Muscle-invasive Bladder Cancer
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2026-02-27Clinical Trial Update: Complete Local Response to Neoadjuvant Chemotherapy in Patients With Muscle Invasive Bladder Cancer Evaluated by 15O-H2O PET/MR [NA]
A completed clinical trial reports complete local response to neoadjuvant chemotherapy in muscle-invasive bladder cancer. The response was e…
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CLINICAL_TRIALS trial_result · 2026-02-27Clinical Trial Update: Study of CG0070 Combined With Nivolumab in Cisplatin Ineligible Patients With MIBC [Phase 1]
A completed Phase 1 study evaluating CG0070 in combination with nivolumab in cisplatin-ineligible muscle-invasive bladder cancer.
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CLINICAL_TRIALS research · 2026-02-27Clinical Trial Update: Sacituzumab Govitecan Before Radical Cystectomy for the Treatment of Non-Urothelial Muscle Invasive Bladder Cancer [Phase 2]
Phase 2 clinical trial evaluating sacituzumab govitecan before radical cystectomy for non-urothelial muscle invasive bladder cancer; recruit…
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CLINICAL_TRIALS research · 2026-02-27Clinical Trial Update: Remodeling of MHC-related Immune Microenvironment in MIBC After Neoadjuvant Therapy
This clinical trial explores how neoadjuvant therapy reshapes the MHC-related immune microenvironment in muscle-invasive bladder cancer.
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CLINICAL_TRIALS research · 2026-02-23Clinical Trial Update: Enfortumab Vedotin Plus Pembrolizumab With Selective Bladder Sparing for Treatment of Muscle-invasive Bladder Cancer [Phase 2]
A Phase 2 clinical trial evaluating the combination of enfortumab vedotin and pembrolizumab with a selective bladder-sparing approach for mu…
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CLINICAL_TRIALS research · 2026-02-18Clinical Trial Update: Enfortumab Vedotin and Pembrolizumab Combined With Radiotherapy in Muscle Invasive Bladder Cancer [Phase 1, Phase 2]
This is a Phase 1/2 clinical trial evaluating enfortumab vedotin plus pembrolizumab with radiotherapy for muscle-invasive bladder cancer, cu…
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CLINICAL_TRIALS research · 2026-02-18Clinical Trial Update: Partial Cystectomy & Extended Pelvic Lymph Node Dissection With SOC Perioperative Systemic Therapy [Phase 2]
A Phase 2 clinical trial evaluating partial cystectomy with extended pelvic lymph node dissection and standard perioperative systemic therap…
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CLINICAL_TRIALS research · 2026-02-17Clinical Trial Update: Clinical Trial to Evaluate Post-Operative Outcomes of Ureteral Stent vs Ureteral Stent Free Radical Cystectomy [NA]
A clinical trial at Thomas Jefferson University is evaluating postoperative outcomes of ureteral stent use versus stent-free radical cystect…
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CLINICAL_TRIALS research · 2026-02-12Clinical Trial Update: Radical CystEctomy or RaDio-chEMotherapy as Preferred Treatment for invasivE blaDder Cancer [NA]
A clinical trial update describing a study comparing radical cystectomy versus radiochemotherapy as the preferred treatment approach for mus…
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CLINICAL_TRIALS trial_result · 2026-02-05Clinical Trial Update: Perioperative Enfortumab Vedotin (EV) Plus Pembrolizumab (MK-3475) Versus Neoadjuvant Chemotherapy for Cisplatin-Eligible Muscle Invasive Bladder Cancer (MIBC) (MK-3475-B15/ KEYNOTE-B15 / EV-304) [Phase 3]
Phase 3 trial MK-3475-B15/KEYNOTE-B15/EV-304 evaluating perioperative enfortumab vedotin plus pembrolizumab versus neoadjuvant chemotherapy …
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CLINICAL_TRIALS research · 2026-02-04Clinical Trial Update: Bladder Preservation for Patients With Muscle Invasive Bladder Cancer (MIBC) With Variant Histology [Phase 2]
Phase 2 clinical trial evaluating bladder-preserving approaches for muscle-invasive bladder cancer with variant histology; currently recruit…
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CLINICAL_TRIALS research · 2026-02-02Clinical Trial Update: Trimodality Therapy With/Out Durvalumab to Treat Patients With Muscle-Invasive Bladder Cancer [Phase 2]
A Phase 2 clinical trial from the Canadian Cancer Trials Group is evaluating trimodality therapy with or without durvalumab for muscle-invas…
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CLINICAL_TRIALS research · 2026-01-21Clinical Trial Update: Intravesical Recombinant BCG Followed by Perioperative Chemo-immunotherapy for Patients With MIBC [Phase 2]
A Phase 2 clinical trial update evaluating intravesical recombinant Bacillus Calmette-Guérin (BCG) followed by perioperative chemo-immunothe…
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CLINICAL_TRIALS research · 2026-01-15Clinical Trial Update: Sample Collection for Ongoing Research and Product Evaluation Study
Natera reports an ongoing study update focused on sample collection for ongoing research and product evaluation; the trial is currently recr…
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CLINICAL_TRIALS research · 2026-01-14Clinical Trial Update: Supporting Sexual Health in Bladder Cancer Patients: A Sequential Mixed-Methods Intervention Study [NA]
A sequential mixed-methods intervention trial to support sexual health in bladder cancer patients, currently recruiting.
