Major Depressive Disorder
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2025-05-30Clinical Trial Update: Trial of Centanafadine Efficacy and Safety as Monotherapy or as Adjunct to SSRI in Adults With Major Depressive Disorder [Phase 2]
A Phase 2 clinical trial evaluating centanafadine as monotherapy or as an SSRI adjunct in adults with major depressive disorder has complete…
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CLINICAL_TRIALS research · 2025-05-30Clinical Trial Update: Acceptability and Feasibility of an In-person 8-week Mindfulness-Based Cognitive Therapy Program Among Undergraduates [NA]
A ClinicalTrials.gov entry describes an 8-week in-person Mindfulness-Based Cognitive Therapy program for undergraduates, assessing acceptabi…
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CLINICAL_TRIALS research · 2025-05-30Clinical Trial Update: Improving Mental Health in Forcibly Displaced Populations [NA]
A Boston Medical Center-sponsored clinical trial is recruiting to improve mental health in forcibly displaced populations, focusing on anxie…
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CLINICAL_TRIALS research · 2025-05-30Clinical Trial Update: Storytelling and Mindfulness for Graduate Student Wellbeing [NA]
University of Wisconsin–Madison is conducting a clinical trial to test storytelling and mindfulness as a way to improve graduate student wel…
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CLINICAL_TRIALS trial_result · 2025-05-29Clinical Trial Update: Study in Major Depressive Disorder With NMRA-335140 (BTRX-335140) vs Placebo [Phase 2]
Phase 2 trial in major depressive disorder comparing NMRA-335140 (BTRX-335140) to placebo has completed and results have been posted.
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CLINICAL_TRIALS trial_result · 2025-05-29Clinical Trial Update: Closed-Loop Transcranial Alternating Current Stimulation for the Treatment of Depression [NA]
Completed clinical trial evaluating closed-loop transcranial alternating current stimulation for depression with results posted in 2025.
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CLINICAL_TRIALS research · 2025-05-29Clinical Trial Update: Ketogenic Intervention in Depression [NA]
A completed clinical trial investigating a ketogenic intervention for depression. No results details are provided in the update.
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CLINICAL_TRIALS research · 2025-05-29Clinical Trial Update: Individualized Functional Connectivity Targeting in aiTBS for Depression [Phase 2]
Phase 2 clinical trial update evaluating individualized functional connectivity targeting with accelerated intermittent theta-burst stimulat…
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CLINICAL_TRIALS trial_result · 2025-05-28Clinical Trial Update: Therapist-Guided Smartphone-Delivered CBT for MDD [NA]
A completed clinical trial evaluated therapist-guided cognitive behavioral therapy delivered via a smartphone for Major Depressive Disorder.…
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CLINICAL_TRIALS research · 2025-05-28Clinical Trial Update: Inflammatory and Glutamatergic Mechanisms of Sustained Threat in Adolescents With Depression
A UCLA-sponsored clinical trial is investigating inflammatory and glutamatergic mechanisms of sustained threat in adolescents with depressio…
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CLINICAL_TRIALS research · 2025-05-28Clinical Trial Update: RCT of At-Home tDCS for Depression in Pregnancy [NA]
A randomized controlled trial is evaluating at-home transcranial direct current stimulation for major depressive disorder during pregnancy. …
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CLINICAL_TRIALS trial_result · 2025-05-28Clinical Trial Update: Caregiver Depression in a Low-Resource Setting: Socio-Demographic Predictors of Major Depressive Disorder Among Family Caregivers of Breast Cancer Patients in Pakistan
A completed clinical trial from Rahmah Health Foundation investigating socio-demographic predictors of major depressive disorder among famil…
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CLINICAL_TRIALS trial_result · 2025-05-28Clinical Trial Update: PDA for Antidepressant Use in Pregnancy [NA]
A clinical trial evaluating a patient decision aid for antidepressant use during pregnancy has completed.
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CLINICAL_TRIALS trial_result · 2025-05-28Clinical Trial Update: Personalized Prevention of Depression in Primary Care [NA]
This clinical trial update notes that the study on personalized prevention of depression in primary care has completed.
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CLINICAL_TRIALS withdrawal · 2025-05-26Clinical Trial Update: Waitlist-Control Trial of Smartphone CBT for Major Depressive Disorder (MDD) [NA]
A waitlist-controlled trial of smartphone-delivered cognitive behavioral therapy for Major Depressive Disorder has been withdrawn.
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CLINICAL_TRIALS trial_result · 2025-05-25Clinical Trial Update: Online MBCT vs HEP for Depressive Symptoms in Older Adults: RCT [NA]
A completed randomized controlled trial comparing online Mindfulness-Based Cognitive Therapy to a health education program for depressive sy…
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CLINICAL_TRIALS research · 2025-05-25Clinical Trial Update: Telehealth Intervention Program for Older Adults [NA]
This clinical trial update indicates that the telehealth intervention program for older adults has completed. The study focused on depressio…
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CLINICAL_TRIALS research · 2025-05-25Clinical Trial Update: Sequential Bilateral Accelerated Theta Burst Stimulation in Adolescents With Suicidal Ideation [NA]
An ongoing clinical study evaluating sequential bilateral accelerated theta burst stimulation in adolescents with suicidal ideation and majo…
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CLINICAL_TRIALS research · 2025-05-25Clinical Trial Update: Implementation of a Multiple Intervention to Promote Healthy Lifestyles in Patients With Depression [NA]
A clinical trial update describing the implementation of multiple interventions aimed at promoting healthy lifestyles in patients with major…
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CLINICAL_TRIALS research · 2025-05-25Clinical Trial Update: Alternative Treatments To Prevent Cognitive Decline in Older Adults With Depression and Anxiety [NA]
This clinical trial update indicates that the study on alternative treatments to prevent cognitive decline in older adults with depression a…
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CLINICAL_TRIALS research · 2025-05-25Clinical Trial Update: Inflammation and Depression in People With HIV [Phase 2]
Phase 2 clinical trial evaluating the role of inflammation in depression among people with HIV; currently recruiting.
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FDA approval · 2025-05-23FDA Approved: BUPROPION HYDROCHLORIDE XL — Supplemental Application (Slate Run Pharmaceuticals, LLC)
The FDA approved a supplemental application for Bupropion hydrochloride XL from Slate Run Pharmaceuticals, approving the extended-release fo…
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CLINICAL_TRIALS research · 2025-05-23Clinical Trial Update: Investigation to Understand and Optimize Psilocybin [Phase 2]
A Phase 2 clinical trial investigating psilocybin for depression is currently recruiting. The study aims to better understand and optimize i…
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CLINICAL_TRIALS trial_result · 2025-05-23Clinical Trial Update: Combining rTMS and tDCS in Depression: an Exploratory Clinical Trial [NA]
An exploratory trial evaluating combined rTMS and tDCS for major depressive disorder, including treatment-resistant depression, has been ter…
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CLINICAL_TRIALS trial_result · 2025-05-22Clinical Trial Update: Engaging Mothers & Babies; Reimagining Antenatal Care for Everyone (EMBRACE) Study [NA]
The EMBRACE study evaluating reimagined antenatal care for mothers and babies has completed, with outcomes involving premature birth and mat…