Melanoma
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CLINICAL_TRIALS withdrawal · 2018-05-09Clinical Trial Update: ML29255 Neoadjuvant Vemurafenib and Cobimetinib Melanoma [Phase 2]
A Phase 2 neoadjuvant trial of vemurafenib and cobimetinib for Stage IIIB-C melanoma has been withdrawn.
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CLINICAL_TRIALS withdrawal · 2018-05-04Clinical Trial Update: REO13 Melanoma With of Without GM-CSF [Phase 1, Phase 2]
The REO13 trial evaluating melanoma with or without GM-CSF (sargramostim) in Phase 1/2 has been withdrawn.
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CLINICAL_TRIALS withdrawal · 2018-04-09Clinical Trial Update: The Effectiveness of Nivolumab Monotherapy as First-Line Therapy in Adults With Advanced Melanoma in Germany
A clinical trial evaluating nivolumab monotherapy as first-line treatment for adults with advanced melanoma in Germany has been withdrawn.
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CLINICAL_TRIALS withdrawal · 2018-04-05Clinical Trial Update: Pembrolizumab and Imatinib in Patients With Locally Advanced/Metastatic Melanoma With c-KIT Mutation/Amplification [Phase 1, Phase 2]
This clinical trial update reports that the Phase 1/2 study of pembrolizumab in combination with imatinib for locally advanced or metastatic…
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EMA withdrawal · 2018-03-27EMA Application withdrawn: Balimek (binimetinib) — Pierre Fabre Médicament
The EMA withdrew the application for Balimek (binimetinib) by Pierre Fabre Médicament for melanoma.
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CLINICAL_TRIALS withdrawal · 2017-12-13Clinical Trial Update: Genistein in Treating Patients Undergoing External-Beam Radiation Therapy for Bone Metastases [Phase 1, Phase 2]
A Phase 1/2 clinical trial of genistein in patients undergoing external-beam radiation therapy for bone metastases was withdrawn.
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CLINICAL_TRIALS withdrawal · 2017-11-24Clinical Trial Update: Dose Escalation and Cohort Expansion of Safety and Tolerability Study of Intratumoral rAd.CD40L (ISF35) in Combination of Systemic Pembrolizumab in Patients With Refractory Metastatic Melanoma [Phase 1, Phase 2]
A Phase 1/2 trial evaluating intratumoral ISF35 (rAd.CD40L) in combination with pembrolizumab for refractory metastatic melanoma has been wi…
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CLINICAL_TRIALS withdrawal · 2017-08-24Clinical Trial Update: Low-dose Cyclophosphamide and Outpatient IV Interleukin-2 in Metastatic Melanoma [Phase 2]
Phase 2 trial of low-dose cyclophosphamide with outpatient IV interleukin-2 in metastatic melanoma has been withdrawn.
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CLINICAL_TRIALS withdrawal · 2017-08-15Clinical Trial Update: Access Study of Trametinib for Subjects With Advanced Unresectable (Stage IIIc) or Distant Metastatic (Stage IV) BRAF V600E/K Mutation Positive Cutaneous Melanoma
This trial update notes that the Access Study of trametinib in advanced unresectable or metastatic BRAF V600E/K-mutant cutaneous melanoma is…
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CLINICAL_TRIALS withdrawal · 2017-08-01Clinical Trial Update: A Study of Anti-PD-1 (Pembrolizumab) Therapy in Metastatic Melanoma (ADAPTeM) [Phase 2]
The ADAPTeM Phase 2 trial of pembrolizumab for metastatic melanoma has been withdrawn.
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CLINICAL_TRIALS withdrawal · 2017-07-27Clinical Trial Update: In Vivo Persistence of Adoptively-Transferred TIL Cultured With Akti in People With Metastatic Melanoma [Phase 1]
The Phase 1 trial of adoptively transferred tumor-infiltrating lymphocytes cultured with an Akt inhibitor for metastatic melanoma has been w…
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CLINICAL_TRIALS withdrawal · 2017-07-21Clinical Trial Update: Adoptive Therapy Using Antigen-Specific CD4 T-Cells [Phase 1]
A Phase 1 trial of adoptive therapy using antigen-specific CD4 T-cells for melanoma and sarcoma has been withdrawn.
