Major Depressive Disorder
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2025-12-01Clinical Trial Update: NBI-1065845-MDD3025: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD) [Phase 3]
Phase 3 clinical trial evaluating NBI-1065845 as an adjunctive treatment for major depressive disorder; currently recruiting.
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CLINICAL_TRIALS research · 2025-12-01Clinical Trial Update: Intermittent Theta Burst Stimulation for Maintenance Therapy in Depression [NA]
A clinical trial is evaluating intermittent theta burst stimulation as maintenance therapy for depression and is currently recruiting.
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CLINICAL_TRIALS research · 2025-12-01Clinical Trial Update: Theta Burst Stimulation in Pharmacologically Untreated Patients as Sole Antidepressant Treatment [NA]
A clinical trial update describes theta burst stimulation used as the sole antidepressant treatment in patients who have not received pharma…
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CLINICAL_TRIALS research · 2025-12-01Clinical Trial Update: Pilot Study of Brief Culturally Adapted Behavioral Activation for Adults With Depression in Primary Care Setting [NA]
A pilot study evaluating a Brief Culturally Adapted Behavioral Activation intervention for adults with depression in primary care is current…
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CLINICAL_TRIALS research · 2025-12-01Clinical Trial Update: Effectiveness of a Guided Self-Help CBT Manual 'KOK' in Cancer Patients [NA]
This clinical trial registry entry describes an upcoming study to evaluate the effectiveness of a guided self-help CBT manual 'KOK' in patie…
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CLINICAL_TRIALS trial_result · 2025-11-28Clinical Trial Update: Ketamine Versus Midazolam for Recurrence of Suicidality in Adolescents [Phase 3]
Phase 3 trial comparing ketamine to midazolam for recurrence of suicidality in adolescents has completed.
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CLINICAL_TRIALS trial_result · 2025-11-28Clinical Trial Update: Efficacy and Safety Study of Levomilnacipran Hydrochloride Extended-Release Capsules in Major Depressive Disorder [Phase 3]
This update notes the completion of a Phase 3 efficacy and safety study evaluating levomilnacipran ER for major depressive disorder.
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CLINICAL_TRIALS trial_result · 2025-11-28Clinical Trial Update: Fitness for Brain Optimization for Late-Life Depression [NA]
This clinical trial update notes the completion of a study evaluating fitness for brain optimization to treat depression in older adults.
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CLINICAL_TRIALS research · 2025-11-28Clinical Trial Update: Combination of Novel Therapies for CKD Comorbid Depression [Phase 2]
Phase 2 clinical trial evaluating a combination of novel therapies for chronic kidney disease with comorbid depression is currently recruiti…
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CLINICAL_TRIALS research · 2025-11-28Clinical Trial Update: Impact of Therapeutic Exercise Integrated With Psychotherapy and Education in Patients With Depression [NA]
This clinical trial update describes a planned study evaluating the combined effects of therapeutic exercise, psychotherapy, and education f…
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CLINICAL_TRIALS research · 2025-11-28Clinical Trial Update: Heart Rate Variability (HRV)-Guided Transcranial Direct Current Stimulation (tDCS) [NA]
A clinical trial from NYU Langone Health is investigating heart rate variability-guided transcranial direct current stimulation for depressi…
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CLINICAL_TRIALS research · 2025-11-28Clinical Trial Update: DBS of the Lateral Habenula in Treatment-Resistant Depression [NA]
This document notes an ongoing clinical trial evaluating deep brain stimulation of the lateral habenula for treatment-resistant major depres…
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CLINICAL_TRIALS research · 2025-11-28Clinical Trial Update: An Open-Label Study to Evaluate the Safety, Tolerability and Pharmacodynamics of BPL-003 in Patients With Treatment Resistant Depression [Phase 2]
Open-label Phase 2 study to evaluate the safety, tolerability, and pharmacodynamics of BPL-003 in patients with treatment-resistant depressi…
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CLINICAL_TRIALS research · 2025-11-28Clinical Trial Update: Long-term Observation of Participants With Mood Disorders
An ongoing long-term observational study led by the National Institute of Mental Health is recruiting participants with mood disorders. The …
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CLINICAL_TRIALS research · 2025-11-28Clinical Trial Update: Supportive-Expressive and Emotion-Focused Treatment for Depression [NA]
This clinical trial from the University of Haifa is evaluating supportive-expressive and emotion-focused treatment for major depressive diso…
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CLINICAL_TRIALS trial_result · 2025-11-26Clinical Trial Update: Study to Evaluate the Effects of Oral NMRA-335140 Versus Placebo in Participants With Major Depressive Disorder [Phase 3]
A Phase 3 clinical trial evaluating oral NMRA-335140 versus placebo in adults with major depressive disorder has completed, per the Clinical…
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CLINICAL_TRIALS trial_result · 2025-11-26Clinical Trial Update: POST Facilitation for Community Dwelling Older Adults (POST-RCT) [NA]
Clinical trial POST-RCT evaluating facilitation for community-dwelling older adults has completed. The study tracked anxiety, depression, an…
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CLINICAL_TRIALS research · 2025-11-26Clinical Trial Update: Transparent Communication to Improve Mental Wellbeing and Attitude Towards Reintegration [NA]
Clinical trial update on transparent communication to improve mental wellbeing and attitude toward reintegration; the study focuses on Depre…
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CLINICAL_TRIALS research · 2025-11-26Clinical Trial Update: Preventing Anxiety and Depression in Older Hispanics [NA]
Clinical trial update describes a University of Miami study aiming to prevent anxiety and depression in older Hispanics; the trial is curren…
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CLINICAL_TRIALS research · 2025-11-26Clinical Trial Update: The Health and Social Consequences of Depression Among the Elderly [NA]
A recruiting clinical study investigates the health and social consequences of depression among older adults, sponsored by the National Bure…
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CLINICAL_TRIALS research · 2025-11-26Clinical Trial Update: Antidepressant Adherence for Depressed Adults in Primary Care [NA]
A University of Pennsylvania–sponsored study on antidepressant adherence in adults with depression in primary care, currently recruiting.
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CLINICAL_TRIALS research · 2025-11-26Clinical Trial Update: Psilocybin rTMS for Treatment Resistant Depression [Phase 2]
A Phase 2 clinical trial at the University of Texas at Austin is testing psilocybin-assisted rTMS for treatment-resistant depression and is …
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CLINICAL_TRIALS research · 2025-11-25Clinical Trial Update: Multimodal Phenotyping in Adolescent Inpatient Depression: An Observational Study
This observational study aims to explore multimodal phenotyping in adolescents hospitalized with depression and is currently recruiting.
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CLINICAL_TRIALS research · 2025-11-25Clinical Trial Update: Dapagliflozin in Depression [Phase 1, Phase 2]
A clinical trial is evaluating dapagliflozin for depression in Phase 1 and Phase 2; recruitment is ongoing at Tanta University.
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CLINICAL_TRIALS trial_result · 2025-11-25Clinical Trial Update: Telepsychology in Spinal Cord Injury [NA]
A completed clinical trial evaluated telepsychology for individuals with spinal cord injury and depression.