Muscle-invasive Bladder Cancer
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2025-11-21Clinical Trial Update: Interest of Late Images for the Assessment of Extensions in 18FGD PET-CT of Muscle-Invasive Bladder Cancers [NA]
A recruiting clinical trial evaluating whether late 18F-FDG PET-CT imaging improves assessment of tumor extensions in muscle-invasive bladde…
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CLINICAL_TRIALS research · 2025-11-20Clinical Trial Update: Home Intravenous Fluid Infusion After Undergoing Radical Cystectomy [NA]
Clinical trial entry from Johns Hopkins University recruiting to study home intravenous fluid infusion after radical cystectomy for bladder …
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CLINICAL_TRIALS research · 2025-11-18Clinical Trial Update: Atezolizumab After Chemo-radiotherapy for MIBC Patients Not Eligible for Radical Cystectomy [Phase 2]
Phase 2 study of atezolizumab after chemo-radiotherapy for muscle-invasive bladder cancer patients who are not eligible for radical cystecto…
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CLINICAL_TRIALS research · 2025-11-17Clinical Trial Update: Prophylactic Antibiotics in Cystectomy With Diversion [EARLY_Phase 1]
This early-phase 1 trial evaluates prophylactic antibiotics around radical cystectomy with diversion for muscle-invasive bladder cancer and …
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CLINICAL_TRIALS trial_result · 2025-10-31Clinical Trial Update: Avelumab and Radiation in Muscle-Invasive Bladder Cancer [Phase 2]
A Phase 2 trial evaluating avelumab with radiation for muscle-invasive bladder cancer was terminated, and results have been posted.
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CLINICAL_TRIALS trial_result · 2025-10-31Clinical Trial Update: Increasing Pre-Surgical Identification of Muscle Invasive Tumor Evaluations Prior to Planned Cystectomy (INSITE)
Clinical trial INSITE investigates pre-surgical identification of muscle-invasive tumor involvement in patients with urothelial carcinoma sc…
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CLINICAL_TRIALS withdrawal · 2025-10-21Clinical Trial Update: Testing Anti-Cancer Drugs Erdafitinib With or Without Atezolizumab in Patients With Localized Bladder Cancer Not Able to Receive Cisplatin Chemotherapy, NERA Trial [Phase 2]
The NERA trial, a Phase 2 study of erdafitinib with or without atezolizumab in localized bladder cancer patients ineligible for cisplatin ch…
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CLINICAL_TRIALS research · 2025-10-20Clinical Trial Update: A Study to Assess Safety, Tolerability and Imaging Characteristics of [68Ga]Ga-DPI-4452 and to Assess Safety, Tolerability, and Efficacy of [177Lu]Lu-DPI-4452 in Participants With Unresectable Locally Advanced or Metastatic Solid Tumors [Phase 1, Phase 2]
A Phase 1/2 clinical trial update describing safety, tolerability, and imaging with [68Ga]Ga-DPI-4452 and safety, tolerability, and efficacy…
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CLINICAL_TRIALS trial_result · 2025-10-10Clinical Trial Update: A Phase II Trial Evaluating an Organ-conserving Strategy by Radiochemotherapy for Muscle-infiltrative Bladder Cancer [NA]
A Phase II trial evaluating an organ-conserving radiochemotherapy approach for muscle-invasive bladder cancer has been terminated, with resu…
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CLINICAL_TRIALS trial_result · 2025-10-07Clinical Trial Update: Pembrolizumab (MK3475), Gemcitabine, and Concurrent Hypofractionated Radiation Therapy for Muscle-Invasive Urothelial Cancer of the Bladder [Phase 2]
Phase 2 clinical trial update evaluating pembrolizumab with gemcitabine and concurrent hypofractionated radiation therapy for muscle-invasiv…
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CLINICAL_TRIALS research · 2025-10-02Clinical Trial Update: Effect of Neoadjuvant Chemotherapy on MRI Accuracy Before Cystectomy [NA]
A clinical trial from Assiut University is evaluating whether neoadjuvant chemotherapy affects the accuracy of MRI in staging before cystect…
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CLINICAL_TRIALS research · 2025-10-02Clinical Trial Update: Early Prediction of Neoadjuvant Chemotherapy Response in Bladder Cancer Using Quantitative Multiparametric MRI
This clinical trial aims to predict early response to neoadjuvant chemotherapy in muscle-invasive bladder cancer using quantitative multipar…
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CLINICAL_TRIALS research · 2025-10-01Clinical Trial Update: Vedisertib (RC48/ADC) Combined With Toripalimab in Bladder-preserving Treatment [Phase 2]
Phase 2 trial protocol evaluating Vedisertib (RC48/ADC) in combination with Toripalimab for bladder-preserving treatment in muscle-invasive …
