Malaria
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CLINICAL_TRIALS trial_result · 2025-04-25Clinical Trial Update: VAC069: A Study of Blood-stage Controlled Human P. Vivax Infection [EARLY_Phase 1]
This update reports completion of VAC069, a Phase 1 study evaluating blood-stage controlled human Plasmodium vivax infection, with results p…
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CLINICAL_TRIALS trial_result · 2025-04-20Clinical Trial Update: Chlorproguanil-Dapsone in Pregnant Women [Phase 1]
Phase 1 trial evaluating chlorproguanil-dapsone in pregnant women with malaria was terminated; no results were reported in the update.
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CLINICAL_TRIALS trial_result · 2025-04-16Clinical Trial Update: Pyronaridine in Healthy Adult Participants Infected With Blood Stage Malaria [Phase 1]
Phase 1 study evaluating safety, tolerability, and pharmacokinetics of Pyronaridine in healthy adult participants experimentally infected wi…
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CLINICAL_TRIALS trial_result · 2025-04-02Clinical Trial Update: L9LS MAb in Malian Adults [Phase 2]
Phase 2 trial results for the L9LS monoclonal antibody in Malian adults with malaria have been posted.
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FDA approval · 2025-03-31FDA Approved: DOXYCYCLINE — Supplemental Application (Par Health USA, LLC)
The FDA approved a supplemental application for doxycycline from Par Health USA, LLC under an ANDA, authorizing changes to the generic produ…
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CLINICAL_TRIALS research · 2025-03-30Clinical Trial Update: Evaluation of IR3535 as a Spatial Repellent for Malaria Control. [NA]
This clinical trial update concerns evaluating IR3535 as a spatial repellent for malaria control. The study is currently active but not recr…
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CLINICAL_TRIALS trial_result · 2025-03-28Clinical Trial Update: A Study of the Plasmodium Falciparum Malaria Vaccine Candidate Pfs48/45 in Matrix-M Adjuvant in the UK [EARLY_Phase 1]
Early-phase 1 study of the Pfs48/45 malaria vaccine candidate with Matrix-M adjuvant in the UK was terminated, with results posted.
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CLINICAL_TRIALS research · 2025-03-25Clinical Trial Update: Gestational Sulfadoxine-pyrimethamine and Azithromycin Treatment to Prevent Preterm Birth [Phase 3]
Phase 3 clinical trial evaluating gestational sulfadoxine-pyrimethamine and azithromycin to prevent preterm birth; the study is active but n…
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CLINICAL_TRIALS trial_result · 2025-03-19Clinical Trial Update: Village Malaria Worker Expansion
The study reports completion of the Village Malaria Worker expansion trial led by the University of Oxford, assessing strategies to address …
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CLINICAL_TRIALS research · 2025-03-18Clinical Trial Update: Experimental Malaria Infection of Healthy Malaria-Naive Adults by Mosquito Bite With the Genetically Modified Plasmodium Falciparum NF54/iGP3 GAP [Phase 1]
Phase 1 clinical trial update for experimental malaria infection in healthy malaria-naive adults using genetically modified Plasmodium falci…
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CLINICAL_TRIALS trial_result · 2025-03-14Clinical Trial Update: Broad One Health Endectocide-based Malaria Intervention in Africa (BOHEMIA) [Phase 3]
The BOHEMIA trial is a Phase 3 study of a broad one-health endectocide-based intervention for malaria, and the study status is completed. Th…
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CLINICAL_TRIALS withdrawal · 2025-03-14Clinical Trial Update: MaCRA Part B in Côte d'Ivoire [NA]
A PATH-sponsored MaCRA Part B trial in Côte d'Ivoire for malaria has been withdrawn.
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CLINICAL_TRIALS withdrawal · 2025-03-14Clinical Trial Update: MaCRA Part B in Nigeria [NA]
The MaCRA Part B malaria trial in Nigeria, sponsored by PATH, has been withdrawn.