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CLINICAL_TRIALS research · 2026-01-13Clinical Trial Update: Personalized Cancer Vaccine (PCV) Strategy in Patients With Solid Tumors and Molecular Residual Disease [Phase 1]
Phase 1 clinical trial update evaluating a Personalized Cancer Vaccine (PCV) strategy in patients with solid tumors, specifically muscle-inv…
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CLINICAL_TRIALS research · 2026-01-08Clinical Trial Update: Multi-parametric MRI in Patients Suspected for Muscle Invasive Bladder Cancer: a New Local Staging Paradigm [NA]
This clinical trial update describes a study evaluating multi-parametric MRI for local staging in patients suspected of muscle-invasive blad…
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CLINICAL_TRIALS research · 2026-01-07Clinical Trial Update: Adjuvant Nivolumab Following Chemo-Radiation in Localized Muscle-Invasive Bladder Cancer [Phase 2]
A phase 2 study evaluating nivolumab as adjuvant therapy after chemo-radiation in localized muscle-invasive bladder cancer; the trial is cur…
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CLINICAL_TRIALS research · 2025-12-29Clinical Trial Update: Open-Label, Randomised, Multi-Drug, Biomarker-Directed, Phase 1b Study in Pts w/ Muscle Invasive Bladder Cancer [Phase 1]
An open-label, randomized Phase 1b study evaluating a multi-drug, biomarker-directed approach in patients with muscle-invasive bladder cance…
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CLINICAL_TRIALS research · 2025-12-22Clinical Trial Update: Neoadjuvant Zanidatamab + Tislelizumab + Chemotherapy for Selective Bladder Preservation in HER2-Positive MIBC [Phase 2]
This clinical trial update describes a Phase 2 neoadjuvant study combining zanidatamab, tislelizumab, and chemotherapy to enable selective b…
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CLINICAL_TRIALS research · 2025-12-19Clinical Trial Update: Erdafitinib Monotherapy or in Combination With Cetrelimab in Muscle-invasive Bladder Cancer Patients With Fibroblast Growth Factor Receptor (FGFR ) Gene Alterations [Phase 2]
A Phase 2 trial is evaluating erdafitinib alone or in combination with cetrelimab for FGFR-altered muscle-invasive bladder cancer, currently…
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CLINICAL_TRIALS research · 2025-12-17Clinical Trial Update: Futibatinib in Combination With Durvalumab Prior to Cystectomy for the Treatment of Muscle-Invasive Bladder Cancer Patients Who Are Ineligible for Cisplatin-based Therapy [Phase 2]
Phase 2 trial evaluating futibatinib in combination with durvalumab prior to cystectomy for patients with muscle-invasive bladder cancer ine…
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CLINICAL_TRIALS research · 2025-12-11Clinical Trial Update: Neoadjuvant Immunotherapy Combined With the Anti-GDF-15 Antibody Visugromab to Treat Muscle Invasive Bladder Cancer [Phase 2]
This Phase 2 neoadjuvant trial evaluates Visugromab, an anti-GDF-15 antibody, in combination with immunotherapy for muscle-invasive bladder …
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CLINICAL_TRIALS research · 2025-12-01Clinical Trial Update: Treating Muscle-invasive Bladder Cancer With A Non-surgical Method Consisting of Anti-PD-1 Therapy and Chemoradiation [Phase 2]
Phase 2 trial evaluating a non-surgical treatment for muscle-invasive bladder cancer using anti-PD-1 therapy in combination with chemoradiat…
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CLINICAL_TRIALS trial_result · 2025-11-28Clinical Trial Update: ctDNA in Subjects With Muscle-invasive Bladder Cancer Treated With Trimodality Therapy
Clinical trial update reporting ctDNA findings in patients with muscle-invasive bladder cancer treated with trimodality therapy.