Muscle-invasive Bladder Cancer
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2026-06-17Clinical Trial Update: Testing MK-3475 (Pembrolizumab) After Surgery for Localized Muscle-Invasive Bladder Cancer and Locally Advanced Urothelial Cancer [Phase 3]
Phase 3 clinical trial investigating pembrolizumab (MK-3475) after surgery for localized muscle-invasive bladder cancer and locally advanced…
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CLINICAL_TRIALS trial_result · 2026-06-05Clinical Trial Update: A Study of TAR-200 in Combination With Cetrelimab Versus Concurrent Chemoradiotherapy in Participants With Muscle-invasive Bladder Cancer (MIBC) of the Bladder [Phase 3]
Phase 3 trial comparing TAR-200 plus cetrelimab versus concurrent chemoradiotherapy in muscle-invasive bladder cancer is active but not recr…
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CLINICAL_TRIALS trial_result · 2026-06-04Clinical Trial Update: Treatment Combination of Durvalumab, Tremelimumab and Enfortumab Vedotin or Durvalumab and Enfortumab Vedotin in Patients With Muscle Invasive Bladder Cancer Ineligible to Cisplatin or Who Refuse Cisplatin [Phase 3]
Phase 3 trial investigating durvalumab with tremelimumab and enfortumab vedotin or durvalumab with enfortumab vedotin for muscle invasive bl…
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CLINICAL_TRIALS trial_result · 2026-04-28Clinical Trial Update: Efficacy and Safety of Pembrolizumab (MK-3475) in Combination With Chemoradiotherapy (CRT) Versus CRT Alone in Muscle-invasive Bladder Cancer (MIBC) (MK-3475-992/KEYNOTE-992) [Phase 3]
Phase 3 trial evaluating pembrolizumab with chemoradiotherapy versus chemoradiotherapy alone in muscle-invasive bladder cancer.
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CLINICAL_TRIALS trial_result · 2026-04-27Clinical Trial Update: Sacituzumab Govitecan Before Radical Cystectomy for the Treatment of Non-Urothelial Muscle Invasive Bladder Cancer [Phase 2]
Phase 2 trial update for sacituzumab govitecan used before radical cystectomy in muscle invasive bladder cancer; the study is terminated wit…
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CLINICAL_TRIALS trial_result · 2026-04-13Clinical Trial Update: Gemcitabine and Cisplatin Without Cystectomy for Patients With Muscle Invasive Bladder Urothelial Cancer and Select Genetic Alterations [Phase 2]
Phase 2 clinical trial evaluating gemcitabine and cisplatin without cystectomy for muscle-invasive bladder cancer with selected genetic alte…
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CLINICAL_TRIALS trial_result · 2026-03-27Clinical Trial Update: Sacituzumab Govitecan, Preceding Radical Cystectomy, in Treating Patients With Muscle-invasive Bladder Cancer [Phase 2]
Phase 2 study evaluating sacituzumab govitecan as neoadjuvant therapy before radical cystectomy for muscle-invasive bladder cancer has compl…
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CLINICAL_TRIALS trial_result · 2026-03-13Clinical Trial Update: Adaptive RADiation Therapy With Concurrent Sacituzumab Govitecan (SG) for Muscle Invasive Bladder Cancer [Phase 1]
A phase 1 clinical trial is evaluating adaptive radiotherapy with Sacituzumab Govitecan for localized or muscle-invasive bladder cancer. The…
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CLINICAL_TRIALS trial_result · 2026-02-27Clinical Trial Update: Complete Local Response to Neoadjuvant Chemotherapy in Patients With Muscle Invasive Bladder Cancer Evaluated by 15O-H2O PET/MR [NA]
A completed clinical trial reports complete local response to neoadjuvant chemotherapy in muscle-invasive bladder cancer. The response was e…
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CLINICAL_TRIALS trial_result · 2026-02-27Clinical Trial Update: Study of CG0070 Combined With Nivolumab in Cisplatin Ineligible Patients With MIBC [Phase 1]
A completed Phase 1 study evaluating CG0070 in combination with nivolumab in cisplatin-ineligible muscle-invasive bladder cancer.
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CLINICAL_TRIALS trial_result · 2026-02-05Clinical Trial Update: Perioperative Enfortumab Vedotin (EV) Plus Pembrolizumab (MK-3475) Versus Neoadjuvant Chemotherapy for Cisplatin-Eligible Muscle Invasive Bladder Cancer (MIBC) (MK-3475-B15/ KEYNOTE-B15 / EV-304) [Phase 3]
Phase 3 trial MK-3475-B15/KEYNOTE-B15/EV-304 evaluating perioperative enfortumab vedotin plus pembrolizumab versus neoadjuvant chemotherapy …
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CLINICAL_TRIALS trial_result · 2025-11-28Clinical Trial Update: ctDNA in Subjects With Muscle-invasive Bladder Cancer Treated With Trimodality Therapy
Clinical trial update reporting ctDNA findings in patients with muscle-invasive bladder cancer treated with trimodality therapy.
