Malignant Glioma
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Study of Acetazolamide With Temozolomide in Adults With Newly Diagnosed or Recurrent Malignant Glioma [Phase 1]
A Phase 1 clinical trial is evaluating the combination of acetazolamide with temozolomide in adults with newly diagnosed or recurrent malign…
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Dual-Targeting CAR-NK Cells for Recurrent/Progressive Glioblastoma and High-Grade Glioma [Phase 1]
A Phase 1 clinical trial evaluating dual-targeting CAR-NK cells for recurrent/progressive glioblastoma and high-grade gliomas is currently r…
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CLINICAL_TRIALS trial_result · 2026-04-23Clinical Trial Update: Adoptive Cellular Therapy in Pediatric Patients With High-grade Gliomas [Phase 1]
Phase 1 trial evaluating adoptive cellular therapy in pediatric patients with high-grade gliomas; the study has been terminated and results …
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CLINICAL_TRIALS research · 2026-04-21Clinical Trial Update: Window of Opportunity Study of DSP-0390 in Gliomas [EARLY_Phase 1]
An early-phase 1 window-of-opportunity trial of DSP-0390 in malignant gliomas with IDH mutation is currently recruiting.
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: Non-invasive Glioma Characterization Through Molecular Imaging [NA]
This clinical trial update describes a study evaluating non-invasive molecular imaging to characterize gliomas and other brain tumors. It is…
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CLINICAL_TRIALS trial_result · 2026-04-17Clinical Trial Update: Association of Peripheral Blood Immunologic Response to Therapeutic Response to Adjuvant Treatment With Immune Checkpoint Inhibition (ICI) in Patients With Newly Diagnosed Glioblastoma or Gliosarcoma [Phase 2]
A Phase 2 clinical trial update exploring whether peripheral blood immunologic biomarkers predict response to adjuvant immune checkpoint inh…
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CLINICAL_TRIALS trial_result · 2026-04-16Clinical Trial Update: Assessment of Safety and Feasibility of ExAblate Blood-Brain Barrier (BBB) Disruption in GBM Patients
This clinical trial update summarizes the safety and feasibility findings of using ExAblate focused ultrasound to disrupt the blood-brain ba…
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CLINICAL_TRIALS trial_result · 2026-04-16Clinical Trial Update: A Phase I/II Study of Zotiraciclib for Recurrent Malignant Gliomas With Isocitrate Dehydrogenase 1 or 2 (IDH1 or IDH2) Mutations [Phase 1, Phase 2]
A Phase I/II clinical trial evaluating zotiraciclib for recurrent malignant gliomas with IDH1 or IDH2 mutations; the study is currently recr…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: Chronic CED of TPT for Recurrent Malignant Glioma [Phase 1]
Phase 1 trial evaluating chronic convection-enhanced delivery of TPT for recurrent malignant glioma is currently recruiting. The study lists…
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CLINICAL_TRIALS other · 2026-04-14Clinical Trial Update: Studying the Biology of IDH-mutant Gliomas Via Longitudinal Observation of 2-hydroxyglutarate (2-HG) Using MR Spectroscopy [Phase 2]
This ClinicalTrials.gov entry describes a Phase 2 study investigating the biology of IDH-mutant gliomas by longitudinally tracking 2-hydroxy…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Lutathera for Treatment of Recurrent or Progressive High-Grade CNS Tumors [Phase 1, Phase 2]
A Phase 1/2 clinical trial evaluating Lutathera (lutetium-177 dotatate) for recurrent or progressive high-grade central nervous system tumor…
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CLINICAL_TRIALS trial_result · 2026-04-13Clinical Trial Update: Retifanlimab With or Without Difluoromethylornithine for the Treatment of Progressive High Grade Gliomas [Phase 1, Phase 2]
Clinical trial update on a phase 1/2 study evaluating retifanlimab with or without difluoromethylornithine for progressive high-grade glioma…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Dabrafenib Combined With Trametinib After Radiation Therapy in Treating Patients With Newly-Diagnosed High-Grade Glioma [Phase 2]
A Phase 2 clinical trial update examining the combination of dabrafenib and trametinib after radiation therapy for newly diagnosed high-grad…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Pembrolizumab in Treating Younger Patients With Recurrent, Progressive, or Refractory High-Grade Gliomas, Diffuse Intrinsic Pontine Gliomas, Hypermutated Brain Tumors, Ependymoma or Medulloblastoma [Phase 1]
Phase 1 trial of pembrolizumab in pediatric patients with recurrent or refractory high-grade gliomas, including diffuse intrinsic pontine gl…
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CLINICAL_TRIALS research · 2026-04-06Clinical Trial Update: A Pilot Study Using 18F-DOPA PET-guided Radiotherapy in Gliomas
A Mayo Clinic-sponsored pilot trial evaluating 18F-DOPA PET-guided radiotherapy for malignant glioma.
