Malaria
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CLINICAL_TRIALS trial_result · 2026-08-28Clinical Trial Results: A Clinical Trial to Evaluate the Safety, Efficacy and Immune Responses After Vaccination With an Investigational RNA-based Vaccine Against Malaria [Phase 1, Phase 2]
Phase 1/2 trial results for an investigational RNA-based malaria vaccine assessing safety, efficacy, and immune responses were completed wit…
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EMA approval · 2026-08-21EMA Authorised: Artesunate Amivas (artesunate) — Amivas Ireland Ltd
The EMA authorises Artesunate Amivas (artesunate) for malaria, with Amivas Ireland Ltd as the marketing authorization holder, classified as …
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CLINICAL_TRIALS trial_result · 2026-06-18Clinical Trial Results: Pharmacokinetic Study of IV Artesunate to Treat Children With Severe Malaria [Phase 4]
Phase 4 pharmacokinetic study evaluating intravenous artesunate in children with severe malaria completed, with results posted.
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CLINICAL_TRIALS trial_result · 2026-06-12Clinical Trial Results: Safety, Tolerability, Pharmacokinetics and Protective Efficacy of MAM01 in Healthy Adults [Phase 1]
Phase 1 trial assessing safety, tolerability, pharmacokinetics, and protective efficacy of MAM01 in healthy adults for malaria.
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CLINICAL_TRIALS trial_result · 2026-06-08Clinical Trial Update: Modifying Immunity in Children With DihydROartemisinin-Piperaquine (MIC-DroP) [Phase 3]
Phase 3 clinical trial update evaluating dihydroartemisinin-piperaquine for modifying immunity in children with malaria; study status is act…
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CLINICAL_TRIALS trial_result · 2026-04-24Clinical Trial Update: First-in-Human PfSPZ-LARC2 Vaccination/CHMI [Phase 1]
First-in-human Phase 1 trial update for the PfSPZ-LARC2 malaria vaccine (CHMI), sponsored by NIAID, currently not recruiting.
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Laboratory Evaluation of Pregnancy Malaria Vaccine Candidates/In-vitro Testing of Pregnancy Malaria Vaccine Candidates
Clinical trial update detailing laboratory evaluation and in-vitro testing of pregnancy malaria vaccine candidates, with recruitment current…
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CLINICAL_TRIALS trial_result · 2026-04-24Clinical Trial Update: Safety Evaluation of PfSPZ Vaccine in Pregnant Women in Mali (MalVIP1) [Phase 1]
Phase 1 safety evaluation of the PfSPZ Vaccine in pregnant women in Mali (MalVIP1) is currently suspended.
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CLINICAL_TRIALS research · 2026-04-24Clinical Trial Update: Screening of Healthy Volunteers for Investigational Antimalarial Drugs, Malaria Vaccines, and Controlled Human Malaria Challenge
This clinical trial update notes that healthy volunteers are being screened for investigational antimalarial drugs, malaria vaccines, and co…
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CLINICAL_TRIALS research · 2026-04-23Clinical Trial Update: Safety and PK of MMV371 LAI in Healthy Adults and Adolescents in Rwanda [Phase 1]
Phase 1 trial update on the safety and pharmacokinetics of MMV371 LAI in healthy adults and adolescents in Rwanda; the study is not yet recr…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: Induced Blood-Stage Malaria in Healthy Malaria-Naive Adults to Assess the Safety and Infectivity of Plasmodium Vivax Challenge Agent and Evaluate Transmission in Mosquito Feeding Assays [Phase 1]
Phase 1 clinical trial in healthy malaria-naive adults to assess the safety and infectivity of a Plasmodium vivax challenge agent and to eva…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: Collection of Human Biospecimens for Basic and Clinical Research Into Globin Variants
NIAID-sponsored clinical trial update indicates recruitment is ongoing to collect human biospecimens for basic and clinical research into gl…
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CLINICAL_TRIALS trial_result · 2026-04-16Clinical Trial Update: Age De-escalation Safety Trial of PfSPZ-LARC2 Vaccine in Burkina Faso [Phase 1]
A Phase 1 safety trial testing age de-escalation of the PfSPZ-LARC2 malaria vaccine in Burkina Faso has completed, sponsored by Sanaria Inc.
