Major Depressive Disorder
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2026-04-15Clinical Trial Update: A Study of Aticaprant in Adult and Elderly Participants With Major Depressive Disorder (MDD) [Phase 3]
Phase 3 study of Aticaprant for major depressive disorder has been terminated, according to the trial record.
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: Treatment ResistAnt Depression Subcallosal CingulatE Network DBS (TRANSCEND) [NA]
A clinical trial update indicating that Abbott Medical Devices is recruiting for TRANSCEND, a deep brain stimulation study targeting treatme…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: Enhancing Veteran-Clinical Collaboration in VA PRRCs [NA]
A VA-sponsored initiative aims to enhance veteran-clinical collaboration within VA PRRCs; the study is currently not yet recruiting.
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: The Effects of Cognitive Behavioral Therapy on Insulin Resistance in People With HIV [NA]
This clinical trial update describes ongoing research into the effects of cognitive behavioral therapy on insulin resistance in adults with …
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CLINICAL_TRIALS trial_result · 2026-04-15Clinical Trial Update: Green VR for Depression [NA]
A completed clinical trial evaluating the Green VR intervention for depression of mild to moderate severity.
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: Multi-component Family Intervention to Lower Depression and Address Intimate Partner Violence in Nepal [NA]
A clinical trial in Nepal is recruiting to test a multi-component family intervention designed to lower depression and address intimate part…
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: Cognitive Enhancement in Recurrent Depression (The COG-D-R Study) [NA]
A clinical trial from Vanderbilt University Medical Center seeks cognitive enhancement in recurrent depression; the study is currently not y…
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CLINICAL_TRIALS trial_result · 2026-04-14Clinical Trial Update: VR-Moodboost; an Innovative Virtual Reality Treatment for Adolescents With Depression [NA]
A completed clinical trial evaluating VR-Moodboost, a virtual reality treatment for adolescents with major depressive disorder.
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: Validity and Reliability of the Turkish Version of the Cardiac Depression Scale
A completed clinical trial evaluating the validity and reliability of the Turkish version of the Cardiac Depression Scale for individuals wi…
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: Efficacy and Safety of a Theta Burst Stimulation Protocol of Repetitive Transcranial Magnetic Stimulation in Treatment-Resistant Depression [NA]
This clinical trial update describes a theta burst stimulation protocol using repetitive transcranial magnetic stimulation for treatment-res…
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: Effects of Exercise and Virtual Reality on Depression [NA]
A clinical trial is evaluating whether exercise combined with virtual reality can reduce depressive symptoms in participants. The study is c…
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: Assessing Social Learning and Course Delivery Timing in Internet-delivered Cognitive Behaviour Therapy for Public Safety Personnel [NA]
This clinical trial update describes a study evaluating social learning and course delivery timing in internet-delivered cognitive behaviora…
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CLINICAL_TRIALS research · 2026-04-14Clinical Trial Update: Early Brainwave Biomarkers for Personalized Neuromodulation in Treatment-resistant Depression [NA]
A clinical trial registry entry describing research on early brainwave biomarkers to guide personalized neuromodulation for treatment-resist…
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FDA approval · 2026-04-13FDA Approved: SPRAVATO — Supplemental Application (Janssen Pharmaceuticals Inc.)
FDA approved a supplemental application for SPRAVATO (esketamine hydrochloride) from Janssen Pharmaceuticals Inc.
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CLINICAL_TRIALS trial_result · 2026-04-13Clinical Trial Update: Reducing Suicide Risk in Adolescents and Young Adults Via a Psychobehavioral Intervention to Regularize Daily Rhythms [NA]
A completed clinical trial evaluated a psychobehavioral intervention aimed at regularizing daily rhythms to reduce suicide risk in adolescen…
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CLINICAL_TRIALS trial_result · 2026-04-13Clinical Trial Update: Closed-loop Optimized rTMS for Depression [Phase 1]
A Phase 1 trial evaluating a closed-loop optimized repetitive transcranial magnetic stimulation (rTMS) approach for major depressive disorde…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: A Phase 2 Study of Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder [Phase 2]
Phase 2 clinical trial evaluating Zelquistinel vs placebo for reducing symptoms of Major Depressive Disorder; currently recruiting.
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Dextromethorphan-Bupropion on Striatal Activity in Adults With Major Depressive Disorder [Phase 2]
Phase 2 clinical trial evaluating the dextromethorphan–bupropion combination for major depressive disorder, currently recruiting to assess s…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Phase 3 Study of Adjunctive Treatment With Seltorexant in Adult and Elderly Participants With Major Depressive Disorder and Insomnia Symptoms [Phase 3]
A Phase 3 study is underway to test adjunctive Seltorexant in adults with major depressive disorder and insomnia symptoms. The sponsor is Ja…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Digital CBT for Insomnia and Depression [NA]
A University of Rochester trial is evaluating digital cognitive-behavioral therapy for depression and insomnia. The study is currently recru…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: Emotional Cognition: Establishing Constructs and Neural-Behavioral Mechanisms in Older Adults With Depression
This clinical trial update from UT Southwestern reports an ongoing study on emotional cognition and neural-behavioral mechanisms in older ad…
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: IPT-based Group Intervention by Non-specialist for Improvement of Depressive Symptoms in Community Young Adults in Brazil [NA]
A Brazil-based clinical trial is evaluating an interpersonal psychotherapy (IPT) group intervention delivered by non-specialists to improve …
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CLINICAL_TRIALS research · 2026-04-13Clinical Trial Update: rTMS With and Without Text4Support for the Treatment of Resistant Depression. [NA]
A clinical trial update indicates recruiting for a study of repetitive transcranial magnetic stimulation (rTMS) with and without Text4Suppor…
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CLINICAL_TRIALS trial_result · 2026-04-13Clinical Trial Update: Electroconvulsive Therapy Versus Intravenous Ketamine in Treatment-Resistant Major Depressive Disorder [NA]
A completed clinical trial compared electroconvulsive therapy with intravenous ketamine for treatment-resistant major depressive disorder.
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CLINICAL_TRIALS trial_result · 2026-04-13Clinical Trial Update: Phenomenological Explorations of the Esketamine-Induced Transient Dissociative State [NA]
A completed clinical trial investigating the phenomenology of the transient dissociative state induced by esketamine in individuals with dep…