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CLINICAL_TRIALS trial_result · 2025-10-31Clinical Trial Update: Avelumab and Radiation in Muscle-Invasive Bladder Cancer [Phase 2]
A Phase 2 trial evaluating avelumab with radiation for muscle-invasive bladder cancer was terminated, and results have been posted.
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CLINICAL_TRIALS trial_result · 2025-10-31Clinical Trial Update: Increasing Pre-Surgical Identification of Muscle Invasive Tumor Evaluations Prior to Planned Cystectomy (INSITE)
Clinical trial INSITE investigates pre-surgical identification of muscle-invasive tumor involvement in patients with urothelial carcinoma sc…
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CLINICAL_TRIALS trial_result · 2025-10-10Clinical Trial Update: A Phase II Trial Evaluating an Organ-conserving Strategy by Radiochemotherapy for Muscle-infiltrative Bladder Cancer [NA]
A Phase II trial evaluating an organ-conserving radiochemotherapy approach for muscle-invasive bladder cancer has been terminated, with resu…
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CLINICAL_TRIALS trial_result · 2025-10-07Clinical Trial Update: Pembrolizumab (MK3475), Gemcitabine, and Concurrent Hypofractionated Radiation Therapy for Muscle-Invasive Urothelial Cancer of the Bladder [Phase 2]
Phase 2 clinical trial update evaluating pembrolizumab with gemcitabine and concurrent hypofractionated radiation therapy for muscle-invasiv…
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CLINICAL_TRIALS trial_result · 2025-09-18Clinical Trial Update: Pembrolizumab and Combination Chemotherapy Before Surgery for the Treatment of Muscle-Invasive Bladder Cancer [Phase 2]
Phase 2 study evaluating pembrolizumab in combination with neoadjuvant chemotherapy before cystectomy for muscle-invasive bladder cancer; re…
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CLINICAL_TRIALS trial_result · 2025-09-18Clinical Trial Update: Role of FDG-PET CT in the Management of Muscle Invasive Bladder Cancer
This clinical trial evaluates the role of FDG-PET CT in managing muscle-invasive bladder cancer. The study is completed and results have bee…
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CLINICAL_TRIALS trial_result · 2025-08-29Clinical Trial Update: Pembrolizumab and EV With Radiation Therapy for MIBC Patients (PEVRAD) [Phase 2]
A Phase 2 trial at Kyoto University Hospital is evaluating pembrolizumab with enfortumab vedotin and radiation therapy for muscle-invasive b…
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CLINICAL_TRIALS trial_result · 2025-07-03Clinical Trial Update: Durvalumab+ Gemcitabine/Cisplatin (Neoadjuvant Treatment) and Durvalumab (Adjuvant Treatment) in Patients With MIBC [Phase 3]
Phase 3 trial evaluating neoadjuvant durvalumab with gemcitabine/cisplatin and adjuvant durvalumab for muscle-invasive bladder cancer is act…
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CLINICAL_TRIALS trial_result · 2025-05-31Clinical Trial Update: Deep Learning Radiomics Model for Predicting Post-cystectomy Outcome in Muscle Invasive Bladder Cancer
A clinical trial is evaluating a deep learning radiomics model to predict outcomes after cystectomy in patients with muscle-invasive bladder…
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CLINICAL_TRIALS trial_result · 2025-05-09Clinical Trial Update: AURORAX-0093A: Glycosaminoglycan Profiling for Prognostication of Muscle-invasive Bladder Cancer - a Pilot Study
This clinical trial update reports on a pilot study evaluating glycosaminoglycan profiling as a prognostic tool for muscle-invasive bladder …
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CLINICAL_TRIALS trial_result · 2025-04-11Clinical Trial Update: Brazilian Reality of Urinary Bladder Cancers - BRA-BLADDER
AstraZeneca-sponsored BRA-BLADDER study evaluating bladder cancer in Brazil has completed, examining urothelial carcinoma across non-muscle …
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CLINICAL_TRIALS trial_result · 2025-02-26Clinical Trial Update: Avelumab as Neoadjuvant Therapy in Subjects With Urothelial Muscle Invasive Bladder Cancers (AURA Trial) [Phase 2]
Phase 2 trial evaluating avelumab as neoadjuvant therapy for non-metastatic muscle-invasive bladder cancer has completed.
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CLINICAL_TRIALS trial_result · 2025-02-04Clinical Trial Update: A Novel Pathway to Detect Muscle-invasive Bladder Cancer Based on Integrated Clinical Features and VI-RADS Score on MRI
This clinical trial update reports on a completed study evaluating a new pathway to detect muscle-invasive bladder cancer using integrated c…