Major Depressive Disorder
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Sign up freeTop drugs studied for this disease
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CLINICAL_TRIALS research · 2026-03-20Clinical Trial Update: Zelquistinel or Placebo for the Reduction of Symptoms of Major Depressive Disorder [Phase 2]
Phase 2 clinical trial comparing Zelquistinel to placebo for reducing symptoms of Major Depressive Disorder; recruitment is ongoing.
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CLINICAL_TRIALS research · 2026-03-20Clinical Trial Update: Clinical Assessment of Response in the Treatment of Depression With Daytime Sleepiness Using Solriamfetol [Phase 3]
A Phase 3 clinical trial is ongoing to assess the response to solriamfetol for treating major depressive disorder with excessive daytime sle…
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CLINICAL_TRIALS research · 2026-03-20Clinical Trial Update: Effect of Mindfulness-based Psychoeducation in Depression [NA]
A clinical trial is evaluating mindfulness-based psychoeducation, including mindfulness-based stress reduction, for adults with major depres…
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CLINICAL_TRIALS trial_result · 2026-03-19Clinical Trial Update: A Study of CLE-100 (Oral Esketamine) as an Adjunctive Treatment to Standard Antidepressants for Major Depressive Disorder [Phase 2]
Phase 2 study of CLE-100, an oral esketamine, as an adjunct to standard antidepressants for major depressive disorder, has completed its tri…
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CLINICAL_TRIALS research · 2026-03-19Clinical Trial Update: A Clinical Trial of Add-on Oral Slow-release Ketamine Treatment in Major Depression [Phase 2]
This clinical trial update describes an ongoing Phase 2 study evaluating add-on oral slow-release ketamine for major depressive disorder.
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CLINICAL_TRIALS research · 2026-03-19Clinical Trial Update: Neurocognitive Effects of FMT in MDD Patients With and Without IBS [Phase 2, Phase 3]
Clinical trial update on the neurocognitive effects of fecal microbiota transplant in patients with major depressive disorder, with and with…
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CLINICAL_TRIALS research · 2026-03-19Clinical Trial Update: rTMS for Depression in Young Adults With Autism [NA]
Clinical trial update indicating ongoing recruitment for a study assessing repetitive transcranial magnetic stimulation (rTMS) to treat depr…
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CLINICAL_TRIALS research · 2026-03-19Clinical Trial Update: Adjunctive Bright Light Therapy in Adolescents With Depression and Eveningness [NA]
A clinical trial is evaluating adjunctive bright light therapy for adolescents with unipolar depression and eveningness; the study is curren…
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CLINICAL_TRIALS research · 2026-03-19Clinical Trial Update: Get ActivE Study for At-risk Youth [NA]
The Get ActivE study at the University of Pittsburgh is recruiting at-risk youth with anhedonia and depression with suicidal ideation.
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CLINICAL_TRIALS research · 2026-03-19Clinical Trial Update: TCI-Massage Clinical Trial [NA]
The TCI-Massage clinical trial is listed as active but not recruiting, investigating effects on PTSD and comorbid conditions such as chronic…
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CLINICAL_TRIALS research · 2026-03-19Clinical Trial Update: A Study to Evaluate the Maintenance Effect of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD) [Phase 3]
This entry describes a Phase 3 clinical trial evaluating NBI-1065845 as an adjunctive maintenance therapy for adults with major depressive d…
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CLINICAL_TRIALS research · 2026-03-19Clinical Trial Update: Voice Analysis Technology to Detect and Manage Depression and Anxiety in Cardiac Rehabilitation [NA]
Mayo Clinic is conducting a study using voice analysis technology to detect and manage depression and anxiety among patients undergoing card…
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CLINICAL_TRIALS research · 2026-03-19Clinical Trial Update: Cerebellar Stimulation and Cognitive Control [NA]
A clinical trial update notes that a cerebellar stimulation study assessing cognitive control is currently recruiting, with conditions inclu…
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CLINICAL_TRIALS research · 2026-03-19Clinical Trial Update: A Randomized Controlled Trial of a VR Social Music-Movement Exergame for Depression and Anxiety in Young Adults [NA]
A randomized controlled trial protocol is described for a VR social music-movement exergame aimed at treating depression and anxiety in youn…
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CLINICAL_TRIALS research · 2026-03-18Clinical Trial Update: Moving on After Breast Cancer Trial for Depressed Breast Cancer Survivors in Pakistan [NA]
This document is a clinical trial update indicating a study evaluating interventions for major depressive disorder in breast cancer survivor…
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CLINICAL_TRIALS research · 2026-03-18Clinical Trial Update: Biomarker Research on Ultra-High-Field MRI Combined With Visual Perception Assessment in the Diagnosis and Treatment Outcomes of Severe Mental Disorders
This clinical trial update describes a study evaluating ultra-high-field MRI biomarkers combined with visual perception assessment to improv…
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CLINICAL_TRIALS research · 2026-03-18Clinical Trial Update: Efficacy and Mechanisms of Escitalopram in Drug-Naïve First-Episode Major Depressive Disorder [NA]
This clinical trial update reports on planned evaluation of escitalopram's efficacy and mechanisms in drug-naïve patients with a first episo…
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CLINICAL_TRIALS research · 2026-03-18Clinical Trial Update: Cost-effectiveness and Implementation of a Transdiagnostic Internet-based Intervention for Emotional Disorders in Community Care. [NA]
A clinical trial update describes the cost-effectiveness and implementation of a transdiagnostic internet-based intervention for emotional d…
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CLINICAL_TRIALS trial_result · 2026-03-18Clinical Trial Update: Optimizing tDCS Protocol for Clinical Use in Major Depressive Disorder [NA]
A completed clinical trial update on optimizing transcranial direct current stimulation (tDCS) protocol for major depressive disorder.
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CLINICAL_TRIALS trial_result · 2026-03-18Clinical Trial Update: Optimize and Predict Antidepressant Efficacy for Patient With MDD Using Multi-omics Analysis and AI-predictive Tool
An update on a clinical trial studying multi-omics and AI-based prediction to optimize antidepressant efficacy in major depressive disorder.…
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CLINICAL_TRIALS research · 2026-03-18Clinical Trial Update: TDM-Guided Treatment With SSRIs in Hospitalized Adults and Children [Phase 4]
Phase 4 trial evaluating TDM-guided treatment with selective serotonin reuptake inhibitors in hospitalized adults and children with major de…
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CLINICAL_TRIALS research · 2026-03-18Clinical Trial Update: Aromatherapy for Mental Health Promotion in IVF Patients [NA]
This notice reports an ongoing clinical trial at Federal University of Minas Gerais investigating aromatherapy to promote mental health in I…
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CLINICAL_TRIALS research · 2026-03-18Clinical Trial Update: Dopamine Modulation of Motivation and Motor Function in Major Depression & Inflammation [NA]
A Charité University-sponsored trial is evaluating dopamine modulation of motivation and motor function in adults with major depressive diso…
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CLINICAL_TRIALS research · 2026-03-18Clinical Trial Update: Spectral TMS (s-TMS) [NA]
Spectral TMS is being studied for Major Depressive Disorder in a UCLA-sponsored trial that is enrolling by invitation.
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CLINICAL_TRIALS trial_result · 2026-03-17Clinical Trial Update: Anhedonia, Development, and Emotions: Phenotyping and Therapeutics [Phase 4]
Phase 4 clinical trial update examining anhedonia, development, and emotions, including phenotyping and therapeutic approaches; results have…