Myelodysplastic Myeloproliferative Neoplasm
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CLINICAL_TRIALS trial_result · 2026-06-04Clinical Trial Results: A Phase 1/2 Study of CPI-0610 With and Without Ruxolitinib in Patients With Hematologic and Myeloproliferative Malignancies [Phase 1, Phase 2]
Phase 1/2 clinical trial evaluating CPI-0610 with and without ruxolitinib in hematologic and myeloproliferative malignancies; study complete…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Azacitidine, Venetoclax, and Gilteritinib in Treating Patients With Recurrent/Refractory FLT3-Mutated Acute Myeloid Leukemia, Chronic Myelomonocytic Leukemia, or High-Risk Myelodysplastic Syndrome/Myeloproliferative Neoplasm [Phase 1, Phase 2]
This update describes a Phase 1/2 clinical trial evaluating a triplet regimen of azacitidine, venetoclax, and gilteritinib in patients with …
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: Phase I/II Study of Tagraxofusp in Combination With Decitabine for Patients With Myelomonocytic/Myeloproliferative Neoplasm and High Risk Myelodysplastic Syndromes [Phase 1, Phase 2]
An ongoing Phase I/II clinical trial evaluating Tagraxofusp in combination with Decitabine for patients with chronic myelomonocytic leukemia…
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: Study Investigating Patient-Reported Outcomes in Lower-risk MDS Patients
The study evaluating patient-reported outcomes in lower-risk myelodysplastic syndrome patients is currently active but not recruiting. Spons…
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CLINICAL_TRIALS trial_result · 2026-04-14Clinical Trial Update: Combination Chemotherapy (FLAG-Ida) With Pivekimab Sunirine (PVEK [IMGN632]) for the Treatment of Newly Diagnosed Adverse Risk Acute Myeloid Leukemia and Other High-Grade Myeloid Neoplasms [Phase 1]
Phase 1 study evaluating FLAG-Ida chemotherapy plus pivekimab sunirine (IMGN632) for newly diagnosed adverse-risk acute myeloid leukemia and…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Venetoclax in Combination With ASTX727 for the Treatment of Chronic Myelomonocytic Leukemia and Other Myelodysplastic Syndrome/Myeloproliferative Neoplasm [Phase 2]
Clinical trial update of a Phase 2 study evaluating venetoclax in combination with ASTX727 (oral decitabine/cedazuridine) for chronic myelom…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: A Randomized Study of ASTX727 With or Without Iadademstat in Advanced Myeloproliferative Neoplasms (MPNs) [Phase 2]
A Phase 2 randomized trial evaluating ASTX727 with or without iadademstat in advanced myeloproliferative neoplasms, currently recruiting.
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CLINICAL_TRIALS research · 2026-04-03Clinical Trial Update: A Telehealth Advance Care Planning Intervention [NA]
An ongoing clinical trial at the University of Rochester is evaluating a telehealth advance care planning intervention for myeloid malignanc…
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CLINICAL_TRIALS research · 2026-03-25Clinical Trial Update: Acquired Pyruvate Kinase Deficiency In Clonal Myeloid Neoplasms
This clinical trial update discusses a study of acquired pyruvate kinase deficiency in clonal myeloid neoplasms. The trial is currently acti…
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CLINICAL_TRIALS research · 2026-03-16Clinical Trial Update: Decitabine With Ruxolitinib, Fedratinib or Pacritinib for the Treatment of Accelerated/Blast Phase Myeloproliferative Neoplasms [Phase 2]
A Phase 2 clinical trial evaluating decitabine in combination with JAK inhibitors (ruxolitinib, fedratinib, or pacritinib) for accelerated o…
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CLINICAL_TRIALS research · 2026-03-13Clinical Trial Update: Axatilimab With or Without Azacitidine for the Treatment of Patients With Advanced Phase Myeloproliferative Neoplasms, Myeloproliferative Neoplasm/Myelodysplastic Syndrome Overlap or High Risk Chronic Myelomonocytic Leukemia [Phase 1, Phase 2]
Clinical trial update on Axatilimab with or without Azacitidine for advanced myeloproliferative neoplasms, including MDS/MPN overlap and hig…
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CLINICAL_TRIALS research · 2026-03-13Clinical Trial Update: Phase Ib Study of CD33 FPBMC in Patients With MRD+ AML or MDS [Phase 1]
This clinical trial update notes a Phase 1 study of CD33 FPBMC in patients with measurable residual disease positive acute myeloid leukemia …
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CLINICAL_TRIALS research · 2026-03-13Clinical Trial Update: Ropeginterferon Alfa-2b for the Treatment of Myelodysplastic Syndrome/Myeloproliferative Neoplasm Overlap Syndromes and Chronic Myelomonocytic Leukemia [Phase 2]
This clinical trial update describes a Phase 2 study of Ropeginterferon alfa-2b for treating myelodysplastic/myeloproliferative neoplasm ove…
