Major Depressive Disorder
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: ACP-211 Monotherapy for Major Depressive Disorder With Inadequate Antidepressant Response [Phase 2]
Phase 2 ACP-211 monotherapy for major depressive disorder is currently recruiting, including treatment-resistant cases. The sponsor is ACADI…
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: Group Retreat Psilocybin Therapy for the Treatment of Anxiety and Depression in Patients With Metastatic Solid Tumors or Incurable Hematologic Malignancies [Phase 2]
Phase 2 clinical trial evaluating psilocybin therapy for anxiety and depression in patients with metastatic solid tumors or incurable hemato…
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: Peer-Delivered Behavioral Activation in a CCBHC [NA]
Wayne State University is recruiting for a clinical trial evaluating peer-delivered behavioral activation in a certified community behaviora…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression [Phase 2]
Phase 2 clinical trial update investigating the antidepressant effects of 2R,6R-hydroxynorketamine (HNK) as a glutamate-release enhancer for…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Neurobiological Mechanisms of Pathological Rumination and Effects of Aripiprazole [NA]
This clinical trial update investigates the neurobiological mechanisms of pathological rumination in major depressive disorder and assesses …
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Investigating Functional Changes in the Frontotemporal Cortex of Patients With Major Depressive Disorder Following Electroconvulsive Therapy or Magnetic Seizure Therapy Using Functional Near-infrared Spectroscopy (fNIRS) [NA]
A clinical trial evaluating how electroconvulsive therapy or magnetic seizure therapy affects frontotemporal brain function in major depress…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Be Well at Work-Plus: A Depression and Physical Activity Intervention for Hospital Service Workers (Aim 2) [NA]
Be Well at Work-Plus is a clinical trial evaluating a depression and physical activity intervention for hospital service workers. The study …
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Internet-Based Cognitive Behavioural Therapy (iCBT) for Anxiety and Depression in Singapore [NA]
Registry update for a National University of Singapore study evaluating internet-based cognitive behavioral therapy for mild-to-moderate dep…
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CLINICAL_TRIALS trial_result · 2026-04-16Clinical Trial Update: Using Technology to Optimize Collaborative Care Management of Depression in Urban and Rural Cancer Centers, SCOPE [NA]
This terminated University of Washington clinical trial tested technology-driven collaborative care for depression among cancer patients in …
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Smoking Cessation for Depressed Smokers [Phase 1, Phase 2]
An ongoing Phase 1/2 trial at MD Anderson Cancer Center is exploring smoking cessation in individuals with depression. The study is currentl…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Bright Light Therapy for Depressed Geriatric Inpatients [Phase 2]
A Phase 2 clinical trial evaluating bright light therapy for unipolar depression in geriatric inpatients is currently enrolling by invitatio…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: TRIPS - Treatment to Improve Depression and/or Anxiety Using Psilocybin-assisted Psychotherapy in Cancer Survivors [Phase 2]
Phase 2 trial evaluating psilocybin-assisted psychotherapy for depression and anxiety in cancer survivors, currently recruiting.
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Psilocybin-Assisted Psychotherapy in Patients With Advanced Cancer on Maintenance Therapy [Phase 2]
A Phase 2 trial evaluating psilocybin-assisted psychotherapy for depression and anxiety in patients with advanced cancer on maintenance ther…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Sleep Health in U.S. Marines [Phase 2]
Phase 2 clinical trial evaluating sleep health among U.S. Marines, with attention to depression and suicidality.
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Be Well at Work-Plus: A Depression and Physical Activity Intervention for Hospital Service Workers (Aim 3) [NA]
A status update on the Be Well at Work-Plus program’s Aim 3, evaluating a depression-focused intervention that includes physical activity fo…
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CLINICAL_TRIALS research · 2026-04-16Clinical Trial Update: Sleep and Circadian Interventions for College Students at High Risk of Suicide [NA]
A University of Pittsburgh trial is testing sleep and circadian interventions for college students at high risk of suicide; the study is cur…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: "A Study of a Deuterated Psilocin Analog (CYB003) in Humans With Major Depressive Disorder" [Phase 3]
This entry describes a Phase 3 clinical trial evaluating CYB003, a deuterated psilocin analog, for Major Depressive Disorder, which is curre…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: Feasibility and Safety of Ketamine for Suicidal Patients in the Emergency Department [Phase 1]
Phase 1 study assessing the feasibility and safety of ketamine for patients with suicidality presenting to the emergency department.
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: Development of a College Student-Delivered Cognitive-Behavioral Therapy (CBT) Intervention for Rural High School Students [NA]
A study assessing a college student-delivered CBT intervention for rural high school students addressing depression, anxiety, and stress, wi…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: Effects of a Salutogenic Strength-based Social Robot-assisted Intervention on the Depressive Symptoms and Sense of Coherence of Family Caregivers of Persons With Dementia [NA]
A registered clinical trial evaluating whether a salutogenic strength-based social robot-assisted intervention reduces depressive symptoms a…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: Use of a Smartphone Mobile Application (App) to Enhance Smoking Cessation Treatment [NA]
A clinical trial update on using a smartphone app to enhance smoking cessation treatment, sponsored by MD Anderson, with conditions includin…
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: CRISOL Mente: A Multilevel Community Intervention to Reduce Mental Health Disparities Among Latinos [NA]
Update on the CRISOL Mente trial, a multilevel community intervention to reduce mental health disparities among Latinos. The study is curren…
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CLINICAL_TRIALS trial_result · 2026-04-15Clinical Trial Update: Trial of Transcranial Photobiomodulation for Depression With PET and EEG Outcomes [NA]
A completed clinical trial evaluating transcranial photobiomodulation for depression, with PET and EEG outcomes.
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CLINICAL_TRIALS research · 2026-04-15Clinical Trial Update: NBI-1065845-MDD3026: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD) [Phase 3]
ClinicalTrials.gov update for the Phase 3 study NBI-1065845-MDD3026 evaluating NBI-1065845 as an adjunctive treatment in major depressive di…
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CLINICAL_TRIALS trial_result · 2026-04-15Clinical Trial Update: Postoperative Anxiety and Depression Among Chinese Elderly Patients
A completed clinical trial conducted at Chinese PLA General Hospital investigated postoperative anxiety and depression in elderly Chinese pa…