Major Depressive Disorder
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2025-12-16Clinical Trial Update: Sequential Multiple Assignment Randomized Trial for Bipolar Depression [Phase 4]
This ClinicalTrials.gov Phase 4 study uses a sequential multiple assignment randomized trial design to evaluate treatments for bipolar depre…
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CLINICAL_TRIALS research · 2025-12-16Clinical Trial Update: Effectiveness of Digital Cognitive Behavioral Therapy for the Treatment of Depression [NA]
This entry notes an ongoing clinical trial evaluating digital cognitive behavioral therapy for depression, with status listed as active but …
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CLINICAL_TRIALS research · 2025-12-16Clinical Trial Update: Implementation Strategies for Task-Shifting Depression Care Depression Care in Vietnam [NA]
Completed clinical trial updating on implementation strategies for task-shifting depression care in Vietnam. The study focuses on care deliv…
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CLINICAL_TRIALS trial_result · 2025-12-15Clinical Trial Update: ABSORB (Amount of Blueberries So Older Adults Reap Benefits) [NA]
A completed clinical trial evaluating whether blueberry consumption benefits depressive symptoms in older adults; results have been posted.
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CLINICAL_TRIALS research · 2025-12-15Clinical Trial Update: Comparative Effectiveness of ECT vs. KETAMINE Over the Lifespan [Phase 4]
Ongoing Phase 4 trial comparing electroconvulsive therapy (ECT) and ketamine for acute suicidal depression, evaluating comparative effective…
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CLINICAL_TRIALS research · 2025-12-15Clinical Trial Update: Predictors of rTMS and Group Therapy Efficacy in Adolescent Depression
This completed clinical trial investigates predictors of response to rTMS and group therapy in adolescents with major depressive disorder.
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CLINICAL_TRIALS research · 2025-12-15Clinical Trial Update: Investigation on Risk Factors for Suicide Among Chinese Patients With Mood Disorders
A Shanghai Mental Health Center study is investigating risk factors for suicide among Chinese patients with mood disorders (bipolar disorder…
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CLINICAL_TRIALS research · 2025-12-15Clinical Trial Update: Effectiveness of Digital Cognitive Behavioral Therapy for the Treatment of Depression: a Real-world Study [NA]
A real-world study is evaluating the effectiveness of digital cognitive behavioral therapy for depression. The trial is currently recruiting…
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CLINICAL_TRIALS research · 2025-12-15Clinical Trial Update: Implementation of Collaborative Care for Depression in VA HIV Clinics [NA]
Trial update on implementing collaborative care for depression in VA HIV clinics; the study is active but not recruiting.
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CLINICAL_TRIALS trial_result · 2025-12-15Clinical Trial Update: Cognitive Behavioral Immersion: A Randomized Control Trial of Peer-Based Coaching in the Metaverse [NA]
A completed randomized trial assessing a peer-based coaching intervention delivered in a metaverse setting for depression and anxiety.
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CLINICAL_TRIALS research · 2025-12-15Clinical Trial Update: Video Intervention to Reduce Depression-related Stigma Among Adolescents [NA]
A clinical trial evaluating a video intervention designed to reduce depression-related stigma among adolescents; the study is currently not …
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CLINICAL_TRIALS trial_result · 2025-12-12Clinical Trial Update: Pramipexole to Target "Anhedonic Depression" [Phase 2]
Phase 2 trial of pramipexole for anhedonic depression has been completed, evaluating its effects in bipolar and unipolar depression. Results…
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CLINICAL_TRIALS trial_result · 2025-12-12Clinical Trial Update: Psilocybin-assisted CBT for Depression [Phase 1]
Phase 1 study evaluating psilocybin-assisted cognitive-behavioral therapy for Major Depressive Disorder has been completed.
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CLINICAL_TRIALS research · 2025-12-12Clinical Trial Update: Treatment of SSD With tcVNS and taVNS [NA]
A clinical trial is evaluating transcutaneous vagus nerve stimulation (tcVNS) and taVNS for somatic symptom disorder with anxiety and depres…
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CLINICAL_TRIALS research · 2025-12-12Clinical Trial Update: Validate the Temporal Stability and Responsiveness of AI-COA® for Depression and Anxiety
Clinical trial update to validate the temporal stability and responsiveness of AI-COA for depression and anxiety; not yet recruiting.
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CLINICAL_TRIALS research · 2025-12-12Clinical Trial Update: Prediction of REsponse to Depression Interventions Using Clinical and TD-fNIRS Measurements
Kernel is conducting a clinical study to predict response to depression interventions using clinical data and TD-fNIRS measurements. The stu…
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CLINICAL_TRIALS research · 2025-12-12Clinical Trial Update: Integrated Care for Older Adults With Major Depression and Physical Multimorbidity - The I-CONNECT [NA]
This clinical trial is currently recruiting to test an integrated care model for older adults (65 years and older) with major depressive dis…
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CLINICAL_TRIALS research · 2025-12-12Clinical Trial Update: Comparing Inflammatory Markers in Patients With and Without Depression With Chronic Periodontitis [NA]
This clinical trial update describes a study comparing inflammatory markers in patients with chronic periodontitis who have depression versu…
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CLINICAL_TRIALS research · 2025-12-12Clinical Trial Update: Early Life Stress and Depression: Molecular and Functional Imaging
A study sponsored by McLean Hospital on early life stress and depression using molecular and functional imaging, currently recruiting partic…
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CLINICAL_TRIALS research · 2025-12-12Clinical Trial Update: Culturally Adapted i-CBT for Farsi/Dari Speaking Migrants [NA]
A Karolinska Institutet–sponsored trial is recruiting to evaluate a culturally adapted internet-based cognitive-behavioral therapy for Farsi…
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CLINICAL_TRIALS research · 2025-12-12Clinical Trial Update: Cross-over Study on the Influence of Fampridine on Working Memory in Mild to Moderate Depression [Phase 2]
This Phase 2 cross-over trial investigates whether dalfampridine affects working memory in people with mild to moderate depression and is cu…
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CLINICAL_TRIALS research · 2025-12-12Clinical Trial Update: Chronic Pain in the General Population of Chile
This is a completed clinical trial in Chile examining chronic pain and related conditions, including migraine disability and several comorbi…
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CLINICAL_TRIALS research · 2025-12-12Clinical Trial Update: Long-Term Maintenance With Ketamine and Esketamine for Reduction of Suicide in High-Risk Patients With Depression [Phase 4]
This Phase 4 clinical trial is evaluating long-term maintenance with ketamine and esketamine to reduce suicide risk in adults with Major Dep…
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CLINICAL_TRIALS trial_result · 2025-12-12Clinical Trial Update: Comparison of Propofol and Ketofol as Induction Agents for Electroconvulsive Therapy [NA]
A completed clinical trial comparing propofol and ketofol as induction agents for electroconvulsive therapy in adults with major depressive …
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CLINICAL_TRIALS research · 2025-12-12Clinical Trial Update: Pharmaco-Neuroimaging Studies of Approach/Avoidance Behaviors and Post-Mortem Studies: Study 1.2 (Stress Manipulation)
This update concerns Study 1.2 on pharmaco-neuroimaging of approach/avoidance behaviors with stress manipulation in people with major depres…