Malignant Glioma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2022-06-23Clinical Trial Update: TTFields and Pulsed Bevacizumab for Recurrent Glioblastoma [Phase 2]
Phase 2 trial update on TTFields combined with pulsed bevacizumab for recurrent glioblastoma has been terminated.
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CLINICAL_TRIALS trial_result · 2022-06-09Clinical Trial Update: Ferumoxytol in Improving MR Imaging in Patients With High-Grade Brain Tumors or Cerebral Metastases [NA]
Trial update for Ferumoxytol assessing its utility in improving MR imaging for high-grade brain tumors and cerebral metastases; study comple…
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CLINICAL_TRIALS trial_result · 2022-06-08Clinical Trial Update: Stage 1: Marizomib + Bevacizumab in WHO Gr IV GBM; Stage 2: Marizomib Alone; Stage 3: Combination of Marizomib and Bevacizumab [Phase 1, Phase 2]
Phase 1/2 trial evaluating marizomib with bevacizumab, then marizomib alone, then marizomib with bevacizumab in malignant glioma/glioblastom…
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CLINICAL_TRIALS trial_result · 2022-05-03Clinical Trial Update: Combination Chemotherapy With or Without Sodium Thiosulfate in Preventing Low Platelet Count While Treating Patients With Malignant Brain Tumors [Phase 2]
Phase 2 clinical trial evaluating chemotherapy with or without sodium thiosulfate to prevent low platelet counts in malignant glioma patient…
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CLINICAL_TRIALS trial_result · 2022-04-18Clinical Trial Update: Tremelimumab and Durvalumab in Combination or Alone in Treating Patients With Recurrent Malignant Glioma [Phase 2]
Phase 2 trial evaluating tremelimumab and durvalumab, alone or in combination, for recurrent malignant glioma including recurrent glioblasto…
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CLINICAL_TRIALS trial_result · 2022-03-09Clinical Trial Update: Study of Cabiralizumab in Combination With Nivolumab in Patients With Selected Advanced Cancers [Phase 1]
Phase 1 trial assessing cabiralizumab with nivolumab in selected advanced cancers has completed with posted results.
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CLINICAL_TRIALS trial_result · 2021-12-09Clinical Trial Update: Impact of Surgery on the Treatment of Supratentorial Malignant Gliomas in Subjects Aged 70 and Over [Phase 3]
Phase 3 trial evaluating the impact of surgery on treatment outcomes for supratentorial malignant gliomas in subjects aged 70 and over. Comp…
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FDA approval · 2021-11-23FDA Approved: TEMOZOLOMIDE — Original Application (Nivagen Pharmaceuticals, Inc.)
FDA approved temozolomide from Nivagen Pharmaceuticals under an original application for the treatment of malignant gliomas, including gliob…
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CLINICAL_TRIALS trial_result · 2021-10-28Clinical Trial Update: Sorafenib, Valproic Acid, and Sildenafil in Treating Patients With Recurrent High-Grade Glioma [Phase 2]
A Phase 2 trial evaluating a combination of sorafenib, valproic acid, and sildenafil in patients with recurrent high-grade glioma has comple…
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CLINICAL_TRIALS trial_result · 2021-08-27Clinical Trial Update: Ribociclib and Everolimus in Treating Children With Recurrent or Refractory Malignant Brain Tumors [Phase 1]
Phase 1 trial evaluating ribociclib with everolimus in pediatric patients with recurrent or refractory malignant brain tumors; completed wit…
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CLINICAL_TRIALS trial_result · 2021-01-28Clinical Trial Update: Cytomegalovirus (CMV) RNA-Pulsed Dendritic Cells for Pediatric Patients and Young Adults With WHO Grade IV Glioma, Recurrent Malignant Glioma, or Recurrent Medulloblastoma [Phase 1]
Phase 1 trial evaluating CMV RNA-pulsed dendritic cells in pediatric and young adult patients with recurrent malignant glioma and related br…
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CLINICAL_TRIALS trial_result · 2020-12-02Clinical Trial Update: Bevacizumab Beyond Progression (BBP) [Phase 2]
Phase 2 clinical trial update on Bevacizumab Beyond Progression in malignant glioma including glioblastoma and gliosarcoma; results posted a…
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FDA approval · 2020-11-20FDA Approved: TEMODAR — Supplemental Application (Merck Sharp & Dohme LLC)
The FDA approved a supplemental application for Temodar (temozolomide) filed by Merck Sharp & Dohme LLC, resulting in updated labeling to re…
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CLINICAL_TRIALS trial_result · 2020-10-19Clinical Trial Update: Clinical and Molecular-Metabolic Phase II Trial of Perifosine for Recurrent/Progressive Malignant Gliomas [Phase 2]
Phase II trial of perifosine for recurrent/progressive malignant gliomas completed; results posted.