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CLINICAL_TRIALS trial_result · 2026-03-02Clinical Trial Update: Edetate Calcium Disodium or Succimer in Treating Patients With Acute Myeloid Leukemia or Myelodysplastic Syndrome Undergoing Chemotherapy [Phase 1]
This clinical trial update describes a Phase 1 study of edetate calcium disodium or succimer in patients with acute myeloid leukemia or myel…
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CLINICAL_TRIALS research · 2026-02-23Clinical Trial Update: Onvansertib for the Treatment of Recurrent or Refractory Chronic Myelomonocytic Leukemia and Myelodysplastic Syndrome/MPN Overlap Neoplasms [Phase 1]
This clinical trial update notes a Phase 1 study of Onvansertib for recurrent or refractory chronic myelomonocytic leukemia and myelodysplas…
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CLINICAL_TRIALS research · 2025-04-04Clinical Trial Update: Hyperbaric Oxygen Therapy and Allogeneic Peripheral Blood Stem Cell (PBSC) Transplant [EARLY_Phase 1]
An early-phase 1 clinical trial is evaluating hyperbaric oxygen therapy in combination with allogeneic peripheral blood stem cell transplant…
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CLINICAL_TRIALS trial_result · 2024-07-17Clinical Trial Update: Tipifarnib in Subjects With Chronic Myelomonocytic Leukemia, Other MDS/MPN, and Acute Myeloid Leukemia [Phase 2]
This Phase 2 trial evaluated tipifarnib in patients with chronic myelomonocytic leukemia and other myelodysplastic/myeloproliferative neopla…
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CLINICAL_TRIALS trial_result · 2024-04-02Clinical Trial Update: Topotecan Hydrochloride and Carboplatin With or Without Veliparib in Treating Advanced Myeloproliferative Disorders and Acute Myeloid Leukemia or Chronic Myelomonocytic Leukemia [Phase 2]
Phase 2 trial update evaluating topotecan hydrochloride and carboplatin with or without veliparib for advanced myeloproliferative disorders …
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CLINICAL_TRIALS trial_result · 2024-01-31Clinical Trial Update: CMV-MVA Triplex Vaccination of Stem Cell Donors in Preventing CMV Viremia in Participants With Allogeneic Transplant [Phase 1]
Phase 1 trial evaluating the CMV-MVA Triplex vaccine given to stem cell donors to prevent cytomegalovirus viremia in recipients of allogenei…
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CLINICAL_TRIALS trial_result · 2023-06-06Clinical Trial Update: Sotatercept in Treating Patients With Myeloproliferative Neoplasm-Associated Myelofibrosis or Anemia [Phase 2]
Phase 2 trial of sotatercept in patients with myeloproliferative neoplasm-associated myelofibrosis or anemia has completed with results post…
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CLINICAL_TRIALS trial_result · 2022-08-15Clinical Trial Update: Ruxolitinib Phosphate and Decitabine in Treating Patients With Relapsed or Refractory or Post Myeloproliferative Acute Myeloid Leukemia [Phase 1, Phase 2]
Phase 1/2 study evaluating the combination of ruxolitinib phosphate and decitabine in patients with relapsed or refractory or post-myeloprol…
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CLINICAL_TRIALS trial_result · 2019-11-22Clinical Trial Update: Donor Atorvastatin Treatment in Preventing Severe Acute GVHD After Nonmyeloablative Peripheral Blood Stem Cell Transplant in Patients With Hematological Malignancies [Phase 2]
Phase 2 clinical trial assessing donor atorvastatin to prevent severe acute GVHD after nonmyeloablative peripheral blood stem cell transplan…
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CLINICAL_TRIALS trial_result · 2017-05-04Clinical Trial Update: Pentostatin and Lymphocyte Infusion in Preventing Graft Rejection in Patients Who Have Undergone Donor Stem Cell Transplant [Phase 2]
Phase 2 clinical trial evaluating pentostatin and lymphocyte infusion to prevent graft rejection after donor stem cell transplantation—compl…
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CLINICAL_TRIALS trial_result · 2015-09-15Clinical Trial Update: Tacrolimus and Mycophenolate Mofetil With or Without Sirolimus in Preventing Acute Graft-Versus-Host Disease in Patients Who Are Undergoing Donor Stem Cell Transplant for Hematologic Cancer [Phase 2]
Phase 2 clinical trial evaluating tacrolimus and mycophenolate mofetil with or without sirolimus to prevent acute graft-versus-host disease …
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CLINICAL_TRIALS trial_result · 2012-09-06Clinical Trial Update: Opioid Titration Order Sheet or Standard Care in Treating Patients With Cancer Pain [Phase 3]
Phase 3 clinical trial evaluating an opioid titration order sheet versus standard care for cancer-related pain; the study is completed with …