Malaria
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CLINICAL_TRIALS research · 2018-06-14Clinical Trial Update: Markers of T Cell Suppression: Associations With Malaria Infection and Antimalarial Treatment in Malian Children
A completed clinical trial update examining how malaria infection and antimalarial treatment relate to markers of T cell suppression in Mali…
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CLINICAL_TRIALS trial_result · 2018-06-13Clinical Trial Update: A Safety and Efficacy Study of ChAdOx1 LS2 and MVA LS2 [Phase 1, Phase 2]
A safety and efficacy Phase 1/2 trial of malaria vaccine candidates ChAdOx1 LS2 and MVA LS2 by the University of Oxford has completed.
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CLINICAL_TRIALS trial_result · 2018-06-13Clinical Trial Update: A Safety and Efficacy Study of R21 +/- ChAd63/MVA ME-TRAP [Phase 1, Phase 2]
Update on safety and efficacy results from a phase 1/2 study of the malaria vaccines R21 with ChAd63/MVA ME-TRAP; the trial has completed.
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CLINICAL_TRIALS trial_result · 2018-05-15Clinical Trial Update: Metabolism and Pharmacokinetics of Primaquine Enantiomers in Human Volunteers, Study 1 [Phase 1]
Phase 1 study investigating metabolism and pharmacokinetics of primaquine enantiomers in human volunteers related to malaria. The study is c…
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FDA approval · 2018-05-15FDA Approved: HYDROXYCHLOROQUINE SULFATE — Original Application (Amneal Pharmaceuticals NY LLC)
FDA approved a generic hydroxychloroquine sulfate product from Amneal Pharmaceuticals NY LLC under an original application.
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FDA approval · 2018-05-08FDA Approved: HYDROXYCHLOROQUINE SULFATE — Original Application (Sun Pharmaceutical Industries, Inc.)
FDA approved hydroxychloroquine sulfate as a generic drug under an Original Application (ANDA201691) for Sun Pharmaceutical Industries, Inc.
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CLINICAL_TRIALS trial_result · 2018-05-03Clinical Trial Update: Spatial Repellent Products for Control of Vector Borne Diseases - Malaria - Indonesia [NA]
A completed clinical trial evaluating spatial repellent products for malaria control in Indonesia.
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CLINICAL_TRIALS research · 2018-05-02Clinical Trial Update: Optimization of Seasonal Malaria Chemoprevention (SMC) Delivery [NA]
Clinical trial update about optimizing the delivery of Seasonal Malaria Chemoprevention, with no results or status details provided.
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FDA approval · 2018-05-01FDA Approved: HYDROXYCHLOROQUINE SULFATE — Original Application (Dr. Reddy's Laboratories Inc.)
FDA approved the original ANDA for hydroxychloroquine sulfate (generic) from Dr. Reddy's Laboratories Inc. This approval authorizes marketin…
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CLINICAL_TRIALS research · 2018-05-01Clinical Trial Update: Liberia Insecticide Treated Durable Wall Linings Study: Protocol for a Cluster Randomised Trial (DL) [NA]
Protocol for a cluster-randomized trial in Liberia evaluating insecticide-treated durable wall linings for malaria control and related anemi…
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CLINICAL_TRIALS research · 2018-04-27Clinical Trial Update: Evaluation of the Performance of a hsRDT Versus cRDT in Reactive Case Detection of Malaria Infections [NA]
This clinical trial compares the performance of a highly sensitive rapid diagnostic test (hsRDT) to a conventional rapid diagnostic test (cR…
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CLINICAL_TRIALS trial_result · 2018-04-05Clinical Trial Update: Plasmodium Falciparum Clearance Rates in Response to Artesunate in Eastern Cambodia
The update reports Plasmodium falciparum clearance rates following artesunate treatment in eastern Cambodia. The study is sponsored by NIAID…
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CLINICAL_TRIALS trial_result · 2018-04-05Clinical Trial Update: Impact of TMP-SMX Prophylaxis on Malaria Infection and Immunity in Children in Uganda
A completed clinical trial evaluated the impact of TMP-SMX prophylaxis on malaria infection and immunity in Ugandan children.
