Melanoma
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CLINICAL_TRIALS research · 2025-12-10Clinical Trial Update: Anti-PD 1 Brain Collaboration for Patients With Melanoma Brain Metastases [Phase 2]
Phase 2 clinical trial update on an anti-PD-1 therapy for melanoma with brain metastases; the study is currently active but not recruiting.
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CLINICAL_TRIALS research · 2025-12-08Clinical Trial Update: Oral Decitabine/Cedazuridine (DEC-C) in Combination With Nivolumab for Patients With Mucosal Melanoma [Phase 1, Phase 2]
Clinical trial update describes a Phase 1/2 study of oral decitabine/cedazuridine (DEC-C) in combination with nivolumab for patients with mu…
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CLINICAL_TRIALS research · 2025-12-04Clinical Trial Update: PET Imaging of Solid Tumors Using 124I-Humanized 3F8: A Pilot Study [NA]
A pilot PET imaging trial using the 124I-labeled humanized antibody 3F8 to visualize solid tumors, including melanoma, neuroblastoma, and sa…
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CLINICAL_TRIALS research · 2025-12-04Clinical Trial Update: A Trial of LBL-024 Monotherapy, LBL-024 Combined With LBL-007 or Toripalimab in Patients With Advanced Melanoma [Phase 1, Phase 2]
A Phase 1/2 trial is evaluating LBL-024 as monotherapy and in combination with LBL-007 or Toripalimab in patients with advanced melanoma. Th…
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CLINICAL_TRIALS research · 2025-12-04Clinical Trial Update: Axitinib + Ipilimumab in Advanced Melanoma [Phase 2]
Phase 2 clinical trial evaluating axitinib plus ipilimumab in advanced melanoma is currently recruiting.
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CLINICAL_TRIALS research · 2025-12-03Clinical Trial Update: An Efficacy Study of Adjuvant Treatment With the Personalized Cancer Vaccine mRNA-4157 and Pembrolizumab in Participants With High-Risk Melanoma (KEYNOTE-942) [Phase 2]
This Phase 2 trial evaluates adjuvant therapy with Moderna's personalized cancer vaccine mRNA-4157 in combination with pembrolizumab for hig…
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CLINICAL_TRIALS research · 2025-12-03Clinical Trial Update: A Study to Investigate the Safety and Efficacy of IOV-3001 in Adults With Advanced Melanoma Who Will Receive Lifileucel [Phase 1, Phase 2]
A Phase 1/2 clinical trial is evaluating the safety and efficacy of IOV-3001 in adults with advanced melanoma who will receive lifileucel; t…
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CLINICAL_TRIALS research · 2025-12-03Clinical Trial Update: Clear Me: Interception Trial to Detect and Clear Molecular Residual Disease in Patients With High-risk Melanoma [Phase 2]
A Phase 2 trial named Clear Me aims to detect and clear molecular residual disease in high-risk melanoma and is currently recruiting, includ…
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CLINICAL_TRIALS research · 2025-12-03Clinical Trial Update: Study of TBI-1301 (NY-ESO-1 Specific TCR Gene Transduced Autologous T Lymphocytes) in Patients With Solid Tumors [Phase 1]
Phase 1 study of TBI-1301, an NY-ESO-1–specific TCR gene-transduced autologous T cell therapy, in solid tumors; the trial is currently activ…
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CLINICAL_TRIALS research · 2025-12-03Clinical Trial Update: Study of GV20-0251 in Participants With Solid Tumor Malignancies [Phase 1, Phase 2]
GV20 Therapeutics is evaluating GV20-0251 in a Phase 1/2 trial for adults with various solid tumors, and the study is currently recruiting. …
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CLINICAL_TRIALS research · 2025-12-02Clinical Trial Update: Risk Stratification Among Individuals Who Have Many Moles on Their Skin
Clinical trial update on risk stratification among individuals with many moles (high-risk nevus phenotype). The goal is to better assess mel…
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CLINICAL_TRIALS research · 2025-11-26Clinical Trial Update: Opdualag vs. Cemiplimab/Fianlimab in Relation to the Immunological Response in Tumor and Peripheral Blood in Unresectable or Metastatic Melanoma
This clinical trial update outlines a head-to-head comparison of Opdualag versus Cemiplimab/Fianlimab in patients with unresectable or metas…
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CLINICAL_TRIALS research · 2025-11-24Clinical Trial Update: DETERMINE Trial Treatment Arm 03: Entrectinib in Adult, Paediatric and Teenage/Young Adult Patients With ROS1 Gene Fusion-Positive Cancers. [Phase 2, Phase 3]
