Malignant Glioma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-03-04Clinical Trial Update: A Study of the Treatment of Recurrent Malignant Glioma With rQNestin34.5v.2 [Phase 1]
Phase 1 clinical trial update on rQNestin34.5v.2 for recurrent malignant glioma, including glioblastoma and related gliomas, with status cur…
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CLINICAL_TRIALS trial_result · 2026-03-04Clinical Trial Update: Comprehensive Analysis of Chemotherapy and Targeted Therapy Outcomes in Recurrent Malignant Gliomas
This clinical trial update reports a comprehensive analysis of chemotherapy and targeted therapy outcomes in recurrent malignant gliomas, in…
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CLINICAL_TRIALS research · 2026-03-03Clinical Trial Update: Pembrolizumab (MK-3475) in Patients With Recurrent Malignant Glioma With a Hypermutator Phenotype [NA]
Clinical trial update: pembrolizumab is being studied in patients with hypermutator phenotype recurrent malignant glioma; the trial is curre…
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CLINICAL_TRIALS research · 2026-03-03Clinical Trial Update: T2 Star Magnetic Resonance Imaging and Biomarker Blood Testing to Predict the Change and Progress of Malignant Gliomas [NA]
Clinical trial investigating T2* MRI imaging and blood biomarker testing to predict changes and progression in malignant glioma. The study i…
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CLINICAL_TRIALS research · 2026-03-02Clinical Trial Update: Mind-Body Intervention in Glioma Couples [NA]
Clinical trial update for a mind-body intervention targeting glioma patients and their partners. The study is currently active but not recru…
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CLINICAL_TRIALS withdrawal · 2026-02-10Clinical Trial Update: HSV G207 With a Single Radiation Dose in Children With Recurrent High-Grade Glioma [Phase 2]
A Phase 2 trial evaluating HSV G207 with a single radiation dose for children with recurrent high-grade glioma has been withdrawn from Clini…
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CLINICAL_TRIALS research · 2026-02-10Clinical Trial Update: Post-Operative Dosing of Dexamethasone in Patients With Brain Tumors After a Craniotomy, PODS Trial [Phase 2]
A Phase 2 trial (PODS) is evaluating post-operative dosing of dexamethasone in brain tumor patients after craniotomy; the study is currently…
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CLINICAL_TRIALS research · 2026-02-09Clinical Trial Update: Niraparib In Recurrent IDH 1/2 Gliomas [EARLY_Phase 1]
An early-phase 1 trial update evaluating niraparib in recurrent IDH1/2-mutant gliomas, including low-grade and malignant gliomas.
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CLINICAL_TRIALS research · 2026-02-05Clinical Trial Update: 5G-PEARL: Paxalisib in Malignant Brain Tumours [Phase 1, Phase 2]
This update describes a Phase 1/2 clinical trial (5G-PEARL) evaluating paxalisib in malignant brain tumors, currently recruiting.
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CLINICAL_TRIALS research · 2026-02-04Clinical Trial Update: CARv3-TEAM-E T Cells in Glioblastoma [Phase 1]
A Phase 1 clinical trial evaluating CARv3-TEAM-E T cells for glioblastoma and malignant glioma is currently recruiting.
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CLINICAL_TRIALS research · 2026-02-03Clinical Trial Update: Mapping of Electrical Properties in the Brain
A Mayo Clinic-led clinical trial is recruiting to map the electrical properties of the brain in patients with malignant glioma.
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CLINICAL_TRIALS research · 2026-01-23Clinical Trial Update: An Integrated Radio-immunological Approach
This clinical trial update indicates that the study 'An Integrated Radio-immunological Approach' (NCT05267509), sponsored by Istituto Oncolo…
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CLINICAL_TRIALS trial_result · 2026-01-22Clinical Trial Update: Re-Administration of C134 in Patients With Recurrent GBM (C134-HSV-1) [Phase 1]
Phase 1 study evaluating re-administration of C134 in patients with recurrent glioblastoma and related brain gliomas has been terminated.