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CLINICAL_TRIALS trial_result · 2018-03-27Clinical Trial Update: "Prolonging the Therapeutic Life Span of Artemisinin-based Combination Therapies (ACT) in Bagamoyo District, Tanzania" [Phase 4]
A Phase 4 clinical trial conducted in Tanzania aims to prolong the therapeutic life span of artemisinin-based combination therapies for falc…
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CLINICAL_TRIALS trial_result · 2018-03-23Clinical Trial Update: Evaluation of the Protective Efficacy of a Vaccine Derived From the Synthetic CS Protein of Plasmodium Vivax [Phase 2]
Phase 2 trial evaluating the protective efficacy of a vaccine derived from the synthetic circumsporozoite protein of Plasmodium vivax has be…
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CLINICAL_TRIALS trial_result · 2018-03-23Clinical Trial Update: Immunization of Human Volunteers With P. Vivax Irradiated Sporozoites [Phase 1, Phase 2]
Phase 1/Phase 2 trial update of immunizing volunteers with Plasmodium vivax irradiated sporozoites for malaria.
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CLINICAL_TRIALS trial_result · 2018-03-23Clinical Trial Update: Controlled Human Malaria Infection Model for Evaluation of Transmission-Blocking Interventions - Study 1 [Phase 1, Phase 2]
This update reports the completion of Radboud University Medical Center's Study 1, a Phase 1/2 controlled human malaria infection model used…
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CLINICAL_TRIALS trial_result · 2018-03-22Clinical Trial Update: Feasibility of the Vapor Nanobubble Technology for Malaria Diagnostics (MalariaSense) [NA]
A completed feasibility study evaluated Vapor Nanobubble Technology (MalariaSense) for malaria diagnostics.
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CLINICAL_TRIALS trial_result · 2018-03-22Clinical Trial Update: Primaquine's Gametocytocidal Efficacy in Malaria Asymptomatic Carriers [Phase 3]
Phase 3 trial evaluating primaquine's gametocytocidal efficacy in asymptomatic malaria carriers has completed.
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CLINICAL_TRIALS trial_result · 2018-03-12Clinical Trial Update: Clinical Performance of the Histidine Rich Protein 2 (HRP2) Highly Sensitive Rapid Diagnostic Test (HS-RDT) for Malaria Diagnosis in Pregnant Women in Papua New Guinea
Clinical trial update evaluating the performance of the Histidine Rich Protein 2 Highly Sensitive Rapid Diagnostic Test for diagnosing malar…
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CLINICAL_TRIALS trial_result · 2018-03-07Clinical Trial Update: A Trial of Seasonal Malaria Chemoprevention Plus Azithromycin in African Children [Phase 3]
Phase 3 trial update shows completion of testing for Seasonal Malaria Chemoprevention plus azithromycin in African children. The study evalu…
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CLINICAL_TRIALS trial_result · 2018-02-23Clinical Trial Update: Have Malaria Infections in Kenya Become Less Responsive to Artemisinin Treatment? [Phase 4]
Phase 4 trial update evaluating whether malaria infections in Kenya have become less responsive to artemisinin-based therapy; the trial stat…
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CLINICAL_TRIALS trial_result · 2018-02-19Clinical Trial Update: Partially-blind (Observer-blind) Study of Safety and Immunogenicity of Two Malaria Vaccines in Ghanaian Children [Phase 2]
Phase 2 trial update assessing safety and immunogenicity of two malaria vaccines in Ghanaian children.
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CLINICAL_TRIALS trial_result · 2018-02-07Clinical Trial Update: Evaluating the Role of Chloroquine for Malaria Elimination [Phase 2, Phase 3]
A completed Phase 2/Phase 3 trial evaluating the role of chloroquine for malaria elimination.
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CLINICAL_TRIALS trial_result · 2018-02-07Clinical Trial Update: Plasmodium Vivax Efficacy Trial in Cruzeiro do Sul, Acre, Brazil [NA]
A completed clinical trial evaluating the efficacy of a treatment against malaria (Plasmodium vivax) conducted in Cruzeiro do Sul, Acre, Bra…