Major Depressive Disorder
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2025-06-05Clinical Trial Update: Early Speaking Valve in Ventilator Weaning: Effects on Communication, Depression, and Quality of Life [NA]
A clinical trial update notes a study on using an early speaking valve to assist ventilator weaning, focusing on communication, depression, …
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CLINICAL_TRIALS withdrawal · 2025-06-05Clinical Trial Update: A Non-Interventional Pilot Study to Explore the Role of Gut Flora in Depression
A non-interventional pilot study investigating the role of gut microbiota in depression has been withdrawn from the clinical trial registry.
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CLINICAL_TRIALS research · 2025-06-05Clinical Trial Update: Effects of Transcranial Direct Current Stimulation (tDCS) in the Management of Suicidal Ideation [NA]
A clinical trial (NCT06009523) is evaluating the effects of transcranial direct current stimulation for managing suicidal ideation in indivi…
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CLINICAL_TRIALS withdrawal · 2025-06-05Clinical Trial Update: ANGIOTENSIN AGENTS AND REDUCTION OF THE PRESCRIPTION OF ANTIDEPRESSANT DRUGS: A RETROSPECTIVE COHORT STUDY USING REAL-WORLD DATA
A retrospective real-world study examined whether angiotensin agents (ACE inhibitors and ARBs) influence antidepressant prescribing. The tri…
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CLINICAL_TRIALS trial_result · 2025-06-04Clinical Trial Update: A Study of Seltorexant as Adjunctive Therapy to Antidepressants in Adult and Elderly Participants With Major Depressive Disorder With Insomnia Symptoms Who Have Responded Inadequately to Antidepressant Therapy [Phase 3]
Phase 3 study evaluating seltorexant as an adjunctive therapy to antidepressants in adults and elderly patients with major depressive disord…
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CLINICAL_TRIALS trial_result · 2025-06-04Clinical Trial Update: Psychotherapy Feasibility Pilot of the Carolina Recovery From Depression Protocol [NA]
A completed clinical trial evaluating the feasibility of the Carolina Recovery From Depression Protocol, a psychotherapy program for unipola…
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CLINICAL_TRIALS trial_result · 2025-06-04Clinical Trial Update: A Feasibility Study to Determine Whether the Botanical Garden Become a Region of Forest Therapy for Cancer Survivors [NA]
This completed feasibility study evaluated whether converting a botanical garden into a forest therapy region could benefit cancer survivors…
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CLINICAL_TRIALS research · 2025-06-04Clinical Trial Update: Cognitive and Affective Processes Online
A University of Minnesota–sponsored online study examining cognitive and affective processes in individuals with major depressive disorder i…
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CLINICAL_TRIALS withdrawal · 2025-06-04Clinical Trial Update: Waitlist-Control Trial of Smartphone CBT for Major Depressive Disorder (MDD), Withdrawn [NA]
A waitlist-controlled trial evaluating smartphone-based cognitive behavioral therapy for Major Depressive Disorder was withdrawn.
