Melanoma

CLINICAL_TRIALS trial_result · 2022-02-03

Clinical Trial Update: Vemurafenib With Lymphodepletion Plus Adoptive Cell Transfer & High Dose IL-2 Metastatic Melanoma [Phase 2]

Phase 2 clinical trial evaluating vemurafenib in combination with lymphodepletion, adoptive cell transfer, and high-dose IL-2 for metastatic…

CLINICAL_TRIALS trial_result · 2022-01-20

Clinical Trial Update: Dabrafenib, Trametinib and Hydroxychloroquine in Patients With Advanced BRAF Mutant Melanoma [Phase 1, Phase 2]

Phase 1/2 trial investigating dabrafenib, trametinib, and hydroxychloroquine in advanced BRAF-mutant melanoma has completed.

CLINICAL_TRIALS trial_result · 2021-12-13

Clinical Trial Update: A Dose Escalation Study Of PF-06801591 In Melanoma, Head And Neck Cancer (SCCHN), Ovarian, Sarcoma, Non-Small Cell Lung Cancer, Urothelial Carcinoma or Other Solid Tumors [Phase 1]

A Phase 1 dose-escalation study of PF-06801591 in multiple solid tumors including melanoma, head and neck cancer, ovarian cancer, sarcoma, n…

CLINICAL_TRIALS trial_result · 2021-12-09

Clinical Trial Update: Intratumoral Injections of LL37 for Melanoma [Phase 1, Phase 2]

Phase 1/Phase 2 clinical trial evaluating intratumoral injections of LL37 for melanoma has completed with posted results.

CLINICAL_TRIALS trial_result · 2021-12-02

Clinical Trial Update: To Evaluate the Efficacy Beyond Progression of Vemurafenib+Cobimetinib Associated With Local Treatment Compared to Second-line Treatment in Patients With BRAFV600+ Metastatic Melanoma in Focal Progression With First-line+Vemurafenib+Cobimetinib. [Phase 2]

Phase 2 trial evaluating whether continuing vemurafenib+cobimetinib with local treatment improves efficacy beyond progression versus second-…

CLINICAL_TRIALS trial_result · 2021-12-01

Clinical Trial Update: PROCLAIM: CX-072-002: Study of PD-L1 Probody Therapeutic CX-072 in Combination With Other Anticancer Therapy in Adults With Solid Tumors [Phase 2]

Phase 2 study of the PD-L1 Probody therapeutic CX-072 in combination with other anticancer therapy in adults with solid tumors, including un…

CLINICAL_TRIALS trial_result · 2021-11-23

Clinical Trial Update: Targeted Melanoma Detection With Skin Self-Examination During COVID-19 Restricted Physician Access [NA]

Clinical trial update on targeted melanoma detection using skin self-examination during COVID-19 restrictions, with completed status and pos…

CLINICAL_TRIALS trial_result · 2021-11-22

Clinical Trial Update: A Phase I/II Open-Label Study of Ipilimumab and GM-CSF Administered to Unresectable Stage IIIC and Stage IV Melanoma Patients [Phase 1, Phase 2]

Phase I/II open-label study of ipilimumab with GM-CSF in unresectable metastatic melanoma shows completed status with posted results.

CLINICAL_TRIALS trial_result · 2021-11-16

Clinical Trial Update: A Vaccine (CDX-1401) With or Without a Biologic Drug (CDX-301) for the Treatment of Patients With Stage IIB-IV Melanoma [Phase 2]

Phase 2 trial evaluating CDX-1401 vaccine with or without CDX-301 for various-stage melanoma has completed enrollment with results posted.

CLINICAL_TRIALS trial_result · 2021-11-11

Clinical Trial Update: Safety and Efficacy of Chimeric Antigen Receptor T Lymphocytes for Patients With Intermediate and Advanced Tumors [Phase 1, Phase 2]

Clinical trial update on CAR-T therapy for intermediate and advanced tumors, including melanoma and non-small cell lung cancer, across Phase…

CLINICAL_TRIALS trial_result · 2021-11-04

Clinical Trial Update: Sitravatinib With or Without Tislelizumab in Patients With Unresectable or Metastatic Melanoma [Phase 2]

Phase 2 clinical trial update evaluating sitravatinib with or without tislelizumab in unresectable or metastatic melanoma.

