Myelodysplastic Syndrome
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2024-07-31Clinical Trial Update: Cytogenetic Studies in Acute Leukemia and Multiple Myeloma
Update on cytogenetic studies in acute leukemia and multiple myeloma; the trial is currently active but not recruiting.
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CLINICAL_TRIALS trial_result · 2024-07-29Clinical Trial Update: Study of Luspatercept for the Treatment of Anemia in Patients With Myelodysplastic Syndrome (MDS) (MK-6143-001) [Phase 2]
This clinical trial update reports the Phase 2 study of luspatercept for anemia in patients with myelodysplastic syndrome (MDS); the trial h…
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CLINICAL_TRIALS trial_result · 2024-07-23Clinical Trial Update: Azacitidine With or Without Nivolumab or Midostaurin, or Decitabine and Cytarabine Alone in Treating Older Patients With Newly Diagnosed Acute Myeloid Leukemia or High-Risk Myelodysplastic Syndrome [Phase 2, Phase 3]
This clinical trial update reports results from Phase 2 and Phase 3 studies evaluating azacitidine with or without nivolumab or midostaurin,…
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CLINICAL_TRIALS trial_result · 2024-07-17Clinical Trial Update: Tipifarnib in Subjects With Chronic Myelomonocytic Leukemia, Other MDS/MPN, and Acute Myeloid Leukemia [Phase 2]
This Phase 2 trial evaluated tipifarnib in patients with chronic myelomonocytic leukemia and other myelodysplastic/myeloproliferative neopla…
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CLINICAL_TRIALS trial_result · 2024-07-16Clinical Trial Update: Reduced-Intensity Conditioning (RIC) and Myeloablative Conditioning (MAC) for HSCT in AML/MDS [Phase 2]
Phase 2 clinical trial update comparing reduced-intensity conditioning and myeloablative conditioning for hematopoietic stem cell transplant…
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CLINICAL_TRIALS research · 2024-07-10Clinical Trial Update: Study of NEROFE, a Novel Hormone-Peptide in Adult Patients With Advanced MDS and AML [Phase 1]
Phase 1 clinical trial update for NEROFE, a novel hormone-peptide, in adults with advanced myelodysplastic syndrome and acute myeloid leukem…
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CLINICAL_TRIALS trial_result · 2024-06-25Clinical Trial Update: A Study Investigating the Safety, Tolerability and Efficacy of ASP7517 in Subjects With Relapsed/Refractory Acute Myeloid Leukemia (AML) and Relapsed/Refractory Higher Risk Myelodysplastic Syndrome (MDS) [Phase 1, Phase 2]
The document reports the completion and posting of results for a Phase 1/2 study evaluating ASP7517 for safety, tolerability, and preliminar…
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CLINICAL_TRIALS trial_result · 2024-06-11Clinical Trial Update: A Study of Sabatolimab in Combination With Azacitidine and Venetoclax in High or Very High Risk MDS Participants [Phase 2]
Phase 2 study of sabatolimab in combination with azacitidine and venetoclax in high- or very high-risk myelodysplastic syndrome was terminat…
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CLINICAL_TRIALS research · 2024-06-04Clinical Trial Update: CD34+ (Malignant) Stem Cell Selection for Patients Receiving Allogenic Stem Cell Transplant [Phase 1, Phase 2]
This clinical trial update examines using CD34+ malignant stem cell selection for patients receiving allogeneic stem cell transplants in Pha…
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CLINICAL_TRIALS research · 2024-05-08Clinical Trial Update: Pilot Study of CC 486 (Oral Azacitidine) Plus BSC as Maintenance After sc Azacitidine in Elderly HR-IPSS-R MDS Patients [Phase 2]
Pilot Phase 2 study evaluating CC-486 (oral azacitidine) plus best supportive care as maintenance after subcutaneous azacitidine in elderly …
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CLINICAL_TRIALS trial_result · 2024-04-29Clinical Trial Update: Study of KHK2823 in Patients With Acute Myeloid Leukemia (AML) and Myelodysplastic Syndrome (MDS) [Phase 1]
Phase 1 study of KHK2823 in Acute myeloid leukemia and myelodysplastic syndrome was terminated.