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CLINICAL_TRIALS research · 2026-01-21Clinical Trial Update: 5G-RUBY: Avutometinib and Defactinib in Malignant Brain Tumours [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating the combination of Avutometinib and Defactinib in malignant brain tumors is currently recruiting.
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CLINICAL_TRIALS research · 2025-12-19Clinical Trial Update: Efficacy of a Mixed Distancial Neuropsychological Rehabilitation Program in Patients With Grade 2 or 3 Diffuse Glioma [NA]
A clinical trial is currently recruiting to assess the efficacy of a mixed distancial neuropsychological rehabilitation program in patients …
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CLINICAL_TRIALS research · 2025-12-04Clinical Trial Update: 18F-Fluciclovine PET-MRI in High-grade Glioma [EARLY_Phase 1]
An early-phase trial evaluating 18F-Fluciclovine PET-MRI for imaging high-grade glioma is currently recruiting.
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CLINICAL_TRIALS research · 2025-11-21Clinical Trial Update: A Phase I/IIa Study of C5252 in Patients With Intracranial Tumor [Phase 1, Phase 2]
ImmVira Pharma is planning a Phase I/IIa trial of C5252 for malignant glioma, with the study not yet recruiting.
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CLINICAL_TRIALS research · 2025-11-20Clinical Trial Update: Safety Study of the Repeated Opening of the Blood-brain Barrier With the SonoCloud® Device to Treat Malignant Brain Tumors in Pediatric Patients [Phase 1]
A Phase 1 safety study evaluating repeated opening of the blood-brain barrier using the SonoCloud device to treat pediatric malignant brain …
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CLINICAL_TRIALS research · 2025-11-14Clinical Trial Update: Simultaneous Multinuclear Metabolic MRI in Newly Diagnosed or Recurrent Glioma [EARLY_Phase 1]
An early Phase 1 clinical trial evaluating simultaneous multinuclear metabolic MRI in patients with glioma, including newly diagnosed and re…
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CLINICAL_TRIALS research · 2025-11-04Clinical Trial Update: Intratumoral Extracellular Metabolic Impact of DFMO and AMXT 1501 in Patients With Diffuse or High Grade Glioma [EARLY_Phase 1]
Early-phase trial evaluating the intratumoral metabolic impact of DFMO combined with AMXT-1501 in patients with diffuse or high-grade glioma…
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CLINICAL_TRIALS research · 2025-10-31Clinical Trial Update: ETAPA I: Peptide-based Tumor Associated Antigen Vaccine in GBM [Phase 1]
Phase 1 clinical trial evaluating a peptide-based tumor-associated antigen vaccine for glioblastoma, a malignant glioma. The study is curren…
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CLINICAL_TRIALS research · 2025-10-06Clinical Trial Update: Chimeric Antigen Receptor (CAR) T Cells With a Chlorotoxin Tumor-Targeting Domain for the Treatment of MMP2+ Recurrent or Progressive Glioblastoma [Phase 1]
Phase 1 study of chlorotoxin-targeted CAR T cells targeting MMP2 in patients with recurrent glioblastoma and other recurrent gliomas. The tr…
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CLINICAL_TRIALS trial_result · 2025-09-19Clinical Trial Update: Study of IK-595 in RAS- or RAF-altered Advanced Tumors [Phase 1]
Phase 1 study of IK-595 in Ras- or Raf-altered advanced tumors has been terminated.
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CLINICAL_TRIALS trial_result · 2025-09-09Clinical Trial Update: Safety and Tolerability of Carboxyamidotriazole Orotate (CTO) in Solid Tumors or With Temodar® in Glioblastoma or Other Recurrent Malignant Gliomas or in Combination With Temodar® and Radiation Therapy for Patients With Newly Diagnosed Glioblastoma and Malignant Gliomas [Phase 1]
A Phase 1 study reports on the safety and tolerability of Carboxyamidotriazole Orotate (CTO) in solid tumors and in combination with temozol…
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CLINICAL_TRIALS research · 2025-09-02Clinical Trial Update: Fitness and Nutrition in Glioma [NA]
This document reports a clinical trial update for a study on fitness and nutrition in malignant glioma. The trial is currently recruiting.