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CLINICAL_TRIALS trial_result · 2026-04-06Clinical Trial Update: Optune for Children With High-Grade Glioma or Ependymoma, and Optune With Radiation Therapy for Children With DIPG [NA]
This ClinicalTrials.gov entry reports ongoing pediatric trials of Optune (Tumor Treating Fields) for malignant glioma and ependymoma, and in…
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CLINICAL_TRIALS trial_result · 2026-04-03Clinical Trial Update: 9-ING-41 in Patients With Advanced Cancers [Phase 2]
Actuate Therapeutics' Phase 2 trial of 9-ING-41 in patients with advanced cancers is currently active but not recruiting, with pancreatic ca…
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CLINICAL_TRIALS research · 2026-03-19Clinical Trial Update: IL13Rα2 CAR-T Cells Secreting Anti-PD-L1 Antibody for Recurrent Malignant Glioma [Phase 1]
This is a Phase 1 clinical trial evaluating IL13Rα2 CAR-T cells that secrete anti-PD-L1 antibody for recurrent malignant glioma; the study i…
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CLINICAL_TRIALS research · 2026-03-18Clinical Trial Update: Dual-Targeting CAR-NK Cells for Recurrent/Progressive Glioblastoma and High-Grade Glioma [Phase 1]
Phase 1 clinical trial evaluating dual-targeting CAR-NK cells for recurrent or progressive glioblastoma and high-grade glioma is currently r…
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CLINICAL_TRIALS research · 2026-03-13Clinical Trial Update: BGB-290 and Temozolomide in Treating Isocitrate Dehydrogenase (IDH)1/2-Mutant Grade I-IV Gliomas [Phase 1]
A Phase 1 clinical trial evaluating the combination of BGB-290 with temozolomide in patients with IDH1/IDH2-mutant gliomas, including gliobl…
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CLINICAL_TRIALS research · 2026-03-12Clinical Trial Update: Testing the Addition of an Anti-Cancer Drug, AZD1390, During Radiation Therapy for Newly Diagnosed High Grade Glioma, Diffuse Midline Glioma, or Diffuse Intrinsic Pontine Glioma [Phase 1]
A Phase 1 trial evaluating the addition of AZD1390 to radiation therapy for newly diagnosed pediatric high-grade gliomas, including diffuse …
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CLINICAL_TRIALS trial_result · 2026-03-06Clinical Trial Update: Photodynamic Diagnosis for Malignant Brain Glioma With 5-Aminolevulinic Acid（5-ALA） [Phase 3]
A Phase 3 trial evaluating photodynamic diagnosis with 5-aminolevulinic acid (5-ALA) for malignant glioma of the brain has completed.
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CLINICAL_TRIALS trial_result · 2026-03-06Clinical Trial Update: D2C7 for Adult Patients With Recurrent Malignant Glioma [Phase 1]
Phase 1 trial update of D2C7 in adults with recurrent malignant glioma has completed.
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CLINICAL_TRIALS research · 2026-03-05Clinical Trial Update: MSC-DNX-2401 in Treating Patients With Recurrent High-Grade Glioma [Phase 1]
Phase 1 trial evaluating mesenchymal stem cell-delivered DNX-2401 for recurrent high-grade glioma. The study is currently recruiting.
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CLINICAL_TRIALS research · 2026-03-05Clinical Trial Update: CUE-102 in Recurrent Glioblastoma [Phase 1]
Phase 1 clinical trial update for CUE-102 in recurrent glioblastoma showing the study is currently recruiting.