Melanoma
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CLINICAL_TRIALS trial_result · 2025-07-10Clinical Trial Update: HDAC Inhibitor Vorinostat in Resistant BRAF V600 Mutated Advanced Melanoma [Phase 1, Phase 2]
Clinical trial update reporting completion of a phase 1/2 study of the HDAC inhibitor vorinostat in resistant BRAF V600-mutated advanced mel…
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CLINICAL_TRIALS trial_result · 2025-07-10Clinical Trial Update: Radiation Therapy, Plasma Exchange, and Immunotherapy (Pembrolizumab or Nivolumab) for the Treatment of Melanoma [EARLY_Phase 1]
An early-phase trial evaluated radiation therapy, plasma exchange, and immunotherapy with pembrolizumab or nivolumab for melanoma. The trial…
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CLINICAL_TRIALS trial_result · 2025-07-08Clinical Trial Update: A Clinical Study of the Pharmacokinetics and Safety of BCD-263 and Opdivo® as Monotherapy in Subjects With Advanced Melanoma of the Skin [Phase 1]
A Phase 1 clinical trial assessing the pharmacokinetics and safety of BCD-263 and nivolumab (Opdivo) as monotherapy in patients with advance…
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CLINICAL_TRIALS trial_result · 2025-07-04Clinical Trial Update: Clinical Study of CMP-001 in Combination With Pembrolizumab or as a Monotherapy [Phase 1]
Phase 1 clinical study of CMP-001 in combination with pembrolizumab or as monotherapy for melanoma has completed.
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CLINICAL_TRIALS trial_result · 2025-07-04Clinical Trial Update: A Study of Autogene Cevumeran (RO7198457) as a Single Agent and in Combination With Atezolizumab in Participants With Locally Advanced or Metastatic Tumors [Phase 1]
This Phase 1 trial assesses Autogene Cevumeran (RO7198457) as a single agent and in combination with atezolizumab across multiple locally ad…
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CLINICAL_TRIALS trial_result · 2025-07-03Clinical Trial Update: Adoptive Cell Transfer of Autologous Tumor Infiltrating Lymphocytes and High-Dose Interleukin 2 in Select Solid Tumors [Phase 1]
Phase 1 trial of autologous tumor infiltrating lymphocytes with high-dose interleukin-2 in select solid tumors was terminated, with results …
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CLINICAL_TRIALS trial_result · 2025-07-01Clinical Trial Update: A Study to Investigate LYL845 in Adults With Solid Tumors [Phase 1]
Lyell Immunopharma reports termination of the Phase 1 trial evaluating LYL845 in adults with solid tumors, including melanoma, non-small cel…
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CLINICAL_TRIALS trial_result · 2025-06-29Clinical Trial Update: Dendritic Cells (White Blood Cells) Vaccination for Advanced Melanoma [Phase 1]
Phase 1 trial of dendritic cell vaccine therapy for advanced melanoma has completed.
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CLINICAL_TRIALS trial_result · 2025-06-29Clinical Trial Update: Symptom Management for YA Cancer Survivors [NA]
A completed clinical trial (NCT04035447) examining symptom management for young adult cancer survivors with results posted in 2025.
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CLINICAL_TRIALS trial_result · 2025-06-22Clinical Trial Update: Education for Prevention of Melanoma in Hispanic Populations [Phase 2]
A Phase 2 trial focusing on education for melanoma prevention in Hispanic populations was terminated; the document does not report results.
