28Clinical Trial Update: Sirolimus, Tacrolimus, and Antithymocyte Globulin in Preventing Graft-Versus-Host Disease in Patients With Hematologic Cancer Who Are Undergoing Donor Stem Cell Transplant [Phase 2]
This Phase 2 trial evaluated sirolimus, tacrolimus, and antithymocyte globulin to prevent graft-versus-host disease in patients with hematol…
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CLINICAL_TRIALS trial_result · 2017-05-30Clinical Trial Update: Reduced-Intensity Busulfan and Fludarabine With or Without Antithymocyte Globulin Followed by Donor Stem Cell Transplant in Treating Patients With Hematologic Cancer or Other Disease [Phase 2]
Phase 2 trial evaluating reduced-intensity conditioning with busulfan and fludarabine, with or without antithymocyte globulin, followed by d…
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CLINICAL_TRIALS trial_result · 2017-04-11Clinical Trial Update: Rasburicase in Preventing Graft-Versus-Host Disease in Patients With Hematologic Cancer or Other Disease Undergoing Donor Stem Cell Transplant [Phase 1]
A Phase 1 trial evaluating rasburicase to prevent graft-versus-host disease in patients undergoing donor stem cell transplantation; the stud…
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CLINICAL_TRIALS trial_result · 2017-02-27Clinical Trial Update: A Study of Anagrelide Controlled Release (GALE-401) in Patients With High Platelet Counts Due to Bone Marrow Disorders [Phase 2]
Phase 2 study of anagrelide controlled release (GALE-401) for high platelet counts due to bone marrow disorders has completed.
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CLINICAL_TRIALS trial_result · 2017-02-23Clinical Trial Update: Magnetic Resonance Imaging (MRI) Assessments of the Heart and Liver Iron Load in Patients With Transfusion Induced Iron Overload [Phase 4]
Novartis-sponsored Phase 4 trial assessing heart and liver iron load by MRI in patients with transfusion-related iron overload; the study st…
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CLINICAL_TRIALS trial_result · 2017-02-03Clinical Trial Update: Lactobacillus in Preventing Infection in Patients Undergoing a Donor Stem Cell Transplant for Hematologic Cancer or Myelodysplastic Syndrome [NA]
This clinical trial update indicates the Lactobacillus probiotic study intended to prevent infection in patients undergoing donor stem cell …