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CLINICAL_TRIALS trial_result · 2026-04-15Clinical Trial Update: A Clinical Trial to Evaluate the Safety, Efficacy and Immune Responses After Vaccination With an Investigational RNA-based Vaccine Against Malaria [Phase 1, Phase 2]
Completed Phase 1/2 clinical trial evaluating an investigational RNA-based malaria vaccine for safety, efficacy, and immune responses.
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: Comparison of Two Strategies for Administering the R21-Matrix M Vaccine in a Context of Seasonal Malaria Transmission in Chad [Phase 4]
Phase 4 clinical trial update evaluating two strategies for administering the R21-Matrix M malaria vaccine in Chad during seasonal transmiss…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Modifying Immunity in Children With DihydROartemisinin-Piperaquine (MIC-DroP) [Phase 3]
Phase 3 clinical trial update for the malaria treatment dihydroartemisinin-piperaquine in children (MIC-DroP); the study is active but not c…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: A Phase 1 Study to Assess an Escalating Dose, Multi-prime Vaccination Schedule of R21/Matrix-M™ [Phase 1]
Phase 1 study of escalating-dose, multi-prime R21/Matrix-M malaria vaccine is currently active but not recruiting.
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CLINICAL_TRIALS trial_result · 2026-04-09Clinical Trial Update: To Evaluate Efficacy, Safety, Tolerability and PK of Intravenous Cipargamin in Participants With Severe Plasmodium Falciparum Malaria [Phase 2]
Phase 2 trial evaluating intravenous cipargamin in severe malaria has completed and posted results, detailing efficacy, safety, tolerability…
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CLINICAL_TRIALS trial_result · 2026-04-09Clinical Trial Update: Xpert® Tropical Fever Test on GeneXpert® Edge X System
A clinical trial update indicates Cepheid is enrolling by invitation to evaluate the Xpert Tropical Fever Test on the GeneXpert Edge X Syste…
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CLINICAL_TRIALS withdrawal · 2026-04-09Clinical Trial Update: L9LS-R21 Interaction [Phase 2]
A Phase 2 clinical trial evaluating L9LS-R21 for malaria has been withdrawn.
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CLINICAL_TRIALS trial_result · 2026-04-08Clinical Trial Update: Assessment of Safety and Immunogenicity of a Single Vial Presentation of R21/Matrix-M and Co-Administration With EPI Vaccines [Phase 1]
Phase 1 study evaluating the safety and immunogenicity of a single-vial R21/Matrix-M malaria vaccine, co-administered with EPI vaccines; the…
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CLINICAL_TRIALS research · 2026-04-08Clinical Trial Update: Host and Parasite Factors That Influence Susceptibility to Malaria Infection and Disease During Pregnancy and Early Childhood in Ouelessebougou and Bamako, Mali
A clinical trial in Mali is investigating how host and parasite factors influence susceptibility to malaria infection and disease during pre…
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CLINICAL_TRIALS research · 2026-04-06Clinical Trial Update: A Clinical Study of Piperaquine, Pyronaridine, and Artesunate Administered in Combination in Healthy Adults [Phase 1]
Phase 1 clinical trial in healthy adults assessing the safety and pharmacology of a fixed-dose combination of piperaquine, pyronaridine, and…
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CLINICAL_TRIALS research · 2026-03-30Clinical Trial Update: Malaria Transmission in Humans and Mosquitoes at the Area of Sabou, Burkina Faso
The clinical trial NCT04650815 on malaria transmission in humans and mosquitoes in Sabou, Burkina Faso has completed. Sponsored by NIAID, th…
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EMA approval · 2026-03-24EMA Authorised: Artesunate Amivas (artesunate) — Amivas Ireland Ltd
The European Medicines Agency authorised Artesunate Amivas (artesunate) for malaria, with orphan designation and marketing authorization gra…