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CLINICAL_TRIALS withdrawal · 2017-05-24Clinical Trial Update: Radiation Use During Vemurafenib Treatment [Phase 1]
A Phase I trial investigating the use of radiation during vemurafenib treatment for BRAFV600 mutation-associated Stage IV melanoma has been …
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CLINICAL_TRIALS withdrawal · 2017-02-01Clinical Trial Update: Impact of Obstructive SAS on Metastatic Potential of Cutaneous Melanoma [EARLY_Phase 1]
A phase 1 trial evaluating the impact of obstructive sleep apnea on metastatic potential in cutaneous melanoma has been withdrawn. The study…
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CLINICAL_TRIALS withdrawal · 2017-02-01Clinical Trial Update: A Phase II Trial of Sunitinib and Nivolumab for KIT-mutated Advanced Melanoma [Phase 2]
This document reports the withdrawal of a Phase II trial evaluating the combination of sunitinib and nivolumab for KIT-mutated advanced mela…
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CLINICAL_TRIALS withdrawal · 2016-12-07Clinical Trial Update: A Trial of CDX-1401 in Combination With Poly-ICLC and Pembrolizumab, in Previously Treated Advanced Solid Tumor Patients [Phase 1, Phase 2]
This Phase 1/Phase 2 trial evaluating CDX-1401 in combination with Poly-ICLC and pembrolizumab for previously treated advanced solid tumors …
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CLINICAL_TRIALS withdrawal · 2016-11-15Clinical Trial Update: Trial of Vemurafenib and Cobimetinib in Patients With Advanced BRAFV600 Mutant Melanoma [Phase 3]
Phase 3 trial investigating vemurafenib plus cobimetinib in advanced BRAFV600-mutant melanoma has been withdrawn.
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CLINICAL_TRIALS withdrawal · 2016-11-02Clinical Trial Update: A Pharmacokinetics Study to Investigate the Effect of Ketoconazole on Vemurafenib in Patients With BRAFV600 Mutation-Positive Metastatic Melanoma [Phase 1]
The Phase 1 pharmacokinetics study assessing the effect of ketoconazole on vemurafenib in BRAFV600 mutation–positive metastatic melanoma has…
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CLINICAL_TRIALS withdrawal · 2016-09-27Clinical Trial Update: Pharmacodynamics Study of MRX34, MicroRNA Liposomal Injection in Melanoma Patients With Biopsy Accessible Lesions [Phase 1, Phase 2]
Clinical trial update indicates the MRX34 microRNA liposomal injection study in melanoma has been withdrawn.
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CLINICAL_TRIALS withdrawal · 2016-07-27Clinical Trial Update: Collection of Cerebrospinal Fluid and Tumor Tissue in Subjects With Metastatic Melanoma and Controls
The study on collection of cerebrospinal fluid and tumor tissue in subjects with metastatic melanoma and controls has been withdrawn.
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CLINICAL_TRIALS withdrawal · 2016-05-09Clinical Trial Update: Biomarker Correlates of Hypoxia in Metastatic Melanoma [Phase 2]
The Phase 2 trial investigating biomarker correlates of hypoxia in metastatic melanoma has been withdrawn.
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CLINICAL_TRIALS withdrawal · 2016-04-21Clinical Trial Update: Combo of Abraxane, TMZ, Bevacizumab in Metastatic Melanoma With Brain Metastases [Phase 1, Phase 2]
The University of Arizona-sponsored Phase 1/2 trial of Abraxane plus temozolomide and bevacizumab for metastatic melanoma with brain metasta…
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CLINICAL_TRIALS withdrawal · 2016-01-25Clinical Trial Update: Pilot Study to Evaluate the Effects of a Vaccine (HSPPC-96) Combined With Ipilimumab in Patients With Advanced Melanoma [Phase 1, Phase 2]
A Phase 1/2 pilot trial evaluating the HSPPC-96 vaccine in combination with ipilimumab for advanced melanoma has been withdrawn.
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CLINICAL_TRIALS withdrawal · 2015-12-11Clinical Trial Update: Study of the Anti-PD-1 Antibody Nivolumab in Combination With Dabrafenib and/or Trametinib [Phase 1]
A Phase 1 study evaluating nivolumab in combination with dabrafenib and/or trametinib for metastatic melanoma has been withdrawn.
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CLINICAL_TRIALS withdrawal · 2015-11-13Clinical Trial Update: Peripheral Stem Cell Transplantation in Treating Patients With Melanoma or Small Cell Lung, Breast, Testicular, or Kidney Cancer That is Metastatic or That Cannot Be Treated With Surgery [Phase 1]
Phase 1 trial of peripheral stem cell transplantation for metastatic or unresectable cancers including breast cancer, renal cell carcinoma, …