This clinical trial update describes Arm 03 of the DETERMINE trial evaluating entrectinib in adults, pediatric, and teenage/young adult pati…
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CLINICAL_TRIALS research · 2025-11-24Clinical Trial Update: Neutrophil Biomarker Test for Predicting Clinical Benefit From Immunotherapy Based on Flow Cytometry Analysis
This clinical trial update describes a flow cytometry-based neutrophil biomarker test intended to predict clinical benefit from immunotherap…
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CLINICAL_TRIALS research · 2025-11-24Clinical Trial Update: A Study of GV20-0251 in Advanced or Refractory Solid Tumors [Phase 1]
This Phase 1 clinical trial update indicates that GV20-0251 is being studied in advanced or refractory solid tumors and is currently recruit…
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CLINICAL_TRIALS research · 2025-11-21Clinical Trial Update: A Study of HFB200301 as a Single Agent and in Combination With Tislelizumab in Adult Patients With Advanced Solid Tumors [Phase 1]
This is a Phase 1 clinical trial update for HiFiBiO's HFB200301 as a single agent and in combination with tislelizumab in adults with advanc…
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CLINICAL_TRIALS research · 2025-11-21Clinical Trial Update: A Study of HFB200603 as a Single Agent and in Combination With Tislelizumab in Adult Patients With Advanced Solid Tumors [Phase 1]
Phase 1 study of HFB200603 as a single agent and in combination with tislelizumab in adults with advanced solid tumors, including renal cell…
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CLINICAL_TRIALS research · 2025-11-21Clinical Trial Update: A Phase II Clinical Study of Multimodal Ablation Combined With Systemic Drug Therapy for Advanced Solid Tumors. [Phase 2]
Phase II clinical trial evaluating multimodal ablation with systemic drug therapy for advanced solid tumors, currently recruiting.
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CLINICAL_TRIALS research · 2025-11-21Clinical Trial Update: A Study to Evaluate Adze1.C in Participants With Metastatic Melanoma [Phase 1]
This clinical trial update describes a Phase 1 study of Adze1.C in participants with metastatic melanoma, which is currently recruiting.
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CLINICAL_TRIALS research · 2025-11-20Clinical Trial Update: FUSA With Intratumoral PolyICLC in Regionally Advanced Resectable Melanoma [EARLY_Phase 1]
A clinical trial update indicates a study of FUSA with intratumoral PolyICLC for regionally advanced resectable melanoma is in early Phase 1…
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CLINICAL_TRIALS research · 2025-11-20Clinical Trial Update: A Retrospective Observational Study on the Long-term Effects of Ipilimumab-treated Pediatric Participants in the Dutch Melanoma Treatment Registry (DMTR)
A retrospective observational study examining long-term safety and outcomes in pediatric melanoma patients treated with ipilimumab within th…
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CLINICAL_TRIALS research · 2025-11-19Clinical Trial Update: Circulating Tumor Cells and Melanoma: Comparing the EPISPOT and CellSearch Techniques
A completed clinical trial evaluating circulating tumor cell detection methods EPISPOT and CellSearch in patients with metastatic melanoma.
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CLINICAL_TRIALS research · 2025-11-19Clinical Trial Update: Mirdametinib in Patients With Advanced NF1-mutant Melanoma [Phase 2]
Phase 2 clinical trial evaluating Mirdametinib in patients with advanced or metastatic NF1-mutant melanoma is currently recruiting.
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CLINICAL_TRIALS research · 2025-11-18Clinical Trial Update: Use of Serial Plasma NGS as a New Efficacy Metric to Guide Immunotherapy Treatment Discontinuation [NA]
Massachusetts General Hospital describes using serial plasma NGS as a new efficacy metric to guide immunotherapy treatment discontinuation. …
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CLINICAL_TRIALS research · 2025-11-18Clinical Trial Update: Ovarian Reserve and Semen Parameters Evolution During Adjuvant Therapy in Melanoma
Investigates how adjuvant therapy for melanoma affects ovarian reserve and semen parameters. The study tracks reproductive hormones and seme…