CLINICAL_TRIALS trial_result · 2021-10-29

Clinical Trial Update: Adjuvant, Combined Interleukin 2 (Proleukin) and DTIC (Dacarbazine) in High-risk Melanoma Patients [Phase 2]

Phase 2 trial update evaluating adjuvant interleukin-2 (Proleukin) combined with dacarbazine (DTIC) in high-risk metastatic melanoma patient…

CLINICAL_TRIALS trial_result · 2021-10-28

Clinical Trial Update: Perioperative Encobini in BRAFV600 Mutant Stage III (B/C/D) or Oligometastatic Stage IV Melanoma [Phase 2]

Phase 2 clinical trial update for perioperative encobini in BRAFV600-mutant melanoma with stage III/oligometastatic stage IV disease; curren…

CLINICAL_TRIALS trial_result · 2021-10-26

Clinical Trial Update: Fibrin Melanoma Axillary Node Study in Patients With Melanoma [NA]

Completed clinical trial evaluating fibrin-focused intervention in melanoma; results posted.

CLINICAL_TRIALS trial_result · 2021-10-25

Clinical Trial Update: Ipilimumab Administered to Stage IIIC Stage IV Melanoma After Reg. T Cell Depletion With Denileukin Diftitox [Phase 2]

Phase 2 trial evaluating ipilimumab after regulatory T cell depletion with denileukin diftitox in stage IIIC/IV melanoma was terminated; res…

CLINICAL_TRIALS trial_result · 2021-10-22

Clinical Trial Update: Efficacy and Safety Study of Niraparib in Melanoma With Genetic Homologous Recombination (HR) Mutation [Phase 2]

Phase 2 trial evaluating niraparib for metastatic melanoma with homologous recombination mutations; efficacy and safety data not specified i…

CLINICAL_TRIALS trial_result · 2021-10-05

Clinical Trial Update: An Investigational Immuno-therapy Study to Evaluate Safety and Effectiveness in Patients With Melanoma That Has Spread to the Brain, Treated With Nivolumab in Combination With Ipilimumab, Followed by Nivolumab by Itself [Phase 2]

Phase 2 trial evaluating safety and effectiveness of nivolumab plus ipilimumab, followed by nivolumab alone, in melanoma with brain metastas…

CLINICAL_TRIALS trial_result · 2021-09-29

Clinical Trial Update: Phase I/II Study of PDR001 in Patients With Advanced Malignancies [Phase 1, Phase 2]

Phase I/II trial update for PDR001 in advanced malignancies completed with posted results.

CLINICAL_TRIALS trial_result · 2021-09-22

Clinical Trial Update: A Study Using Tumor-Reactive Autologous Tumor Infiltrating Lymphocytes (TIL) in Metastatic Melanomas [Phase 2]

Phase 2 trial of tumor-reactive autologous tumor-infiltrating lymphocytes (TIL) in metastatic melanoma has terminated with posted results.

CLINICAL_TRIALS trial_result · 2021-09-20

Clinical Trial Update: myDC/pDC in Stage III Melanoma Patients [Phase 1, Phase 2]

Phase 1/2 clinical trial update on myDC/pDC therapy in Stage III melanoma patients has completed.

CLINICAL_TRIALS trial_result · 2021-09-16

Clinical Trial Update: CMP-001 in Combo With Nivolumab in Stage IIIB/C/D Melanoma Patients With Clinically Apparent Lymph Node Disease [Phase 2]

Phase 2 trial evaluating CMP-001 in combination with nivolumab for Stage IIIB/C/D melanoma with clinically apparent lymph node disease has c…

CLINICAL_TRIALS trial_result · 2021-09-01

Clinical Trial Update: Efficacy Study of Pharmacokinetic(PK)/Pharmacodynamic(PD) Relationship of Monotherapy MORAb-004 in Metastatic Melanoma [Phase 2]

Phase 2 study assessing PK/PD relationship of MORAb-004 monotherapy in metastatic melanoma has completed with posted results.

CLINICAL_TRIALS trial_result · 2021-08-18

Clinical Trial Update: TITAN (Tumoural Injection of T-VEC and Isolated Limb Perfusion) [Phase 1, Phase 2]

A phase 1/2 trial update evaluating Tumoural Injection of T-VEC with isolated limb perfusion in melanoma and sarcoma has completed.

CLINICAL_TRIALS trial_result · 2021-08-17

Clinical Trial Update: Concurrent Dabrafenib + Trametinib With Sterotactic Radiation in BRAF Mutation-Positive Malignant Melanoma and Brain Metastases [Phase 2]

Phase 2 trial investigating concurrent dabrafenib and trametinib with stereotactic radiotherapy for BRAF mutation-positive melanoma with bra…

CLINICAL_TRIALS trial_result · 2021-08-16

Clinical Trial Update: A Phase Ib Trial to Evaluate the Safety and Efficacy of FMT and Nivolumab in Subjects With Metastatic or Inoperable Melanoma, MSI-H, dMMR or NSCLC [Phase 1, Phase 2]

Phase Ib/II trial evaluating fecal microbiota transplant in combination with nivolumab for metastatic or inoperable melanoma and NSCLC; stat…

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