Melanoma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2025-03-12Clinical Trial Update: BRAF-/MEK-Inhibition With Dabrafenib and Trametinib in Melanoma Patients
A completed clinical trial update studying BRAF and MEK inhibition with dabrafenib and trametinib in melanoma patients.
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CLINICAL_TRIALS trial_result · 2025-03-10Clinical Trial Update: Multicenter Phase 1b Trial Testing the Neoadjuvant Combination of Domatinostat, Nivolumab and Ipilimumab in IFN-gamma Signature-low and IFN-gamma Signature-high RECIST 1.1-measurable Stage III Cutaneous or Unknown Primary Melanoma [Phase 1, Phase 2]
A multicenter Phase 1b/2 neoadjuvant trial evaluating the combination of domatinostat, nivolumab, and ipilimumab in stage III cutaneous or u…
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CLINICAL_TRIALS trial_result · 2025-03-10Clinical Trial Update: Study Comparing TIL to Standard Ipilimumab in Patients With Metastatic Melanoma [Phase 3]
Phase III study comparing tumor-infiltrating lymphocytes (TIL) therapy to ipilimumab in metastatic melanoma has completed.
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CLINICAL_TRIALS trial_result · 2025-03-10Clinical Trial Update: A Study of Ladiratuzumab Vedotin in Advanced Solid Tumors [Phase 2]
Phase 2 trial of ladiratuzumab vedotin in multiple advanced solid tumors was terminated, with results posted in March 2025.
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CLINICAL_TRIALS trial_result · 2025-03-07Clinical Trial Update: Pixatimod (PG545) Plus Nivolumab in PD-1 Relapsed/Refractory Metastatic Melanoma and NSCLC and With Nivolumab and Low-dose Cyclophosphamide in MSS Metastatic Colorectal Carcinoma (mCRC) [Phase 2]
Phase 2 clinical trial update on pixatimod (PG545) plus nivolumab in PD-1 relapsed/refractory metastatic melanoma and non-small cell lung ca…
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CLINICAL_TRIALS trial_result · 2025-03-07Clinical Trial Update: NAUTILUS: OKI-179 Plus Binimetinib in Patients with Advanced Solid Tumors in the RAS Pathway (Phase 1b) and NRAS-mutated Melanoma (Phase 2) [Phase 1, Phase 2]
Phase 1b and Phase 2 NAUTILUS trial evaluating OKI-179 plus binimetinib in NRAS-mutated melanoma and other RAS-pathway–altered solid tumors …
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CLINICAL_TRIALS trial_result · 2025-03-07Clinical Trial Update: ATL001 in Patients With Metastatic or Recurrent Melanoma [Phase 1, Phase 2]
The ATL001 trial in metastatic or recurrent melanoma (Phase 1/2) has been terminated, and results have been posted.
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CLINICAL_TRIALS trial_result · 2025-03-06Clinical Trial Update: Comparative Effectiveness of Targeted Therapies in BRAF Positive Metastatic Melanoma in the US
ClinicalTrials.gov update reports completion and results posting of a comparative effectiveness study evaluating targeted therapies for BRAF…
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CLINICAL_TRIALS trial_result · 2025-03-06Clinical Trial Update: MGD019 DART® Protein in Unresectable/Metastatic Cancer [Phase 1]
MGD019, a DART protein from MacroGenics, is being studied in a Phase 1 trial for unresectable/metastatic cancers, including non-small cell l…
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CLINICAL_TRIALS trial_result · 2025-03-06Clinical Trial Update: PRospective REgistry of Advanced Stage CancER (PREFER) Patients to Assess Prevalence of Actionable Biomarkers and Driver Mutations to Address Disparities in Precision Medicine
A completed multicancer registry study (PREFER) assessing the prevalence of actionable biomarkers and driver mutations across advanced cance…
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CLINICAL_TRIALS trial_result · 2025-03-05Clinical Trial Update: Taste and Smell Dysfunction in Patients More Than Two Years After Start of Immune Checkpoint Inhibitor Therapy
The study update reports observations of taste and smell dysfunction occurring more than two years after initiation of immune checkpoint inh…
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CLINICAL_TRIALS trial_result · 2025-02-27Clinical Trial Update: A Study to Compare Nivolumab Administered Subcutaneously vs Intravenous in Melanoma Participants Following Complete Resection [Phase 3]
Phase 3 trial comparing subcutaneous versus intravenous nivolumab in melanoma after complete resection has completed and posted results.
