Major Depressive Disorder
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2025-09-30Clinical Trial Update: A Study to Assess Adverse Events of Fosigotifator (ABBV-CLS-7262) in Adults With Major Depressive Disorder [Phase 1]
Phase 1 clinical trial evaluating adverse events of Fosigotifator (ABBV-CLS-7262) in adults with major depressive disorder has been terminat…
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CLINICAL_TRIALS trial_result · 2025-09-30Clinical Trial Update: Evolution of Dark Ideas When Introducing or Switching an Antidepressant [NA]
A terminated clinical trial at University Hospital, Montpellier, studied how ideas evolve when introducing or switching antidepressants in a…
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CLINICAL_TRIALS research · 2025-09-30Clinical Trial Update: Effect of Virtual Reality and Trans Auricular X-Vagus Nerve Stimulation for Anxiety and Depression in Chronic Shoulder Pain Patients [NA]
Clinical trial update evaluating the combination of virtual reality and trans auricular X-Vagus nerve stimulation to address anxiety and dep…
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CLINICAL_TRIALS trial_result · 2025-09-30Clinical Trial Update: The Effect of Mandala Coloring on Depression, Anxiety and Quality of Life of Inpatients in a Psychiatric Clinic [NA]
A completed clinical trial assessing whether mandala coloring affects depression, anxiety, and quality of life in psychiatric inpatients.
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CLINICAL_TRIALS research · 2025-09-30Clinical Trial Update: Multimodal Differences in Effort-based Decision-Making in Depression [NA]
A clinical trial update describing a multimodal study of effort-based decision-making in individuals with depression and anhedonia; the stud…
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CLINICAL_TRIALS trial_result · 2025-09-30Clinical Trial Update: Self-Identification Program [NA]
A clinical trial sponsored by University Hospital, Montpellier is recruiting for a study on Major Depressive Disorder that uses Third Wave C…
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CLINICAL_TRIALS research · 2025-09-30Clinical Trial Update: Sleep Disturbances and Their Association With Serum Magnesium Level in Patients With Major Depressive Disorder
A clinical trial update from Assiut University examining the relationship between serum magnesium levels and sleep disturbances in patients …
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CLINICAL_TRIALS research · 2025-09-29Clinical Trial Update: IMPACT-D+: Immune-Modulating and Psychometric Effects of Accelerated TMS in Depression Plus Comorbid Post-COVID-19 Condition [NA]
This clinical trial evaluates accelerated transcranial magnetic stimulation for depression with comorbid post-COVID-19 condition, focusing o…
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CLINICAL_TRIALS trial_result · 2025-09-29Clinical Trial Update: Magnetic Randomized Trial in Elderly Depressed [NA]
A randomized magnetic therapy trial in elderly adults with Major Depressive Disorder has completed.
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FDA approval · 2025-09-29FDA Approved: DESIPRAMINE HYDROCHLORIDE — Supplemental Application (Alembic Pharmaceuticals Limited)
FDA approved a supplemental application for desipramine hydrochloride from Alembic Pharmaceuticals Limited.
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CLINICAL_TRIALS research · 2025-09-29Clinical Trial Update: Transdiagnostic, Indicated Preventive Intervention for Adolescents At High Risk of Emotional Problems W/Add-On Modules [NA]
A clinical trial update announcing a transdiagnostic preventive intervention for adolescents at high risk of emotional problems, with add-on…
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CLINICAL_TRIALS withdrawal · 2025-09-29Clinical Trial Update: Rapid Acting TMS for Suicide Ideation in Depression [NA]
The clinical trial NCT05100004 evaluating rapid-acting transcranial magnetic stimulation for suicide ideation in major depressive disorder h…
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CLINICAL_TRIALS research · 2025-09-29Clinical Trial Update: Targeting Specific Brain Networks to Treat Specific Symptoms in Depression [NA]
A Massachusetts General Hospital study is actively recruiting to test whether targeting specific brain networks can alleviate particular sym…
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FDA approval · 2025-09-26FDA Approved: FLUOXETINE — Supplemental Application (NIVAGEN PHARMACEUTICALS, INC.)
FDA approves a supplemental application for fluoxetine hydrochloride from NIVAGEN Pharmaceuticals, enabling the marketing of a generic fluox…
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CLINICAL_TRIALS trial_result · 2025-09-26Clinical Trial Update: Internet-based Psychotherapy for Depressed Elderly [NA]
A completed clinical trial evaluating internet-based psychotherapy for elderly individuals with depression.
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CLINICAL_TRIALS trial_result · 2025-09-26Clinical Trial Update: Effects of Altitude-like Cognition Training on Neuroplasticity and Cognitive Functions [NA]
A completed clinical trial evaluating altitude-like cognition training for improving neuroplasticity and cognitive function in people with c…
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CLINICAL_TRIALS research · 2025-09-26Clinical Trial Update: The Effect of a Six Week Intensified Pharmacological Treatment for Major Depressive Disorder Compared to Treatment as Usual in Subjects Who Had a First-time Treatment Failure on Their First-line Treatment. [Phase 3]
A Phase 3 clinical trial is examining whether a six-week intensified pharmacological treatment improves outcomes in adults with major depres…
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CLINICAL_TRIALS research · 2025-09-25Clinical Trial Update: Orexin Antagonism for Suicide Risk: A Proof-of-Concept Clinical Trial [Phase 2]
Phase 2 proof-of-concept trial testing orexin antagonism for suicide risk in major depressive disorder; currently recruiting.
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CLINICAL_TRIALS trial_result · 2025-09-25Clinical Trial Update: Relative Impacts on Preventative Primary Care--a Longitudinal Evaluation of COVID-19:Phase 1
Phase 1 longitudinal clinical trial update from McMaster University evaluating the relative impacts of COVID-19 on preventative primary care…
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CLINICAL_TRIALS withdrawal · 2025-09-25Clinical Trial Update: Investigating the Protective Impact of LY-2940094 on Stress-induced Depression- and Anxiety-related Phenotypes in Humans [Phase 2]
Phase 2 trial evaluating LY-2940094 for protection against stress-induced depression and anxiety phenotypes has been withdrawn before comple…
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CLINICAL_TRIALS trial_result · 2025-09-25Clinical Trial Update: Using Financial Incentives and Screening to Increase Engagement With Mental Health Services Among College Students in Chennai, India [NA]
Clinical trial in Chennai, India tested whether financial incentives and systematic screening can increase college students' engagement with…
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CLINICAL_TRIALS research · 2025-09-25Clinical Trial Update: Prediction of Antidepressant Effects of Electroconvulsive Therapy
A clinical trial is investigating whether electroconvulsive therapy can predict antidepressant effects in patients with major depressive dis…
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CLINICAL_TRIALS research · 2025-09-25Clinical Trial Update: Invasive Decoding and Stimulation of Altered Reward Computations in Depression Patients [NA]
A clinical trial investigating invasive decoding and stimulation to modify reward processing in patients with Major Depressive Disorder, cur…
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CLINICAL_TRIALS trial_result · 2025-09-24Clinical Trial Update: A Study of CLE-100 (Oral Esketamine) in Addition to Standard Antidepressant Drug for Major Depressive Disorder - CLEO Study [Phase 2]
A Phase 2 study evaluating CLE-100, an oral esketamine, as an adjunct to a standard antidepressant for adults with major depressive disorder…
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CLINICAL_TRIALS trial_result · 2025-09-24Clinical Trial Update: Mobile Health and COVID-19 [NA]
The University of Houston reports the completion of a mobile health clinical trial related to COVID-19 and its impact on anxiety and depress…