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CLINICAL_TRIALS trial_result · 2024-04-10Clinical Trial Update: Innate Donor Effector Allogeneic Lymphocyte Infusion After Stem Cell Transplantation: the IDEAL Trial [Phase 2, Phase 3]
Clinical trial update for IDEAL trial evaluating innate donor effector allogeneic lymphocyte infusion after stem cell transplantation in AML…
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CLINICAL_TRIALS trial_result · 2024-04-02Clinical Trial Update: Fludarabine Phosphate, Cyclophosphamide, Total Body Irradiation, and Donor Stem Cell Transplant in Treating Patients With Blood Cancer [Phase 2]
Phase 2 study evaluating a conditioning regimen of fludarabine phosphate, cyclophosphamide, and total body irradiation followed by donor ste…
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CLINICAL_TRIALS trial_result · 2024-03-12Clinical Trial Update: Selective Depletion of CD45RA+ T Cells From Allogeneic Peripheral Blood Stem Cell Grafts in Preventing GVHD in Children [Phase 2]
Phase 2 trial exploring selective depletion of CD45RA+ T cells from allogeneic stem cell grafts to prevent GVHD in children has completed wi…
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CLINICAL_TRIALS trial_result · 2024-02-28Clinical Trial Update: Quizartinib With Azacitidine or Cytarabine in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia or Myelodysplastic Syndrome [Phase 1, Phase 2]
Phase 1/2 trial evaluating quizartinib with azacitidine or cytarabine in relapsed or refractory acute myeloid leukemia and myelodysplastic s…
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CLINICAL_TRIALS trial_result · 2024-02-15Clinical Trial Update: Chemotherapy in Treating Patients With Myelodysplastic Syndrome Before Donor Stem Cell Transplant [Phase 2]
Phase 2 trial evaluating chemotherapy in patients with myelodysplastic syndromes prior to donor stem cell transplantation has completed with…
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CLINICAL_TRIALS trial_result · 2024-02-13Clinical Trial Update: IPA Targeted Adoptive Immunotherapy vs Adult Haplo-identical Cell Infusion During Induction of High Risk Leukemia [Phase 2]
Phase 2 trial evaluating IPA-targeted adoptive immunotherapy versus adult haplo-identical cell infusion for induction in high-risk leukemia;…
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CLINICAL_TRIALS trial_result · 2024-01-31Clinical Trial Update: CMV-MVA Triplex Vaccination of Stem Cell Donors in Preventing CMV Viremia in Participants With Allogeneic Transplant [Phase 1]
Phase 1 trial evaluating the CMV-MVA Triplex vaccine given to stem cell donors to prevent cytomegalovirus viremia in recipients of allogenei…
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CLINICAL_TRIALS trial_result · 2024-01-17Clinical Trial Update: Natural Killer Cells Before and After Donor Stem Cell Transplant in Treating Patients With Acute Myeloid Leukemia, Myelodysplastic Syndrome, or Chronic Myelogenous Leukemia [Phase 1, Phase 2]
Phase 1/2 trial evaluating natural killer cells as part of donor stem cell transplantation for various myeloid leukemias and myelodysplastic…
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CLINICAL_TRIALS trial_result · 2024-01-16Clinical Trial Update: Antigen-specific T Cell Therapy for AML or MDS Patients With Relapsed Disease After Allo-HCT [Phase 1, Phase 2]
A phase 1/2 clinical trial evaluating an antigen-specific T cell therapy for patients with acute myeloid leukemia or myelodysplastic syndrom…
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CLINICAL_TRIALS trial_result · 2024-01-12Clinical Trial Update: TAC/MTX vs. TAC/MMF/PTCY for Prevention of Graft-versus-Host Disease and Microbiome and Immune Reconstitution Study (BMT CTN 1703/1801) [Phase 3]
Phase 3 trial comparing TAC/MTX versus TAC/MMF/PTCY for graft-versus-host disease prevention and microbiome/immune reconstitution in patient…
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CLINICAL_TRIALS trial_result · 2023-12-18Clinical Trial Update: Continuation Study of B1371019(NCT03416179) and B1371012(NCT02367456) Evaluating Azacitidine With Or Without Glasdegib In Patients With Previously Untreated AML, MDS or CMML [Phase 3]
Phase 3 continuation study of azacitidine with or without glasdegib in untreated AML, MDS, or CMML; trial completed with results posted.
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CLINICAL_TRIALS trial_result · 2023-11-28Clinical Trial Update: Venetoclax Plus RIC Regimen Allo-HSCT for Elderly Patients With High-risk Myeloid Malignancies [Phase 2]
Phase 2 clinical trial evaluating venetoclax plus reduced-intensity conditioning allogeneic stem cell transplantation in elderly patients wi…
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CLINICAL_TRIALS trial_result · 2023-11-27Clinical Trial Update: Phase 3 Multicenter Randomized Double Blind Placebo Controlled Study With Antibacterial Prophylaxis in Azacitidine Treated MDS Patients [Phase 3]
Phase 3 multicenter randomized trial assessing antibacterial prophylaxis in azacitidine-treated myelodysplastic syndrome patients has comple…
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FDA approval · 2023-11-14FDA Approved: DEFERASIROX — Supplemental Application (Sun Pharmaceutical Industries, Inc.)
FDA approved a supplemental application for deferasirox submitted by Sun Pharmaceutical Industries, Inc., approving changes to the product l…