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CLINICAL_TRIALS trial_result · 2025-06-03Clinical Trial Update: A Tripartite Biopsychosocial Intervention Program Enhances Mental Health and Quality of Life in Elderly Patients With Depression Secondary to Geriatric Diseases [NA]
A completed clinical trial evaluating a tripartite biopsychosocial intervention shows improvements in mental health and quality of life amon…
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CLINICAL_TRIALS research · 2025-06-03Clinical Trial Update: Facilitated Transitions From Postpartum to Primary Care Coordination for People With Chronic Conditions [NA]
Massachusetts General Hospital is testing facilitated transitions from postpartum care to primary care coordination for people with chronic …
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CLINICAL_TRIALS research · 2025-06-03Clinical Trial Update: Local Participatory Systems Dynamics to Increase Reach of Evidence Based Addiction and Mental Health Care [NA]
A clinical trial using local participatory systems dynamics to broaden reach of evidence-based addiction and mental health care and is enrol…
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CLINICAL_TRIALS research · 2025-06-03Clinical Trial Update: Metabolic Profiling of Esketamine Treatment in Depressive Disorder
A clinical trial protocol evaluates metabolic profiling during Esketamine treatment for Major Depressive Disorder and is currently recruitin…
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CLINICAL_TRIALS trial_result · 2025-06-03Clinical Trial Update: Social Reward and Its Effect on Brain Functions in Psychotherapies for Mid- and Late-Life Depression [NA]
Completed clinical trial assessing how social reward affects brain function during psychotherapies for mid- and late-life major depressive d…
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CLINICAL_TRIALS research · 2025-06-03Clinical Trial Update: Ketamine for Postherpetic Neuralgia With Depression [Phase 4]
Phase 4 clinical trial evaluating ketamine for individuals with depression and postherpetic neuralgia; the study is currently not recruiting…
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CLINICAL_TRIALS trial_result · 2025-05-31Clinical Trial Update: Change in Social Media Use and Well-being Among College Students Receiving a One-week Exercise or Mindfulness Intervention [NA]
This completed clinical trial evaluated how a one-week exercise or mindfulness intervention affected social media use and well-being in coll…
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CLINICAL_TRIALS trial_result · 2025-05-31Clinical Trial Update: Efficacy and Safety of Toluedesvenlafaxine Hydrochloride Extended-release Tablets in Somatic Symptoms of Depression [Phase 4]
Phase 4 trial evaluating the efficacy and safety of toludesvenlafaxine hydrochloride extended-release tablets in somatic symptoms of depress…
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CLINICAL_TRIALS trial_result · 2025-05-31Clinical Trial Update: Mindfulness-based Stress Reduction Effects on Depression, Anxiety and Internalized Stigma Compared With Treatment-As-Usual Among Head and Neck Cancer Patients [NA]
A completed clinical trial compares mindfulness-based stress reduction with treatment-as-usual to assess effects on depression, anxiety, and…
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CLINICAL_TRIALS research · 2025-05-31Clinical Trial Update: EMDR 2.0 Group Therapy for PTSD, Depression, and Anxiety in Earthquake Survivors [NA]
A completed clinical trial evaluating EMDR 2.0 group therapy for PTSD, depression, and anxiety in earthquake survivors.
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CLINICAL_TRIALS research · 2025-05-31Clinical Trial Update: Implementation of Project YES in Ambulatory Adolescent & Young Adult Medicine [NA]
Clinical trial update for Project YES in ambulatory adolescent and young adult medicine. Enrollment by invitation is ongoing for conditions …
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CLINICAL_TRIALS research · 2025-05-31Clinical Trial Update: Income Volatility and Mental Health, Full Experiment [NA]
Cornell University is conducting a recruiting clinical trial to study how income volatility relates to depression and anxiety, with enrollme…
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CLINICAL_TRIALS research · 2025-05-31Clinical Trial Update: Establishing Mobile Transcranial Magnetic Stimulation [Phase 4]
Update on an ongoing Phase 4 trial evaluating mobile transcranial magnetic stimulation for treatment-resistant major depression, currently r…
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CLINICAL_TRIALS trial_result · 2025-05-30Clinical Trial Update: Multisite RCT of STEP-Home: A Transdiagnostic Skill-based Community Reintegration Workshop [NA]
A multisite randomized controlled trial evaluating STEP-Home, a transdiagnostic skill-based community reintegration workshop for individuals…
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CLINICAL_TRIALS trial_result · 2025-05-30Clinical Trial Update: Supervised Treadmill Intervention to Reduce Inflammation and Depression Through Exercise in HIV: The STRIDE Pilot Study [NA]
A completed pilot trial (STRIDE) evaluated a supervised treadmill exercise program to reduce inflammation and depressive symptoms in people …
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CLINICAL_TRIALS research · 2025-05-30Clinical Trial Update: Evaluating tDCS Brain-stimulation in Depression Using MRI [NA]
A UCLA-led clinical trial is evaluating transcranial direct current stimulation (tDCS) for major depressive disorder with MRI integration; r…