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CLINICAL_TRIALS trial_result · 2025-02-27Clinical Trial Update: Circulating Tumour DNA guidEd Therapy for Stage IIB/C mElanoma After surgiCal resecTION [Phase 2, Phase 3]
A Phase 2/3 clinical trial evaluating circulating tumor DNA-guided therapy for stage IIB/C melanoma after surgical resection has been termin…
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CLINICAL_TRIALS trial_result · 2025-02-20Clinical Trial Update: Combination Therapy With Nivolumab and PD-L1/IDO Peptide Vaccine to Patients With Metastatic Melanoma [Phase 1, Phase 2]
A Phase 1/2 study evaluated the combination of nivolumab with a PD-L1/IDO peptide vaccine in patients with metastatic melanoma. The trial ha…
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CLINICAL_TRIALS trial_result · 2025-02-18Clinical Trial Update: Interventional Study of INCB 99280 With Ipilimumab in Participants With Select Solid Tumors [Phase 1]
Phase 1 interventional trial evaluating INCB 99280 in combination with ipilimumab in select solid tumors has been terminated. The study, spo…
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CLINICAL_TRIALS trial_result · 2025-02-17Clinical Trial Update: Nivolumab (Opdivo®) Plus ABI-009 (Nab-rapamycin) for Advanced Sarcoma and Certain Cancers [Phase 1, Phase 2]
Phase 1/2 trial update evaluating nivolumab plus ABI-009 (nab-rapamycin) in patients with advanced sarcoma and selected cancers, with result…
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CLINICAL_TRIALS trial_result · 2025-02-17Clinical Trial Update: BostonGene and Exigent Genomic INsight Study
Clinical trial update indicates that the BostonGene-Exigent Genomic INsight study is currently recruiting participants across indications in…
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CLINICAL_TRIALS trial_result · 2025-02-13Clinical Trial Update: Targeted Radionuclide Therapy for Metastatic Melanoma [131I] ICF01012 [EARLY_Phase 1]
A Phase 1 early trial of the targeted radiopharmaceutical therapy [131I] ICF01012 for metastatic melanoma has completed.
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CLINICAL_TRIALS trial_result · 2025-02-13Clinical Trial Update: A Study to Compare Quality of Life and Compliance in Patients Receiving High-dose Interferon Versus Pegylated Interferon in Patients With Surgically Resected Melanoma
A completed clinical trial comparing high-dose interferon with pegylated interferon in patients with surgically resected melanoma. The study…
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CLINICAL_TRIALS trial_result · 2025-02-11Clinical Trial Update: TIL-ACT After NMA Chemo with IL-2 and Nivo Rescue in Metastatic Melanoma (mMEL) [Phase 1]
Phase 1 clinical trial evaluating tumor-infiltrating lymphocyte adoptive cell therapy after non-myeloablative chemotherapy with IL-2 and niv…
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CLINICAL_TRIALS trial_result · 2025-02-10Clinical Trial Update: Relative Bioavailability Study of Subcutaneous Injection Versus Intravenous Infusion of Pembrolizumab (MK-3475) in Participants With Advanced Melanoma (MK-3475-555/KEYNOTE-555) [Phase 1]
Phase 1 study comparing subcutaneous vs intravenous pembrolizumab in adults with advanced melanoma evaluated relative bioavailability; resul…
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CLINICAL_TRIALS trial_result · 2025-02-06Clinical Trial Update: High Dose IL-2 in Combination With Anti-PD-1 to Overcome Anti-PD-1 Resistance in Metastatic Melanoma and Renal Cell Carcinoma [Phase 2]
Phase 2 trial evaluating high-dose interleukin-2 in combination with an anti-PD-1 therapy to overcome resistance in metastatic melanoma and …
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CLINICAL_TRIALS trial_result · 2025-02-05Clinical Trial Update: One-year Recurrence-free Survival of Melanoma Patients Eligible for a Sentinel Lymph Node Biopsy
A clinical trial update reporting the one-year recurrence-free survival among melanoma patients eligible for sentinel lymph node biopsy.
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CLINICAL_TRIALS trial_result · 2025-02-05Clinical Trial Update: A Study to Compare How Effective is Encorafenib Plus Binimetinib in Real-world and Clinical Trial Settings
A Pfizer-sponsored study compares the real-world effectiveness of encorafenib plus binimetinib against outcomes seen in clinical trials for …
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CLINICAL_TRIALS trial_result · 2025-02-03Clinical Trial Update: Effect of Bosentan in Patients With Metastatic Melanoma Treated With Dacarbazine (DTIC) [Phase 2]
Phase 2 clinical trial evaluating bosentan in patients with metastatic melanoma treated with dacarbazine (DTIC) has completed; Actelion spon…