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CLINICAL_TRIALS research · 2025-09-30Clinical Trial Update: Survival Benefits of Neoadjuvant Systemic Chemotherapy in Muscle Invasive Bladder Cancer
This clinical trial update describes planned research on whether neoadjuvant systemic chemotherapy improves survival in muscle-invasive blad…
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CLINICAL_TRIALS trial_result · 2025-09-18Clinical Trial Update: Pembrolizumab and Combination Chemotherapy Before Surgery for the Treatment of Muscle-Invasive Bladder Cancer [Phase 2]
Phase 2 study evaluating pembrolizumab in combination with neoadjuvant chemotherapy before cystectomy for muscle-invasive bladder cancer; re…
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CLINICAL_TRIALS trial_result · 2025-09-18Clinical Trial Update: Role of FDG-PET CT in the Management of Muscle Invasive Bladder Cancer
This clinical trial evaluates the role of FDG-PET CT in managing muscle-invasive bladder cancer. The study is completed and results have bee…
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CLINICAL_TRIALS research · 2025-09-15Clinical Trial Update: Enfortumab Vedotin and Stereotactic Radiation for Localized, Cisplatin Ineligible Muscle Invasive Bladder Cancer [Phase 1, Phase 2]
A Phase 1/2 trial is evaluating enfortumab vedotin in combination with stereotactic radiation for localized, cisplatin-ineligible muscle-inv…
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CLINICAL_TRIALS research · 2025-09-03Clinical Trial Update: Efficacy and Safety of Two Bladder-preserving Treatment Durations With Disitamab Vedotin Plus Toripalimab Combination in Her2-expressing Muscle-invasive Bladder Cancer: A Phase II, Open-Label, Randomized Clinical Trial [Phase 2]
This Phase II, open-label, randomized trial assesses two bladder-preserving durations of Disitamab Vedotin plus Toripalimab in HER2-expressi…
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CLINICAL_TRIALS research · 2025-09-02Clinical Trial Update: Gemcitabine/Cisplatin Plus Cemiplimab With or Without Fianlimab in Localized Muscle-invasive Bladder Cancer (NeoSTOP-IT) [Phase 2]
Phase 2 trial NeoSTOP-IT evaluating gemcitabine/cisplatin plus cemiplimab with or without fianlimab in localized muscle-invasive bladder can…
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CLINICAL_TRIALS trial_result · 2025-08-29Clinical Trial Update: Pembrolizumab and EV With Radiation Therapy for MIBC Patients (PEVRAD) [Phase 2]
A Phase 2 trial at Kyoto University Hospital is evaluating pembrolizumab with enfortumab vedotin and radiation therapy for muscle-invasive b…
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CLINICAL_TRIALS research · 2025-08-28Clinical Trial Update: Perioperative Pembrolizumab (MK-3475) Plus Neoadjuvant Chemotherapy Versus Perioperative Placebo Plus Neoadjuvant Chemotherapy for Cisplatin-eligible Muscle-invasive Bladder Cancer (MIBC) (MK-3475-866/KEYNOTE-866) [Phase 3]
A Phase 3 trial update evaluating perioperative pembrolizumab plus neoadjuvant chemotherapy versus perioperative placebo with neoadjuvant ch…
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CLINICAL_TRIALS research · 2025-08-28Clinical Trial Update: Perioperative Pembrolizumab (MK-3475) Plus Cystectomy or Perioperative Pembrolizumab Plus Enfortumab Vedotin Plus Cystectomy Versus Cystectomy Alone in Participants Who Are Cisplatin-ineligible or Decline Cisplatin With Muscle-invasive Bladder Cancer (MK-3475-905/KEYNOTE-905/EV-303) [Phase 3]
Phase 3 clinical trial MK-3475-905/KEYNOTE-905/EV-303 is testing perioperative pembrolizumab with cystectomy, with or without enfortumab ved…
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CLINICAL_TRIALS research · 2025-08-26Clinical Trial Update: A Clinical Study Evaluating the Efficacy and Safety of Disitamab Vedotin Combined With PD-1 Inhibitor and Radiotherapy as Bladder-preserving Therapy in Patients With Localized HER2-high Expressing Muscle-invasive Bladder Urothelial Carcinoma Following Maximal Transurethral Resection [Phase 2]
Phase 2 trial assessing Disitamab Vedotin combined with a PD-1 inhibitor and radiotherapy as a bladder-preserving treatment for localized HE…
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CLINICAL_TRIALS research · 2025-08-24Clinical Trial Update: MRI-Guided Bladder Preservation Program For Patients With Muscle Invasive Bladder Cancer [NA]
This entry describes an MRI-guided bladder preservation trial for muscle-invasive bladder cancer, which is currently not yet recruiting.
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CLINICAL_TRIALS research · 2025-08-14Clinical Trial Update: Pan-tumor MRD Study
Paradigm Health's Pan-tumor MRD study (NCT06605404) is currently recruiting across several solid tumor indications including bladder, esopha…