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CLINICAL_TRIALS trial_result · 2025-06-19Clinical Trial Update: A Study of BMS-986253 in Combination With Nivolumab or Nivolumab Plus Ipilimumab in Advanced Cancers [Phase 1, Phase 2]
A Phase 1/2 study of BMS-986253 in combination with nivolumab or nivolumab plus ipilimumab in advanced cancers has completed and posted resu…
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CLINICAL_TRIALS trial_result · 2025-06-15Clinical Trial Update: A Phase 1/2 Study of BA3071 in Patients With Solid Tumors [Phase 1, Phase 2]
This clinical trial update describes a Phase 1/2 study of BA3071 in patients with solid tumors, including non-small cell lung cancer and mel…
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CLINICAL_TRIALS trial_result · 2025-06-13Clinical Trial Update: A Study of LGK974 in Patients With Malignancies Dependent on Wnt Ligands [Phase 1]
Phase 1 clinical trial update of LGK974, a Wnt pathway inhibitor, in malignancies dependent on Wnt ligands; the study included several cance…
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CLINICAL_TRIALS trial_result · 2025-06-12Clinical Trial Update: Dendritic Cell Therapy With Pembrolizumab for Metastatic or Unresectable Melanoma [Phase 1, Phase 2]
A Phase 1/2 clinical trial update reports results for dendritic cell therapy combined with pembrolizumab in metastatic or unresectable melan…
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CLINICAL_TRIALS trial_result · 2025-06-11Clinical Trial Update: Evaluation of a Personalised Survivorship Care Plan App for Patients With Melanoma [NA]
This clinical trial update describes the evaluation of a personalized survivorship care plan app for patients with melanoma. Recruitment is …
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CLINICAL_TRIALS trial_result · 2025-06-08Clinical Trial Update: Safety and Tolerability of Recombinant Humanized Anti-PD-1 Monoclonal Antibody Toripalimab for Patients With Advanced Solid Tumors [Phase 1]
Phase 1 study assessing safety and tolerability of toripalimab in patients with advanced solid tumors, including melanoma and urothelial can…
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CLINICAL_TRIALS trial_result · 2025-06-08Clinical Trial Update: Testing Treatment With Encorafenib and Binimetinib Before Surgery for Melanoma With Lymph Node Involvement [Phase 2]
A Phase 2 trial testing the combination of encorafenib and binimetinib before surgery for melanoma with lymph node involvement has been term…
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CLINICAL_TRIALS trial_result · 2025-06-06Clinical Trial Update: Comparing Whole Brain Radiotherapy Using a Technique That Avoids the Hippocampus to Stereotactic Radiosurgery in Patients With Cancer That Has Spread to the Brain and Come Back in Other Areas of the Brain After Earlier Stereotactic Radiosurgery [Phase 3]
Phase 3 trial comparing hippocampus-sparing whole-brain radiotherapy to stereotactic radiosurgery for patients with brain metastases from va…
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CLINICAL_TRIALS trial_result · 2025-06-04Clinical Trial Update: Phase IB Study to Evaluate the Safety of Selinexor (KPT-330) in Combination With Multiple Standard Chemotherapy or Immunotherapy Agents in Patients With Advanced Malignancies [Phase 1]
A Phase Ib safety study of Selinexor (KPT-330) in combination with standard chemotherapy or immunotherapy agents for patients with advanced …
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CLINICAL_TRIALS trial_result · 2025-05-29Clinical Trial Update: Study of NGM120 in Subjects With Advanced Solid Tumors, Pancreatic Cancer, and Prostate Cancer Using Combination Therapy [Phase 1, Phase 2]
This update reports results from a Phase 1/2 study of NGM120 in combination therapy for patients with advanced solid tumors, including pancr…
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CLINICAL_TRIALS trial_result · 2025-05-21Clinical Trial Update: A Study of Ceralasertib Monotherapy and Ceralasertib Plus Durvalumab in Patients With Melanoma and Resistance to PD-(L)1 Inhibition [Phase 2]
A Phase 2 study evaluating ceralasertib as a standalone therapy and in combination with durvalumab in melanoma patients resistant to PD-(L)1…
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CLINICAL_TRIALS trial_result · 2025-05-15Clinical Trial Update: Radiation Therapy and MK-3475 for Patients With Recurrent/Metastatic Head and Neck Cancer, Renal Cell Cancer, Melanoma, and Lung Cancer [Phase 1]
Phase 1 study evaluating the safety of combining radiation therapy with pembrolizumab (MK-3475) in patients with recurrent/metastatic head a…
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CLINICAL_TRIALS trial_result · 2025-05-13Clinical Trial Update: Encorafenib and Binimetinib Before Local Treatment in Patients With BRAF Mutant Melanoma Metastatic to the Brain [Phase 2]
Phase 2 study evaluating encorafenib and binimetinib before local treatment in patients with BRAF-mutant melanoma that has spread to the bra…
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CLINICAL_TRIALS trial_result · 2025-05-13Clinical Trial Update: A Trial to See if the Combination of Fianlimab With Cemiplimab Works Better Than Pembrolizumab for Preventing or Delaying Melanoma From Coming Back After it Has Been Removed With Surgery [Phase 3]
This is a Phase 3 clinical trial evaluating whether combining fianlimab with cemiplimab can prevent or delay melanoma recurrence after surgi…
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CLINICAL_TRIALS trial_result · 2025-05-09Clinical Trial Update: Evaluation of Groin Lymphadenectomy Extent For Metastatic Melanoma [Phase 3]
Phase 3 clinical trial evaluating the extent of groin lymphadenectomy for metastatic melanoma to groin lymph nodes has completed.