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CLINICAL_TRIALS trial_result · 2020-09-03Clinical Trial Update: Study Evaluating ABT-414 in Japanese Subjects With Malignant Glioma [Phase 1, Phase 2]
Clinical trial update for ABT-414 in Japanese subjects with malignant glioma (phase 1/2) completed.
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CLINICAL_TRIALS trial_result · 2020-07-24Clinical Trial Update: Phase 2 Study of Sym004 for Adult Patients With Recurrent Glioblastoma [Phase 2]
Phase 2 study of Sym004 in adults with recurrent glioblastoma has completed; results posted in 2020.
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CLINICAL_TRIALS trial_result · 2020-04-06Clinical Trial Update: SarCNU in Treating Patients With Recurrent Malignant Glioma [Phase 2]
Phase 2 clinical trial update for SarCNU in patients with recurrent malignant glioma.
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CLINICAL_TRIALS trial_result · 2020-04-03Clinical Trial Update: 18F-DOPA-PET in Finding Tumors in Patients With Newly Diagnosed Gliomas Undergoing Radiation Therapy [Phase 2]
A Phase 2 study evaluating 18F-DOPA-PET imaging to locate tumors in patients with newly diagnosed malignant glioma undergoing radiation ther…
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CLINICAL_TRIALS trial_result · 2020-03-26Clinical Trial Update: Nivolumab With DC Vaccines for Recurrent Brain Tumors [Phase 1]
Phase 1 trial evaluating nivolumab in combination with dendritic cell vaccines for recurrent brain tumors has completed with results posted.
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CLINICAL_TRIALS trial_result · 2020-01-27Clinical Trial Update: First in Patient Study for PF-06840003 in Malignant Gliomas [Phase 1]
Phase 1 trial update for PF-06840003 in malignant gliomas has been terminated; results posted.
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FDA approval · 2019-11-22FDA Approved: TEMODAR — Supplemental Application (Merck Sharp & Dohme LLC)
The FDA approved a supplemental application for TEMODAR (temozolomide) submitted by Merck Sharp & Dohme LLC.
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CLINICAL_TRIALS trial_result · 2019-08-21Clinical Trial Update: CAR T Cell Receptor Immunotherapy Targeting EGFRvIII for Patients With Malignant Gliomas Expressing EGFRvIII [Phase 1, Phase 2]
Phase 1/2 trial of EGFRvIII-targeted CAR T cell therapy for malignant gliomas expressing EGFRvIII has completed with results posted.
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CLINICAL_TRIALS trial_result · 2018-12-19Clinical Trial Update: Lacosamide in Preventing Seizures in Participants With Malignant Glioma [NA]
Clinical trial update for lacosamide in preventing seizures in participants with malignant glioma; study terminated with results posted in 2…
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FDA approval · 2018-12-05FDA Approved: GLIADEL — Supplemental Application (Azurity Pharmaceuticals, Inc.)
The FDA approved a supplemental application for GLIADEL (carmustine) submitted by Azurity Pharmaceuticals, Inc., resulting in changes to the…
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CLINICAL_TRIALS trial_result · 2018-09-28Clinical Trial Update: PVSRIPO for Recurrent Glioblastoma (GBM) [Phase 1]
Phase 1 clinical trial update for PVSRIPO in recurrent glioblastoma (GBM) completed with results posted in 2018.