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CLINICAL_TRIALS trial_result · 2025-03-12Clinical Trial Update: Parasite Clearance and Protection From Infection (PCPI) in Cameroon [Phase 3]
Phase 3 clinical trial in Cameroon evaluating Parasite Clearance and Protection From Infection (PCPI) for malaria has completed.
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CLINICAL_TRIALS trial_result · 2025-03-12Clinical Trial Update: Parasite Clearance and Protection From Infection (PCPI) in Zambia [Phase 3]
A Phase 3 trial in Zambia evaluating Parasite Clearance and Protection From Infection (PCPI) for malaria has completed, per the trial status…
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CLINICAL_TRIALS research · 2025-03-07Clinical Trial Update: A Study to Test Experimental Blood Stage Malaria Vaccine in Burkina Faso. [Phase 1, Phase 2]
A Phase 1/2 clinical trial in Burkina Faso is evaluating an experimental blood-stage malaria vaccine; recruitment is ongoing.
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CLINICAL_TRIALS withdrawal · 2025-03-07Clinical Trial Update: Spatial Repellents for Malaria Control [NA]
A clinical trial evaluating spatial repellents for malaria control (NCT06122142) sponsored by the University of Notre Dame has been withdraw…
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CLINICAL_TRIALS trial_result · 2025-03-06Clinical Trial Update: Piperaquine Granule Formulation Relative Bioavailability and Food Effect Study in Healthy Volunteers. [Phase 1]
A Phase 1 study in healthy volunteers evaluated the relative bioavailability of a piperaquine granule formulation and the effect of food, wi…
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CLINICAL_TRIALS trial_result · 2025-03-04Clinical Trial Update: Efficacy and Safety of Sulphadoxine-pyrimethamine and Amodiaquine in Ghanaian Pregnant Women [Phase 3]
Phase 3 clinical trial update evaluating the efficacy and safety of Sulphadoxine-pyrimethamine and Amodiaquine in Ghanaian pregnant women wi…
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CLINICAL_TRIALS research · 2025-02-28Clinical Trial Update: Strengthening the Evidence for Policy on the RTS,S/AS01 Malaria Vaccine
A clinical trial update indicating ongoing recruitment in Ghana for the RTS,S/AS01 malaria vaccine to strengthen policy evidence.
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CLINICAL_TRIALS trial_result · 2025-02-26Clinical Trial Update: Pharmacokinetics of Antimalarials in Breastfeeding Ugandan Mother-infant Pairs
This document provides an update on pharmacokinetic studies of antimalarial drugs in breastfeeding mother-infant pairs in Uganda. The study …
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CLINICAL_TRIALS trial_result · 2025-02-24Clinical Trial Update: Trial to Evaluate the Safety, Immunogenicity and Protective Efficacy of Three or Five Administrations of GAP3KO Sporozoites [Phase 1]
This update reports the completion of a Phase 1 trial evaluating the safety, immunogenicity, and protective efficacy of three or five admini…
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CLINICAL_TRIALS trial_result · 2025-02-20Clinical Trial Update: A Study to Determine if New Types of Malaria Vaccines Are Safe, Effective and Lead to Immunity in Kenyan Adults [Phase 2]
A Phase 2 malaria vaccine trial conducted in Kenyan adults has been terminated.
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CLINICAL_TRIALS trial_result · 2025-02-19Clinical Trial Update: Safety, Tolerability, Pharmacokinetics and Protective Efficacy of MAM01 in Healthy Adults [Phase 1]
Phase 1 trial evaluating safety, tolerability, pharmacokinetics, and protective efficacy of MAM01 in healthy adults has been completed.
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CLINICAL_TRIALS research · 2025-02-19Clinical Trial Update: Trajectories and Mechanisms of Recovery From Malaria: An Observational Study
An observational study conducted by Imperial College London examining how patients recover from malaria, including trajectories and underlyi…