Major Depressive Disorder
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: Development and Multicenter Validation of an AI-Based Remote Photoplethysmography (rPPG) Facial Scan for Multimodal Health Assessment
This trial update covers the development and multicenter validation of an AI-based remote photoplethysmography (rPPG) facial scan for multim…
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CLINICAL_TRIALS trial_result · 2026-04-20Clinical Trial Update: HIV Engagement and Adolescent Depression Support (HEADS-UP) [NA]
A completed UNC-led clinical trial evaluating HIV engagement and support for adolescents with depression and anxiety.
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: Improving Brain Stimulation Through Imaging
Clinical trial update describing research on improving brain stimulation through imaging for depression. The study includes treatment-resist…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: Evaluation of a Keto-Like Supplement on Brain Responses to Emotional Stimuli in Depression [Phase 2]
A Phase 2 clinical trial is evaluating a keto-like dietary supplement on brain responses to emotional stimuli in people with depression. The…
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CLINICAL_TRIALS trial_result · 2026-04-20Clinical Trial Update: Pharmacokinetics, Safety, Tolerability and Efficacy of a Subcutaneous Long-Acting Injection of Cariprazine (Cariprazine Depot) in Subjects Eligible for Treatment With Oral Cariprazine [Phase 1, Phase 2]
The update covers a subcutaneous long-acting cariprazine depot studied in Phase 1/2 for pharmacokinetics, safety, tolerability, and efficacy…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: Promoting Mental Health of Teachers and Caregiver Using a Personalized mHealth Toolkit in Uganda [NA]
A trial update shows recruitment is ongoing for a study in Uganda to promote mental health among teachers and caregivers using a personalize…
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CLINICAL_TRIALS trial_result · 2026-04-20Clinical Trial Update: Therapeutic Touch and Acupressure on Depressive Symptoms [NA]
Completed clinical trial evaluating therapeutic touch and acupressure for depressive symptoms; the update does not provide efficacy or safet…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: Cognitive Training as an Adjunct to Ketamine in Real-world Clinics [NA]
A clinical trial is evaluating cognitive training as an adjunct to ketamine for depression in real-world clinics; the study is currently enr…
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CLINICAL_TRIALS trial_result · 2026-04-20Clinical Trial Update: Mobile Mental Health Stigma Reduction Intervention Among Black Adults [NA]
This entry reports the status of a clinical trial evaluating a mobile intervention aimed at reducing mental health stigma among Black adults…
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CLINICAL_TRIALS trial_result · 2026-04-20Clinical Trial Update: A Phase I/II Study of PDC-1421 for Treating Depression in Cancer Patients [Phase 1, Phase 2]
A Phase I/II clinical trial evaluating PDC-1421 for major depressive disorder in cancer patients; recruitment status is not yet recruiting.
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: Tracking Brain Biomarkers and Renormalization Associated With Antidepressant Transcranial Magnetic Stimulation Therapy
Clinical trial update on tracking brain biomarkers and renormalization associated with antidepressant transcranial magnetic stimulation ther…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: Implementing Action-Based Cognitive Remediation for Transdiagnostic Cognitive Difficulties in a Tertiary Mental Health Hospital [NA]
This clinical trial update describes a study at The Royal Ottawa Mental Health Centre testing action-based cognitive remediation for transdi…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: Enhancing Health in Rural Populations: Music as Therapy [NA]
Northern Arizona University is conducting a clinical trial to evaluate music therapy for stress, generalized anxiety, chronic pain, and depr…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: Natural History of Depression, Bipolar Disorder and Suicide Risk
This document describes an ongoing NIMH-sponsored clinical research study characterizing the natural history of depression, bipolar disorder…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: A Primary Care-Based Psychosocial Intervention To Improve Cognitive & Depression Outcomes in Older Adults With MCI & Early Stage AD [NA]
This clinical trial, sponsored by Weill Medical College of Cornell University, is recruiting to test a primary care-based psychosocial inter…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: Efficacy and Safety of Sertraline Combined With Lactobacillus Crispatus in Adolescents With Depression : A Multicenter Randomized Controlled Trial [Phase 2]
Phase 2 multicenter randomized trial assessing sertraline plus Lactobacillus crispatus probiotic for adolescents with major depressive disor…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: Sleep Mechanisms Of Regulating Emotions [NA]
A Stanford University study is recruiting to investigate how sleep mechanisms influence emotion regulation. Participants have insomnia or de…
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CLINICAL_TRIALS research · 2026-04-20Clinical Trial Update: Precarity and Reduction of Its Impact on the Mental Health of Health Students [NA]
A France-based clinical trial investigates how precarity affects mental health, including depression and quality of life, among health scien…
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CLINICAL_TRIALS trial_result · 2026-04-20Clinical Trial Update: Dyadic Interactions in Depressed and Non-Depressed Mothers and Their Infants
A completed NICHD clinical trial examined mother-infant dyadic interactions in the context of maternal depression.
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CLINICAL_TRIALS trial_result · 2026-04-17Clinical Trial Update: PD, PK, and Safety of ALTO-203 in Patients With MDD [Phase 2]
Phase 2 study evaluating pharmacodynamics, pharmacokinetics, and safety of ALTO-203 in patients with Major Depressive Disorder has completed…
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CLINICAL_TRIALS trial_result · 2026-04-17Clinical Trial Update: A Multiple Case Study of Schema Therapy for Difficult-to-treat Depression- DEPRE-ST*Case [NA]
A completed clinical trial using a multiple case study design to examine schema therapy for difficult-to-treat depression. The study status …
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CLINICAL_TRIALS trial_result · 2026-04-17Clinical Trial Update: Effectiveness of Behavioral Activation Group Therapy for Patients With Depression at the Community in Thanh Hoa [NA]
Clinical trial update indicating completion of a study assessing the effectiveness of Behavioral Activation Group Therapy for patients with …
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: Clinical Validation of Samsung Smartwatch
A clinical trial validating the Samsung smartwatch for assessment/monitoring of mental health conditions, focusing on major depressive disor…
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: Symptoms of Anxiety and/or Depression and SDM in Older Patients With CLTI
Clinical trial NCT07529886 from Guy's and St Thomas' NHS Foundation Trust investigates symptoms of anxiety and depression and shared decisio…
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CLINICAL_TRIALS research · 2026-04-17Clinical Trial Update: Sleep to Reduce Incident Depression Effectively in Peripartum [Phase 2]
A Phase 2 clinical trial sponsored by Henry Ford Health System is evaluating whether sleep interventions can reduce the onset of depression …