Major Depressive Disorder
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS trial_result · 2026-01-15Clinical Trial Update: Improving Adherence to Homework During Therapy [NA]
A completed University of South Florida trial evaluated strategies to improve adherence to homework during therapy for anxiety and depressio…
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CLINICAL_TRIALS research · 2026-01-15Clinical Trial Update: Latino Teen Depression Treatment Study
A Duke University-led clinical trial studying treatments for depression in Latino teenagers is currently recruiting participants.
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FDA approval · 2026-01-14FDA Approved: OLANZAPINE AND FLUOXETINE — Supplemental Application (Teva Pharmaceuticals USA, Inc.)
FDA approved Teva's supplemental application for a fixed-dose combination of olanzapine and fluoxetine, adding its use for depressive episod…
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CLINICAL_TRIALS trial_result · 2026-01-14Clinical Trial Update: Clinical Trials to Evaluate Metformin to Treat Depression in People Living With HIV [Phase 2]
A Phase 2 clinical trial is evaluating metformin as a treatment for depression in people living with HIV. The study is not yet recruiting.
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CLINICAL_TRIALS trial_result · 2026-01-14Clinical Trial Update: Role Of Non-Specific Effects in The Treatment of Depression With Esketamine [NA]
A Yale-led trial evaluating non-specific effects in the treatment of depressive episodes with esketamine was terminated; results were posted…
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CLINICAL_TRIALS research · 2026-01-14Clinical Trial Update: Meditative Neurofeedback for Depression [NA]
This ClinicalTrials.gov entry documents a recruiting study evaluating meditative neurofeedback as a potential treatment for major depressive…
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CLINICAL_TRIALS research · 2026-01-14Clinical Trial Update: The Effect of Digital Markers in the Self-management of Depressive Symptoms [NA]
This clinical trial update reports on an enrolling-by-invitation study investigating how digital markers can aid self-management of depressi…
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CLINICAL_TRIALS research · 2026-01-14Clinical Trial Update: Adolescent Mood During Puberty and Testosterone [NA]
A clinical trial is recruiting to study how puberty and testosterone influence mood in adolescents with depression. The study is sponsored b…
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CLINICAL_TRIALS research · 2026-01-14Clinical Trial Update: Dosing rTMS for Depression Post-SCI [NA]
This clinical trial update reports ongoing recruitment for dosing parameters of repetitive transcranial magnetic stimulation (rTMS) to treat…
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FDA approval · 2026-01-13FDA Approved: OLANZAPINE AND FLUOXETINE — Supplemental Application (Par Health USA, LLC)
FDA approved a supplemental application for the generic combination of olanzapine and fluoxetine, manufactured by Par Health USA, LLC.
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CLINICAL_TRIALS research · 2026-01-13Clinical Trial Update: Effects of a Classic High-frequency rTMS Treatment Versus a Deep rTMS Treatment [NA]
A clinical trial compares classic high-frequency rTMS with deep rTMS for treatment-resistant depression and is currently recruiting.
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CLINICAL_TRIALS trial_result · 2026-01-13Clinical Trial Update: Testing the Effectiveness of Cognitive Training Among Depressed Patients Receiving Esketamine Treatment [NA]
A clinical trial evaluating cognitive training for patients with major depressive disorder receiving esketamine has been suspended, per the …
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CLINICAL_TRIALS research · 2026-01-13Clinical Trial Update: University of North Carolina Alumni Heart Study
Clinical trial update on the University of North Carolina Alumni Heart Study, sponsored by Duke University, shows the study is active but no…
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CLINICAL_TRIALS trial_result · 2026-01-13Clinical Trial Update: Mindfulness-based Cognitive Therapy for the Chronic Pain-depression Co-morbidity Among Older Black Adults in the Community; The Quiet Focus Open Pilot [NA]
This completed open-pilot trial evaluated mindfulness-based cognitive therapy for the co-occurrence of chronic pain and depression among old…
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CLINICAL_TRIALS research · 2026-01-13Clinical Trial Update: Clinical Trial to Investigate the Safety and Efficacy of Two Dexamfetamine Sulfate Formulations in Adults With ADHD and Moderate to Severe Depression [Phase 2]
Phase 2 clinical trial update evaluating two dexamfetamine sulfate formulations for safety and efficacy in adults with ADHD and major depres…
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CLINICAL_TRIALS research · 2026-01-12Clinical Trial Update: First-In-Human (FIH), Single Ascending Dose (SAD) Study and Multiple Ascending Dose (MAD) Study of SP-101 Injection [Phase 1]
This is a first-in-human Phase 1 study evaluating single ascending dose and multiple ascending dose cohorts of SP-101 injection in adults wi…
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CLINICAL_TRIALS trial_result · 2026-01-12Clinical Trial Update: Intervention Effect of High Definition Transcranial Direct Current Stimulation (HD-tDCS) on Depressive Disorder [NA]
A completed clinical trial examined the effect of high-definition transcranial direct current stimulation (HD-tDCS) on depressive disorder, …
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CLINICAL_TRIALS trial_result · 2026-01-12Clinical Trial Update: Effectiveness of Exercise, Walking, and Education on Mental Health, Mobility and Quality of Life in Elderly Residents of Nursing Homes [NA]
This completed clinical trial evaluated whether a program combining exercise, walking, and education improves mental health, mobility, and q…
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CLINICAL_TRIALS research · 2026-01-12Clinical Trial Update: Behavioral Activation for Depression and Habitual Rumination [NA]
A clinical trial update indicates a study evaluating Behavioral Activation for Depression and Habitual Rumination in individuals with major …
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CLINICAL_TRIALS withdrawal · 2026-01-12Clinical Trial Update: Low-Intensity Focused Ultrasound for Treatment-Resistant Depression [NA]
Trial evaluating low-intensity focused ultrasound for treatment-resistant depression has been suspended.
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CLINICAL_TRIALS trial_result · 2026-01-12Clinical Trial Update: Transcranial Magnetic Stimulation for Youth With Treatment-Resistant Major Depressive Disorder [Phase 2]
Phase 2 trial of transcranial magnetic stimulation for youths with treatment-resistant major depressive disorder has been suspended.
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CLINICAL_TRIALS research · 2026-01-12Clinical Trial Update: Training in Evidence-based Treatments in Psycho-Oncology [NA]
This ClinicalTrials.gov entry describes a Massachusetts General Hospital study focused on training in evidence-based treatments for psycho-o…
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CLINICAL_TRIALS research · 2026-01-12Clinical Trial Update: Antidepressant Effects of Nitrous Oxide [Phase 2]
Phase 2 clinical trial evaluating the antidepressant effects of nitrous oxide in major depressive disorder and treatment-resistant depressio…
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CLINICAL_TRIALS trial_result · 2026-01-12Clinical Trial Update: The Effect of Mindfulness-based Stress Reduction Programme Given to Infertile Women [NA]
A completed clinical trial evaluating a mindfulness-based stress reduction program for infertile women. The study examines effects on depres…
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CLINICAL_TRIALS research · 2026-01-12Clinical Trial Update: Investigating the Brain's Physiological Responses in Depression and Autism, Using Transcranial Magnetic Stimulation and Electroencephalography
A clinical trial from National Taiwan University Hospital is enrolling individuals with autism and major depressive disorder to study brain …